3,183 research outputs found
A model for orientation effects in electronâtransfer reactions
A method for solving the singleâparticle Schrödinger equation with an oblate spheroidal potential of finite depth is presented. The wave functions are then used to calculate the matrix element T_BA which appears in theories of nonadiabatic electron transfer. The results illustrate the effects of mutual orientation and separation of the two centers on TBA. Trends in these results are discussed in terms of geometrical and nodal structure effects. Analytical expressions related to T_BA for states of spherical wells are presented and used to analyze the nodal structure effects for T_BA for the spheroidal wells
Magnetization reversal and local switching fields of ferromagnetic Co/Pd microtubes with radial magnetization
Three-dimensional nanomagnetism is a rapidly growing field of research covering both noncollinear spin textures and curved magnetic geometries including microtubular structures. We spatially resolve the field-induced magnetization reversal of free-standing ferromagnetic microtubes utilizing multifrequency magnetic force microscopy (MFM). The microtubes are composed of Co/Pd multilayer films with perpendicular magnetic anisotropy that translates to an anisotropy with radial easy axis upon rolling-up. Simultaneously mapping the topography and the perpendicular magnetostatic force derivative, the relation between surface angle and local magnetization configuration is evaluated for a large number of locations with slopes exceeding 45 degrees. The angle-dependence of the switching field is concurrent with the Kondorsky model, i.e., the rolled-up nanomembrane behaves like a planar magnetic film with perpendicular anisotropy and a pinning dominated magnetization reversal. Additionally, we discuss methodological challenges when detecting magnetostatic force derivatives near steep surfaces
Lack of the Sodium-Driven Chloride Bicarbonate Exchanger NCBE Impairs Visual Function in the Mouse Retina
Regulation of ion and pH homeostasis is essential for normal neuronal function. The sodium-driven chloride bicarbonate exchanger NCBE (Slc4a10), a member of the SLC4 family of bicarbonate transporters, uses the transmembrane gradient of sodium to drive cellular net uptake of bicarbonate and to extrude chloride, thereby modulating both intracellular pH (pHi) and chloride concentration ([Cl-]i) in neurons. Here we show that NCBE is strongly expressed in the retina. As GABAA receptors conduct both chloride and bicarbonate, we hypothesized that NCBE may be relevant for GABAergic transmission in the retina. Importantly, we found a differential expression of NCBE in bipolar cells: whereas NCBE was expressed on ON and OFF bipolar cell axon terminals, it only localized to dendrites of OFF bipolar cells. On these compartments, NCBE colocalized with the main neuronal chloride extruder KCC2, which renders GABA hyperpolarizing. NCBE was also expressed in starburst amacrine cells, but was absent from neurons known to depolarize in response to GABA, like horizontal cells. Mice lacking NCBE showed decreased visual acuity and contrast sensitivity in behavioral experiments and smaller b-wave amplitudes and longer latencies in electroretinograms. Ganglion cells from NCBE-deficient mice also showed altered temporal response properties. In summary, our data suggest that NCBE may serve to maintain intracellular chloride and bicarbonate concentration in retinal neurons. Consequently, lack of NCBE in the retina may result in changes in pHi regulation and chloride-dependent inhibition, leading to altered signal transmission and impaired visual function
'Designer atoms' for quantum metrology
Entanglement is recognized as a key resource for quantum computation and
quantum cryptography. For quantum metrology, the use of entangled states has
been discussed and demonstrated as a means of improving the signal-to-noise
ratio. In addition, entangled states have been used in experiments for
efficient quantum state detection and for the measurement of scattering
lengths. In quantum information processing, manipulation of individual quantum
bits allows for the tailored design of specific states that are insensitive to
the detrimental influences of an environment. Such 'decoherence-free subspaces'
protect quantum information and yield significantly enhanced coherence times.
Here we use a decoherence-free subspace with specifically designed entangled
states to demonstrate precision spectroscopy of a pair of trapped Ca+ ions; we
obtain the electric quadrupole moment, which is of use for frequency standard
applications. We find that entangled states are not only useful for enhancing
the signal-to-noise ratio in frequency measurements - a suitably designed pair
of atoms also allows clock measurements in the presence of strong technical
noise. Our technique makes explicit use of non-locality as an entanglement
property and provides an approach for 'designed' quantum metrology
Characterization of MCF mammary epithelial cells overexpressing the Arylhydrocarbon receptor (AhR)
<p>Abstract</p> <p>Background</p> <p>Recent reports indicate the existence of breast cancer cells expressing very high levels of the Arylhydrocarbon receptor (AhR), a ubiquitous intracellular receptor best known for mediating toxic action of dioxin and related pollutants. Positive correlation between the degree of AhR overexpression and states of increasing transformation of mammary epithelial cells appears to occur in the absence of any exogenous AhR ligands. These observations have raised many questions such as why and how AhR is overexpressed in breast cancer and its physiological roles in the progression to advanced carcinogenic transformation. To address those questions, we hypothesized that AhR overexpression occurs in cells experiencing deficiencies in normally required estrogen receptor (ER) signaling, and the basic role of AhR in such cases is to guide the affected cells to develop orchestrated cellular changes aimed at substituting the normal functions of ER. At the same time, the AhR serves as the mediator of the cell survival program in the absence of ER signaling.</p> <p>Methods</p> <p>We subjected two lines of Michigan Cancer Foundation (MCF) mammary epithelial cells to 3 different types ER interacting agents for a number of passages and followed the changes in the expression of AhR mRNA. The resulting sublines were analyzed for phenotypical changes and unique molecular characteristics.</p> <p>Results</p> <p>MCF10AT1 cells continuously exposed to 17-beta-estradiol (E2) developed sub-lines that show AhR overexpression with the characteristic phenotype of increased proliferation, and distinct resistance to apoptosis. When these chemically selected cell lines were treated with a specific AhR antagonist, 3-methoxy-4-nitroflavone (MNF), both of the above abnormal cellular characteristics disappeared, indicating the pivotal role of AhR in expressing those cellular phenotypes. The most prominent molecular characteristics of these AhR overexpressing MCF cells were found to be overexpression of ErbB2 and COX-2. Furthermore, we could demonstrate that suppression of AhR functions through anti-AhR siRNA or MNF causes the recovery of ERalpha functions.</p> <p>Conclusion</p> <p>One of the main causes for AhR overexpression in these MCF breast cancer cells appears to be the loss of ERalpha functions. This phenomenon is likely to be based on the mutually antagonistic relationship between ER and AhR.</p
Electrical detection of 31P spin quantum states
In recent years, a variety of solid-state qubits has been realized, including
quantum dots, superconducting tunnel junctions and point defects. Due to its
potential compatibility with existing microelectronics, the proposal by Kane
based on phosphorus donors in Si has also been pursued intensively. A key issue
of this concept is the readout of the P quantum state. While electrical
measurements of magnetic resonance have been performed on single spins, the
statistical nature of these experiments based on random telegraph noise
measurements has impeded the readout of single spin states. In this letter, we
demonstrate the measurement of the spin state of P donor electrons in silicon
and the observation of Rabi flops by purely electric means, accomplished by
coherent manipulation of spin-dependent charge carrier recombination between
the P donor and paramagnetic localized states at the Si/SiO2 interface via
pulsed electrically detected magnetic resonance. The electron spin information
is shown to be coupled through the hyperfine interaction with the P nucleus,
which demonstrates the feasibility of a recombination-based readout of nuclear
spins
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