52 research outputs found
Effect of surfactant replacement on Pneumocystis carinii pneumonia in rats
The effect of intratracheal surfactant instillation on pulmonary function in rats with Pneumocystis carinii pneumonia (PCP) was investigated. In those animals which developed PCP with severe respiratory failure after administration of cortisone acetate s. c. over 8-12 weeks, pulmonary function was improved by surfactant instillation. PaO2 values 30 min after surfactant instillation were significantly higher compared to pretreatment values and also compared to PaO2 values of rats 30 min after receiving saline (482.9 mmHg±44.7, 170.7 mmHg ±39.3 and 67.2 mmHg±17.4, respectively). Histological examination showed that alveoli of rats with PCP which received no exogenous surfactant are filled with foamy edema, whereas after exogenous surfactant alveoli are stabilized and well-aerated. These results indicate that exogenous surfactant may help patients with severe PCP to overcome an acute stage of respiratory distress
Perceptions of clinicians and staff about the use of digital technology in primary care: qualitative interviews prior to implementation of a computer-facilitated 5As intervention
Raynaud phenomenon in three patients with acquired immune deficiency syndrome-related kaposi sarcoma treated with bleomycin
Changes in Ciprofloxacin Utilization as Shown in a Large Pharmacy Claims Database: Effects of Proximity to Criminal Anthrax Exposure in October 2001
Emerging Infectious Diseases in the United States: Improved Surveillance, a Requisite for Prevention
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