Chaos in Anisotropic Pre-Inflationary Universes

We study the dynamics of anisotropic Bianchi type-IX models with matter and cosmological constant. The models can be thought as describing the role of anisotropy in the early stages of inflation. The concurrence of the cosmological constant and anisotropy are sufficient to produce a chaotic dynamics in the gravitational degrees of freedom, connected to the presence of a critical point of saddle-center type in the phase space of the system. The invariant character of chaos is guaranteed by the topology of the cylinders emanating from unstable periodic orbits in the neighborhood of the saddle-center. We discuss a possible mechanism for amplification of specific wavelengths of inhomogeneous fluctuations in the models. A geometrical interpretation is given for Wald's inequality in terms of invariant tori and their destruction by increasing values of the cosmological constant.Comment: 14 pages, figures available under request. submitted to Physical Review

Influence of mechanical and geometrical properties of embedded long-gauge strain sensors on the accuracy of strain measurement

In many civil and geotechnical applications it is of interest to monitor the strain deep inside the structure; consequently, it is necessary to embed the sensors into the structure's material. Construction and geotechnical materials, such as concrete and soil, can be affected by local defects, e.g. cracks, air pockets and inclusions. To monitor these materials at a structural level it is necessary to use long-gauge sensors. As the sensor has to be embedded in the host material, its presence causes perturbation of the strain field and influences the accuracy of the strain measurement. The aim of this research was to identify the critical parameters that influence the accuracy of the strain measurement, to study how these parameters affect the accuracy, and to give recommendations for sensor users. The study was based on finite element analysis and all involved materials were assumed to have the MöhrCoulomb elastic, perfectly plastic behavior. A suitability of the numerical model for the analysis was verified using the experimental results of two cases reported in the literature and one on-site application. The study revealed that the most important parameters that influence the accuracy of the strain measurement are the goodness of interaction (strain transfer) between the host material and the anchor pieces of the sensor, the ratio between equivalent Young's modulus of the sensor and the Young's modulus of the host material, the radius of the anchor piece and the gauge length. The numerical model and parametric study are presented in detail along with practical recommendations. © 2012 IOP Publishing Ltd.The authors would like to thank the Spanish Ministry of Education, with support received under the National Program for Mobility of Researchers (O.M. EDU/1456/2010, ref. PR2010-0293) which enabled the joint work that made this study possible. The Streicker Bridge project was realized with help of Turner Construction Co., HNTB, AG Construction Corp., Vollers Excavating & Constr., SMARTEC SA, Micron Optics, Princeton Facilities, and staff and students of CEE department of Princeton University.Calderón García, PA.; Glisic, B. (2012). Influence of mechanical and geometrical properties of embedded long-gauge strain sensors on the accuracy of strain measurement. Measurement Science and Technology. (23):1-15. https://doi.org/10.1088/0957-0233/23/6/065604S11523Glišić, B., & Inaudi, D. (2007). Fibre Optic Methods for Structural Health Monitoring. doi:10.1002/9780470517819Ansari, F. (2007). Practical Implementation of Optical Fiber Sensors in Civil Structural Health Monitoring. Journal of Intelligent Material Systems and Structures, 18(8), 879-889. doi:10.1177/1045389x06075760Li, H.-N., Zhou, G.-D., Ren, L., & Li, D.-S. (2009). Strain Transfer Coefficient Analyses for Embedded Fiber Bragg Grating Sensors in Different Host Materials. Journal of Engineering Mechanics, 135(12), 1343-1353. doi:10.1061/(asce)0733-9399(2009)135:12(1343)Torres, B., Payá-Zaforteza, I., Calderón, P. A., & Adam, J. M. (2011). Analysis of the strain transfer in a new FBG sensor for Structural Health Monitoring. Engineering Structures, 33(2), 539-548. doi:10.1016/j.engstruct.2010.11.012Kesavan, K., Ravisankar, K., Parivallal, S., Sreeshylam, P., & Sridhar, S. (2010). Experimental studies on fiber optic sensors embedded in concrete. Measurement, 43(2), 157-163. doi:10.1016/j.measurement.2009.08.010Azenha, M., Faria, R., & Ferreira, D. (2009). Identification of early-age concrete temperatures and strains: Monitoring and numerical simulation. Cement and Concrete Composites, 31(6), 369-378. doi:10.1016/j.cemconcomp.2009.03.004Glisic, B. (2011). Influence of the gauge length on the accuracy of long-gauge sensors employed in monitoring of prismatic beams. Measurement Science and Technology, 22(3), 035206. doi:10.1088/0957-0233/22/3/035206Leng, J. S., Winter, D., Barnes, R. A., Mays, G. C., & Fernando, G. F. (2006). Structural health monitoring of concrete cylinders using protected fibre optic sensors. Smart Materials and Structures, 15(2), 302-308. doi:10.1088/0964-1726/15/2/009Calderón, P. A., Adam, J. M., Ivorra, S., Pallarés, F. J., & Giménez, E. (2009). Design strength of axially loaded RC columns strengthened by steel caging. Materials & Design, 30(10), 4069-4080. doi:10.1016/j.matdes.2009.05.014Adam, J. M., Ivorra, S., Pallarés, F. J., Giménez, E., & Calderón, P. A. (2009). Axially loaded RC columns strengthened by steel caging. Finite element modelling. Construction and Building Materials, 23(6), 2265-2276. doi:10.1016/j.conbuildmat.2008.11.014Adam, J. M., Ivorra, S., Pallares, F. J., Jiménez, E., & Calderón, P. A. (2008). Column–joint assembly in RC columns strengthened by steel caging. Proceedings of the Institution of Civil Engineers - Structures and Buildings, 161(6), 337-348. doi:10.1680/stbu.2008.161.6.337Adam, J. M., Ivorra, S., Pallares, F. J., Giménez, E., & Calderón, P. A. (2009). Axially loaded RC columns strengthened by steel cages. Proceedings of the Institution of Civil Engineers - Structures and Buildings, 162(3), 199-208. doi:10.1680/stbu.2009.162.3.199Johansson, M., & Gylltoft, K. (2001). Structural behavior of slender circular steel-concrete composite columns under various means of load application. Steel and Composite Structures, 1(4), 393-410. doi:10.12989/scs.2001.1.4.393Johansson, M., & Gylltoft, K. (2002). Mechanical Behavior of Circular Steel–Concrete Composite Stub Columns. Journal of Structural Engineering, 128(8), 1073-1081. doi:10.1061/(asce)0733-9445(2002)128:8(1073

Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation

In 1997, the first consensus guidelines for haematopoietic SCT (HSCT) in autoimmune diseases (ADs) were published, while an international coordinated clinical programme was launched. These guidelines provided broad principles for the field over the following decade and were accompanied by comprehensive data collection in the European Group for Blood and Marrow Transplantation (EBMT) AD Registry. Subsequently, retrospective analyses and prospective phase I/II studies generated evidence to support the feasibility, safety and efficacy of HSCT in several types of severe, treatment-resistant ADs, which became the basis for larger-scale phase II and III studies. In parallel, there has also been an era of immense progress in biological therapy in ADs. The aim of this document is to provide revised and updated guidelines for both the current application and future development of HSCT in ADs in relation to the benefits, risks and health economic considerations of other modern treatments. Patient safety considerations are central to guidance on patient selection and HSCT procedural aspects within appropriately experienced and Joint Accreditation Committee of International Society for Cellular Therapy and EBMT accredited centres. A need for prospective interventional and non-interventional studies, where feasible, along with systematic data reporting, in accordance with EBMT policies and procedures, is emphasized