Long-Term Outcome ofEn BlocExtensive Resection of the Penis and Prepuce Associated with a Permanent Perineal Urethrostomy in a Gelding Affected by Squamous Cell Carcinoma

A 15-year-old gelding was referred for a orid, cauli ower-like ulcerated mass, enclosing penis and prepuce together with penile urethra showing a malodorous purulent and blood-stained discharge and larvae infestation. En bloc extensive resection of the penis and prepuce, without penile retroversion or pexy to ventral abdomen associated with a permanent perineal urethrostomy, was performed. Histology of the mass revealed a squamous cell carcinoma of penis and prepuce. e surgical technique that was adopted is a modi ed version of that already described that allows a more proximal resection of the penile body and is a valid option for treating advanced SCC lesions involving the penis. Early postsurgical complications (mild strangury, haemorrhage from the urethrostomy site and its partial dehiscence, and infection of the abdominal wound) were managed with a medical treatment and resolved within 5 to 12 days. ree years a er surgery the horse is in good body condition and does not show any sign of recurrence or disorders related to the surgery

2D-SWE of the Metacarpophalangeal Joint Capsule in Horses

(1) Two-dimensional shear wave elastography (2D-SWE) employs an ultrasound impulse to produce transversely oriented shear waves, which travel through the surrounding tissue according to the stiffness of the tissue itself. The study aimed to assess the reliability of 2D-SWE for evaluating the elastosonographic appearance of the distal attachment of the fetlock joint capsule (DJC) in sound horses and in horses with osteoarthritis (OA) (2). According to a thorough evaluation of metacarpophalangeal joint (MCPJ), adult horses were divided in a sound Group (H) and in OA Group (P). Thereafter, a 2D-SWE of MCPJs was performed. Shear wave velocity (m/sec) and Young's modulus (kPa) were calculated independently by two operators at each selected ROI. Statistical analysis was performed with R software. (3) Results: 2D-SWE had good-excellent inter-CC and intra-CC in both groups. Differences in m/s and kPa between Groups H and P were found in transverse scans with lower values in Group P. No correlation with age or DJC thickness was found. (4) Conclusions: 2D-SWE was repeatable and reproducible. In Group H, DJC was statistically stiffer than in Group P only in transverse scan. The technique showed poor sensitivity and specificity in differentiating fetlocks affected by OA

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

Chirurgia endoscopica nel trattamento della tenosinovite asettica della guaina digitale nel cavallo: studio retrospettivo di 33 casi

Le fessurazioni longitudinali (FL) dei tendini fles- sori del dito rappresentano la principale causa di tenosinovite asettica della guaina digitale dei tendini flessori (GDTF) nel cavallo sportivo. La prognosi a lungo termine per il ripristino delle performances atletiche dopo trattamento medi- co e/o chirurgico è notoriamente riservata. In questo studio sono state revisionate le cartelle cliniche di 33 cavalli sottoposti a chirurgia teno- scopica per tenosinovite asettica della GDTF e sono stati verificati i risultati del trattamento dopo nove o più mesi dalla chirurgia. Sono sta- te esplorate endoscopicamente 34 GDTF e nel 79,4% (27/34) dei casi è stata rilevata la presen- za di una FL dei tendini flessori. Questa lesione è stata riscontrata più frequentemente a carico del tendine flessore profondo del dito (TFPD) in 25/27 casi (92,5%). L’esame ecografico pre- operatorio ha permesso di identificare le FL dei tendini flessori nel 59,2% dei casi (16/27). Le in- formazioni relative al follow-up sono state di- sponibili per 29 cavalli (30 GDTF). Il protocollo chirurgico adottato nella serie di casi presenta- ta in questo lavoro è risultato utile per la dia- gnosi definitiva e per il trattamento della teno- sinovite complessa della GDTF con una pro- gnosi complessiva favorevole per il ripristino delle performance atletiche nel 58,6% (17/29) dei soggetti, nonostante la letteratura interna- zionale più recente documenti prognosi meno favorevoli per alcuni tipi di lesione. Per quanto concerne le FL del TFPD 12/21 cavalli (57,1%) sono tornati a gareggiare dopo l’intervento ad un livello equivalente o superiore alle preceden- ti prestazioni sportive ed 1/21 soggetto al mo- mento della segnalazione è convalescente

COHORT RETROSPECTIVE STUDY ON DIAGNOSIS AND OUTCOME OF COLIC SYNDROME IN HORSES: PRELIMINARY DATA

Colic syndrome enrolles several disorders mainly involving the gastrointestinal apparatus and is a common cause of morbidity and mortality [1,2]. Several parameters are considered as predictor factors for the outcome, due to the multifactorial nature of the disorder and variability in horse population [3-6]. Aim of the study was to describe the characteristics, the clinical findings, diagnosis, treatment, and short term survival of horses referred for colic syndrome to the Veterinary Teaching Hospital of Teramo from 2005 to 2022. Collected data included patient signalment (age, gender, body weight, breed), time (morning, afternoon, night) and season of referral, type of treatment (medical, surgical), PCV, Total Protein, euthanasia, survival to discharge. Statistical analysis was carried out with R [7]. Frequency distribution of all discrete variables was provided as well as media, standard deviation (SD) for normally distributed continuous variables, median and interquartile range (IQR) for not-normally distributed continuous variables. One-hundred and fifty-seven horses were included (median age 10 years, IQR 7-13; body weight 550 kg, IQR 407-650). Thoroughbreds, Standardbreds, American and Spanish breeds were represented, as well as Frisian and Italian draft horses. Sixty-two were females (39.5%), 42/157 males (27%), 43/157 geldings (27.5%), 10/157 cases were unidentified (6%). Seventy-three were surgically (46,5%) and 81/157 conservativelly treated (51,5%), 3/157 cases were unidentified (2%). Thirty-nine were euthanized (25%), 5 died spontaneously, 106/157 survived to discharge (67%). In 7 cases the information was lost. When we considered as the outcome variable “survival to discharge”, only the explanatory variable”surgery” differed between the two groups. So a subdataset was considered involving only horses that were surgically treated. Horses receiving surgery were not different in age and body weight from those medically treated (t- test, p&gt;0.05). Hour and season of referral were statistically different between survived and not-survived horses (Fischer exact test, p&lt;0.05), with more survived horses referred in the afternoon and night, compared to the morning, and less survived horses refererred during winter compared to the other seasons. PCV was statistically lower in discharged horses (38.89% vs 48.17%), and time to standing after surgery shorter (58.61 vs 85.87) (t-test, p&lt;0.05). In discharged horses recovery score was better, and not-ischemic lesions were more represented (38 vs 19)(Fischer exact test, p&lt;0.05). No difference in discharge rate was observed according to the site of the lesion [large intestine 45/73 (61.64%), small intestine 22/73 (30.14%) or other sites 2/173(2.74%)], or to the administration of lidocaine after surgery (Fischer exact test, p&gt;0.05). Overall success rate (survival to discharge) of this observational study was in accordance with previous data, with the most common diagnosis being large colon disorders. Differently, we did not observe a higher rate of survival with this disorder compared to others. Hour and season of referral varied among survived and not-survived horses. A more extensive analysis involving an univariate and multivariate logistic regression model involving physical parameter at referral may be of use to highlight odd ratio for survival and help the clinician in the evaluation of prognosis in case of exploratory laparotomy

Cyst of the guttural pouch in a foal: a case report

Although cysts can occur anywhere in the equine upper airway, cysts of the guttural pouch are rare. The purpose of this report is to describe the clinical presentation, diagnostic procedure and surgical treatment of a guttural pouch cyst in a 16-day old Warmblood foal presenting with dysphagia. Endoscopic examination revealed a cyst protruding into the pharyngeal vault which was causing dysfunction of the pharynx and subsequent dysphagia. Surgical drainage in the pharynx was established by a transendoscopic fenestration of the cyst using a diode laser. The foal presented resolution of dysphagia and no recurrence 12 months following treatment. Foals with persistent dysphagia should receive a through endoscopic examination of the upper airways including the guttural pouches. In this case, the diagnosis and the surgical treatment of a guttural pouch canal cyst were successfully performed using a minimally invasive endoscopic approach

Segmental Posthetomy in a Four Stallions Case Series

Segmental posthetomy, also referred to as circumcision, reefing or posthioplasty, consists of removing a circumferential segment of the internal preputial lamina (internal preputial fold) followed by end-to-end anastomosis of skin edges. The purpose of this case series is to describe the successful outcome of segmental posthetomy for treating different diseases involving the internal or/and external preputial fold, while restoring the normal telescopic function. In this paper, we report the first case of complete degloving injury of the equine penis in the literature (case 1) and describe three different common lesions of the equine prepuce/penis (preputial scar tissue in case 2, preputial sarcoid in case 3 and penile/preputial wound in case 4). The amount of prepuce (safe minimums) that can be removed from a stallion without disrupting the proper telescopic function of the internal/external preputial fold and normal copulatory ability, has not been established. In this case series, all Equidae stallions maintained the telescopic function after preputial surgical resection. However, the surgeon must carefully evaluate every single case, especially when performing the Adam’s procedure