985 research outputs found
Properties of Galaxies in and around Voids
Two surveys for intrinsically faint galaxies towards nearby voids have been
conducted at the MPI f\"ur Astronomie, Heidelberg. One selected targets from a
new diameter limited () catalog with morphological criteria while
the other used digitized objective prism Schmidt plates to select mainly HII
dwarf galaxies. For some 450 galaxies, redshifts and other optical data were
obtained. We studied the spatial distribution of the sample objects, their
luminosity function, and their intrinsic properties. Most of the galaxies
belong to already well known sheets and filaments. But we found about a dozen
highly isolated galaxies in each sample (nearest neighborhood distance ). These tend to populate additional structures and are not
distributed homogeneously throughout the voids. As our results on 'void
galaxies' still suffer from small sample statistics, I also tried to combine
similar existing surveys of nearby voids to get further hints on the larger
structure and on the luminosity function of the isolated galaxies. No
differences in the luminosity function of sheet and void galaxies could be
found. The optical and infrared properties of both samples are in the normal
range for samples dominated by late-type dwarfs. Follow-up HI studies show that
the isolated dwarfs in both samples have unusual high amount of neutral gas for
a given luminosity.Comment: 10 pages, 4 figures, latex, to appear in the proceedings of the
'Ringberg workshop on Large Scale Structure', hold Sep. 23-28, 199
Fossil Carder Bee's nest from the Hominin locality of Taung, South Africa
The Buxton-Norlim Limeworks southwest of Taung, South Africa, is renowned for the discovery of the first Australopithecus africanus fossil, the ‘Taung Child’. The hominin was recovered from a distinctive pink calcrete that contains an abundance of invertebrate ichnofauna belonging to the Coprinisphaera ichnofacies. Here we describe the first fossil bee’s nest, attributed to the ichnogenus Celliforma, from the Plio-Pleistocene of Africa. Petrographic examination of a cell lining revealed the preservation of an intricate organic matrix lined with the calcitic casts of numerous plant trichomes–a nesting behaviour unique to the modern-day carder bees (Anthidiini). The presence of Celliforma considered alongside several other recorded ichnofossils can be indicative of a dry, savannah environment, in agreement with recent work on the palaeoenvironment of Plio-Pleistocene southern Africa. Moreover, the occurrence of ground-nesting bees provides further evidence that the pink calcrete deposits are of pedogenic origin, rather than speleogenic origin as has previously been assumed. This study demonstrates the potential value of insect trace fossils as palaeoenvironmental indicators
Exoplanets and SETI
The discovery of exoplanets has both focused and expanded the search for
extraterrestrial intelligence. The consideration of Earth as an exoplanet, the
knowledge of the orbital parameters of individual exoplanets, and our new
understanding of the prevalence of exoplanets throughout the galaxy have all
altered the search strategies of communication SETI efforts, by inspiring new
"Schelling points" (i.e. optimal search strategies for beacons). Future efforts
to characterize individual planets photometrically and spectroscopically, with
imaging and via transit, will also allow for searches for a variety of
technosignatures on their surfaces, in their atmospheres, and in orbit around
them. In the near-term, searches for new planetary systems might even turn up
free-floating megastructures.Comment: 9 page invited review. v2 adds some references and v3 has other minor
additions and modification
Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data
Background: MicroRNAs (miRNAs) are short, non-coding RNA regulators of protein coding genes. miRNAs play a very important role in diverse biological processes and various diseases. Many algorithms are able to predict miRNA genes and their targets, but their transcription regulation is still under investigation. It is generally believed that intragenic miRNAs (located in introns or exons of protein coding genes) are co-transcribed with their host genes and most intergenic miRNAs transcribed from their own RNA polymerase II (Pol II) promoter. However, the length of the primary transcripts and promoter organization is currently unknown. Methodology: We performed Pol II chromatin immunoprecipitation (ChIP)-chip using a custom array surrounding regions of known miRNA genes. To identify the true core transcription start sites of the miRNA genes we developed a new tool (CPPP). We showed that miRNA genes can be transcribed from promoters located several kilobases away and that their promoters share the same general features as those of protein coding genes. Finally, we found evidence that as many as 26% of the intragenic miRNAs may be transcribed from their own unique promoters. Conclusion: miRNA promoters have similar features to those of protein coding genes, but miRNA transcript organization is more complex. © 2009 Corcoran et al
Indexing Strategies for Rapid Searches of Short Words in Genome Sequences
Searching for matches between large collections of short (14–30 nucleotides) words and sequence databases comprising full genomes or transcriptomes is a common task in biological sequence analysis. We investigated the performance of simple indexing strategies for handling such tasks and developed two programs, fetchGWI and tagger, that index either the database or the query set. Either strategy outperforms megablast for searches with more than 10,000 probes. FetchGWI is shown to be a versatile tool for rapidly searching multiple genomes, whose performance is limited in most cases by the speed of access to the filesystem. We have made publicly available a Web interface for searching the human, mouse, and several other genomes and transcriptomes with oligonucleotide queries
NLO QCD corrections to tW' and tZ' production in forward-backward asymmetry models
We consider Z' and W' models recently proposed to explain the top
forward-backward asymmetry at the Tevatron. We present the next-to-leading
order QCD corrections to associated production of such vector bosons together
with top quarks at the Large Hadron Collider, for centre-of-mass energies of 7
and 8 TeV. The corrections are significant, modifying the total production
cross-section by 30-50%. We consider the effects of the corrections on the top
and vector-boson kinematics. The results are directly applicable to current
experimental searches, for both the ATLAS and CMS collaborations.Comment: 62 pages, 13 figures, 36 tables. v3 Updated to correspond to Journal
version and incorporate supplementary materia
Primer to Voltage Imaging With ANNINE Dyes and Two-Photon Microscopy
ANNINE-6 and ANNINE-6plus are voltage-sensitive dyes that when combined with two-photon microscopy are ideal for recording of neuronal voltages in vivo, in both bulk loaded tissue and the dendrites of single neurons. Here, we describe in detail but for a broad audience the voltage sensing mechanism of fast voltage-sensitive dyes, with a focus on ANNINE dyes, and how voltage imaging can be optimized with one-photon and two-photon excitation. Under optimized imaging conditions the key strengths of ANNINE dyes are their high sensitivity (0.5%/mV), neglectable bleaching and phototoxicity, a linear response to membrane potential, and a temporal resolution which is faster than the optical imaging devices currently used in neurobiology (order of nanoseconds). ANNINE dyes in combination with two-photon microscopy allow depth-resolved voltage imaging in bulk loaded tissue to study average membrane voltage oscillations and sensory responses. Alternatively, if ANNINE-6plus is applied internally, supra and sub threshold voltage changes can be recorded from dendrites of single neurons in awake animals. Interestingly, in our experience ANNINE-6plus labeling is impressively stable in vivo, such that voltage imaging from single Purkinje neuron dendrites can be performed for 2 weeks after a single electroporation of the neuron. Finally, to maximize their potential for neuroscience studies, voltage imaging with ANNINE dyes and two-photon microscopy can be combined with electrophysiological recording, calcium imaging, and/or pharmacology, even in awake animals
Behavioral Modernity and the Cultural Transmission of Structured Information: The Semantic Axelrod Model
Cultural transmission models are coming to the fore in explaining increases
in the Paleolithic toolkit richness and diversity. During the later
Paleolithic, technologies increase not only in terms of diversity but also in
their complexity and interdependence. As Mesoudi and O'Brien (2008) have shown,
selection broadly favors social learning of information that is hierarchical
and structured, and multiple studies have demonstrated that teaching within a
social learning environment can increase fitness. We believe that teaching also
provides the scaffolding for transmission of more complex cultural traits.
Here, we introduce an extension of the Axelrod (1997} model of cultural
differentiation in which traits have prerequisite relationships, and where
social learning is dependent upon the ordering of those prerequisites. We
examine the resulting structure of cultural repertoires as learning
environments range from largely unstructured imitation, to structured teaching
of necessary prerequisites, and we find that in combination with individual
learning and innovation, high probabilities of teaching prerequisites leads to
richer cultural repertoires. Our results point to ways in which we can build
more comprehensive explanations of the archaeological record of the Paleolithic
as well as other cases of technological change.Comment: 24 pages, 7 figures. Submitted to "Learning Strategies and Cultural
Evolution during the Paleolithic", edited by Kenichi Aoki and Alex Mesoudi,
and presented at the 79th Annual Meeting of the Society for American
Archaeology, Austin TX. Revised 5/14/1
The evolutionary roots of creativity: mechanisms and motivations
Funding: MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland). MASTS is funded by the Scottish Funding Council (grant reference HR09011) and contributing institutions.We consider the evolution of cognition and the emergence of creative behaviour, in relation to vocal communication. We address two key questions: (i) what cognitive and/or social mechanisms have evolved that afford aspects of creativity?; (ii) has natural and/or sexual selection favoured human behaviours considered ‘creative’? This entails analysis of ‘creativity’, an imprecise construct: comparable properties in non-humans differ in magnitude and teleology from generally agreed human creativity. We then address two apparent problems: (i) the difference between merely novel productions and ‘creative’ ones; (ii) the emergence of creative behaviour in spite of high cost: does it fit the idea that females choose a male who succeeds in spite of a handicap (costly ornament); or that creative males capable of producing a large and complex song repertoire grew up under favourable conditions; or a demonstration of generally beneficial heightened reasoning capacity; or an opportunity to continually reinforce social bonding through changing communication tropes; or something else? We illustrate and support our argument by reference to whale and bird song; these independently evolved biological signal mechanisms objectively share surface properties with human behaviours generally called ‘creative’. Studying them may elucidate mechanisms underlying human creativity; we outline a research programme to do so.PostprintPeer reviewe
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