81 research outputs found
Combination of linear classifiers using score function -- analysis of possible combination strategies
In this work, we addressed the issue of combining linear classifiers using
their score functions. The value of the scoring function depends on the
distance from the decision boundary. Two score functions have been tested and
four different combination strategies were investigated. During the
experimental study, the proposed approach was applied to the heterogeneous
ensemble and it was compared to two reference methods -- majority voting and
model averaging respectively. The comparison was made in terms of seven
different quality criteria. The result shows that combination strategies based
on simple average, and trimmed average are the best combination strategies of
the geometrical combination
Efficacy of benznidazol treatment for asymptomatic chagasic patients from state of Rio Grande do Sul evaluated during a three years follow-up
N >= 4 Supergravity Amplitudes from Gauge Theory at Two Loops
We present the full two-loop four-graviton amplitudes in N=4,5,6
supergravity. These results were obtained using the double-copy structure of
gravity, which follows from the recently conjectured color-kinematics duality
in gauge theory. The two-loop four-gluon scattering amplitudes in N=0,1,2
supersymmetric gauge theory are a second essential ingredient. The gravity
amplitudes have the expected infrared behavior: the two-loop divergences are
given in terms of the squares of the corresponding one-loop amplitudes. The
finite remainders are presented in a compact form. The finite remainder for N=8
supergravity is also presented, in a form that utilizes a pure function with a
very simple symbol.Comment: 31 pages, 2 figures, 1 table. v2: minor corrections, and references
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A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention
An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection
The airway epithelium secretes proteins that function in innate defense against
infection. BPI fold-containing family member A1 (BPIFA1) is secreted into airways
and has a protective role during bacterial infections, but it is not known whether it
also has an antiviral role. To determine a role in host defense against influenza A
virus (IAV) infection and to find the underlying defense mechanism we developed
transgenic mouse models that are deficient in BPIFA1 and used these, in
combination with in vitro 3D mouse tracheal epithelial cell (mTEC) cultures, to
investigate its antiviral properties. We show that BPIFA1 has a significant role in
mucosal defense against IAV infection. BPIFA1 secretion was highly modulated after
IAV infection. Mice deficient in BPIFA1 lost more weight after infection, supported a
higher viral load and virus reached the peripheral lung earlier, indicative of a defect
in the control of infection. Further analysis using mTEC cultures showed that
BPIFA1-deficient cells bound more virus particles, displayed increased nuclear
import of IAV ribonucleoprotein complexes and supported higher levels of viral
replication. Our results identify a critical role for BPIFA1 in the initial phase of
infection by inhibiting the binding and entry of IAV into airway epithelial cells
A systematic review of the role of school-based healthcare in adolescent sexual, reproductive, and mental health
HIV Aspartyl Peptidase Inhibitors Interfere with Cellular Proliferation, Ultrastructure and Macrophage Infection of Leishmania amazonensis
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Previous issue date: 2009Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral,. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral,. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Microbiologia Geral,. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil.Leishmania is the etiologic agent of leishmanisais, a protozoan disease whose pathogenic events are not well understood. Current therapy is suboptimal due to toxicity of the available therapeutic agents and the emergence of drug resistance. Compounding these problems is the increase in the number of cases of Leishmania-HIV coinfection, due to the overlap between the AIDS epidemic and leishmaniasis
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