173 research outputs found
Pseudonymization risk analysis in distributed systems
In an era of big data, online services are becoming increasingly data-centric; they collect, process, analyze and anonymously disclose growing amounts of personal data in the form of pseudonymized data sets. It is crucial that such systems are engineered to both protect individual user (data subject) privacy and give back control of personal data to the user. In terms of pseudonymized data this means that unwanted individuals should not be able to deduce sensitive information about the user. However, the plethora of pseudonymization algorithms and tuneable parameters that currently exist make it difficult for a non expert developer (data controller) to understand and realise strong privacy guarantees. In this paper we propose a principled Model-Driven Engineering (MDE) framework to model data services in terms of their pseudonymization strategies and identify the risks to breaches of user privacy. A developer can explore alternative pseudonymization strategies to determine the effectiveness of their pseudonymization strategy in terms of quantifiable metrics: i) violations of privacy requirements for every user in the current data set; ii) the trade-off between conforming to these requirements and the usefulness of the data for its intended purposes. We demonstrate through an experimental evaluation that the information provided by the framework is useful, particularly in complex situations where privacy requirements are different for different users, and can inform decisions to optimize a chosen strategy in comparison to applying an off-the-shelf algorithm
Dietary behaviors related to cancer prevention among pre-adolescents and adolescents: the gap between recommendations and reality
<p>Abstract</p> <p>Background</p> <p>Diet is thought to play an important role in cancer risk. This paper summarizes dietary recommendations for cancer prevention and compares these recommendations to the dietary behaviors of U.S. youth ages 8-18.</p> <p>Methods</p> <p>We identified cancer prevention-related dietary recommendations from key health organizations and assessed dietary consumption patterns among youth using published statistics from the National Health and Nutrition Examination Survey, the national Youth Risk Behavior Survey, and other supplemental sources.</p> <p>Results</p> <p>Cancer prevention guidelines recommend a diet rich in fruits, vegetables, and whole grains, recommend limiting sugary foods and beverages, red and processed meats, sodium, and alcohol, and recommend avoiding foods contaminated with carcinogens. However, youth typically do not meet the daily recommendations for fruit, vegetable, or whole grain consumption and are over-consuming energy-dense, sugary and salty foods.</p> <p>Conclusions</p> <p>A large discrepancy exists between expert recommendations about diet and cancer and actual dietary practices among young people and points to the need for more research to better promote the translation of science into practice. Future research should focus on developing and evaluating policies and interventions at the community, state and national levels for aligning the diets of youth with the evolving scientific evidence regarding cancer prevention.</p
Nanoscale Metallic Iron for Environmental Remediation: Prospects and Limitations
The amendment of the subsurface with nanoscale metallic iron particles
(nano-Fe0) has been discussed in the literature as an efficient in situ
technology for groundwater remediation. However, the introduction of this
technology was controversial and its efficiency has never been univocally
established. This unsatisfying situation has motivated this communication whose
objective was a comprehensive discussion of the intrinsic reactivity of
nano-Fe0 based on the contemporary knowledge on the mechanism of contaminant
removal by Fe0 and a mathematical model. It is showed that due to limitations
of the mass transfer of nano-Fe0 to contaminants, available concepts cannot
explain the success of nano-Fe0 injection for in situ groundwater remediation.
It is recommended to test the possibility of introducing nano-Fe0 to initiate
the formation of roll-fronts which propagation would induce the reductive
transformation of both dissolved and adsorbed contaminants. Within a
roll-front, FeII from nano-Fe0 is the reducing agent for contaminants. FeII is
recycled by biotic or abiotic FeIII reduction. While the roll-front concept
could explain the success of already implemented reaction zones, more research
is needed for a science-based recommendation of nano- Fe0 for subsurface
treatment by roll-front
Eligibility for PCSK9 treatment in 734 Hypercholesterolemic patients referred to a regional cholesterol treatment center with LDL cholesterol ≥70 mg/dl despite maximal tolerated cholesterol lowering therapy
Riesgo cardiovascular en estudiantes de medicina del municipio Puerto Padre de Las Tunas
Introduction: cardiovascular diseases are the first cause of death in Cuba; as a result, the identification of cardiovascular risks from early ages allows the implementation of health promotion and prevention strategies to reduce their impact in the futureObjective: to identify the cardiovascular risk in medical students in Puerto Padre Municipality, Las Tunas province.Methods: an observational, descriptive and cross-sectional study was conducted. The target group included 545 medical students, 237 of whom were selected by means of a simple random sample. The body mass index and waist-hip ratio were studied. Descriptive statistics was applied.Results: the predominant age group was 18-21 years old (50,2 %). The 51,47 % of the students presented a high waist-hip ratio, 54,02 % a high abdominal circumference, 52,74 % a high body mass index, and in all groups 35,44 % presented blood pressure figures lower than 120/80 mmHg; 39 % had a cardiovascular risk.Conclusions: low percentages of cardiovascular risk were identified in medical students from Puerto Padre Municipality, Las Tunas province, determined by high values of waist-hip index, body mass index and abdominal circumference.Introducción: las enfermedades cardiovasculares constituyen la primera causa de mortalidad en Cuba; por lo cual la identificación de riesgos cardiovasculares desde edades tempranas permite implementar estrategias de promoción y prevención de salud para disminuir su impacto en el futuroObjetivo: identificar el riesgo cardiovascular en estudiantes de medicina del municipio Puerto Padre de Las Tunas.Método: se realizó un estudio observacional, descriptivo y transversal. El universo estuvo constituido por 545 estudiantes de medicina, seleccionándose 237 mediante un muestreo aleatorio simple. Se estudió el índice de masa corporal, la circunferencia abdominal y la índice cintura cadera. Se empleó estadística descriptiva.Resultados: se encontró predominio del grupo etario de 18 a 21 años (50,2 %). El 51,47 % de los estudiantes presentó un índice cintura-cadera alto, el 54,02 % una circunferencia abdominal alta, el 52,74 % un índice de masa corporal alta, así como en todos los grupos el 35,44 % presentó cifras de tensión arterial inferiores a 120/80 mmHg. El 39 % presentó riesgo cardiovascular.Conclusiones: se identificaron bajos porcientos de riesgo cardiovascular en los estudiantes de medicina del municipio Puerto Padre de Las Tunas, determinado por altos valores los índice cintura-cadera, índice de masa corporal y circunferencia abdominal
Limited sampling strategies for accurate determination of extended half‐life factor VIII pharmacokinetics in severe haemophilia A patients
Sacituzumab Govitecan-hziy: An Antibody-Drug Conjugate for the Treatment of Refractory, Metastatic, Triple-Negative Breast Cancer
Pharmacokinetic implications of dosing emicizumab based on vial size: A simulation study
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