Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102104/1/emboj7601065.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102104/2/emboj7601065-sup-0001.pd

Rab8a regulates the exocyst-mediated kiss-and-run discharge of the Dictyostelium contractile vacuole

A molecular dissection of contractile vacuole (CV) discharge shows that Rab8a is recruited to the CV a few seconds before the exocyst. Together they tether it to the plasma membrane and commit it to fusion. GTP hydrolysis is necessary for vacuole detethering, a process in which LvsA, a protein of the Chédiak–Higashi family, plays a crucial role