Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers

<p>Abstract</p> <p>Background</p> <p>Variation in ADAM33 has been shown to be important in the development of asthma and altered lung function. This relationship however, has not been investigated in the population susceptible to COPD; long term tobacco smokers. We evaluated the association between polymorphisms in ADAM33 gene with COPD and lung function in long term tobacco smokers.</p> <p>Methods</p> <p>Caucasian subjects, at least 50 year old, who smoked ≥ 20 pack-years (n = 880) were genotyped for 25 single nucleotide polymorphisms (SNPs) in ADAM33. COPD was defined as an FEV1/FVC ratio < 70% and percent-predicted (pp)FEV1 < 75% (n = 287). The control group had an FEV1/FVC ratio ≥ 70% and ppFEV₁≥ 80% (n = 311) despite ≥ 20 pack years of smoking. Logistic and linear regressions were used for the analysis. Age, sex, and smoking status were considered as potential confounders.</p> <p>Results</p> <p>Five SNPs in ADAM33 were associated with COPD (Q-1, intronic: p < 0.003; S1, Ile → Val: p < 0.003; S2, Gly → Gly: p < 0.04; V-1 intronic: p < 0.002; V4, in 3' untranslated region: p < 0.007). Q-1, S1 and V-1 were also associated with ppFEV1, FEV1/FVC ratio and ppFEF25–75 (p values 0.001 – 0.02). S2 was associated with FEV1/FVC ratio (p < 0.05). The association between S1 and residual volume revealed a trend toward significance (p value < 0.07). Linkage disequilibrium and haplotype analyses suggested that S1 had the strongest degree of association with COPD and pulmonary function abnormalities.</p> <p>Conclusion</p> <p>Five SNPs in ADAM33 were associated with COPD and lung function in long-term smokers. Functional studies will be needed to evaluate the biologic significance of these polymorphisms in the pathogenesis of COPD.</p

Cost-effectiveness of Cardiovascular Imaging for Stable Coronary Heart Disease

Objective: To assess the cost-effectiveness of management strategies for patients presenting with chest pain and suspected coronary heart disease (CHD): i) cardiovascular magnetic resonance (CMR); (ii) myocardial perfusion scintigraphy (MPS); and (iii) UK National Institute for Health and Care Excellence (NICE) guideline-guided care. Methods: Using UK data for 1,202 patients from the Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease 2 trial, we conducted an economic evaluation to assess the cost-effectiveness of CMR, MPS and NICE guidelines. Health outcomes were expressed as quality-adjusted life-years (QALY) and costs reflected UK pounds sterling 2016-17. Cost-effectiveness results were presented as incremental cost-effectiveness ratios and incremental net health benefits overall and for low, medium, and high pre-test likelihood of CHD subgroups. Results: CMR had the highest estimated QALY gain overall (2.21 [95% credible interval 2.15,2.26] compared to 2.07 [1.92,2.20] NICE and 2.11 [2.01,2.22] MPS) and incurred comparable costs (overall £1625 [£1431,£1824] compared to £1753 [£1473,£2032] NICE and £1768 [£1572,£1989] MPS). Overall, CMR was the cost-effective strategy, being the dominant strategy (more effective less costly) with incremental net health benefits per patient of 0.146 QALYs [-0.18,0.406] compared to NICE guidelines at a cost-effectiveness threshold of £15,000/QALY (93% probability of cost-effectiveness). Results were similar in the pre-test likelihood subgroups. Conclusions: CMR guided care is cost-effective overall and across all pre-test likelihood subgroups, compared to MPS and NICE guidelines

Measuring the impact of cancer: a comparison of non-Hodgkin lymphoma and breast cancer survivors

Introduction Self-report instruments such as the Impact of Cancer (IOC) are designed to measure quality of life (QOL) impacts that cancer survivors attribute to their cancer experience. Generalizability of QOL findings across dis-tinct diagnostic categories of survivors is untested. W

Assessment of Objectively Measured Physical Activity Levels in Individuals with Intellectual Disabilities with and without Down's Syndrome

Objective: To investigate, using accelerometers, the levels of physical activity being undertaken by individuals with intellectual disabilities with and without Down’s syndrome. Methods: One hundred and fifty two individuals with intellectual disabilities aged 12–70 years from East and South-East England. Physical activity levels in counts per minute (counts/min), steps per day (steps/day), and minutes of sedentary, light, moderate, vigorous, and moderate to vigorous physical activity (MVPA) measured with a uni-axial accelerometer (Actigraph GT1M) for seven days. Results: No individuals with intellectual disabilities met current physical activity recommendations. Males were more active than females. There was a trend for physical activity to decline and sedentary behaviour to increase with age, and for those with more severe levels of intellectual disability to be more sedentary and less physically active, however any relationship was not significant when adjusted for confounding variables. Participants with Down’s syndrome engaged in significantly less physical activity than those with intellectual disabilities without Down’s syndrome and levels of activity declined significantly with age. Conclusions: Individuals with intellectual disabilities, especially those with Down’s syndrome may be at risk of developing diseases associated with physical inactivity. There is a need for well-designed, accessible, preventive health promotio

Micro-CT imaging reveals<i> Mekk3 </i>heterozygosity prevents cerebral cavernous malformations in <i>Ccm2</i>-deficient mice

Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic approaches for CCM disease. However, the full value of these animal models is limited by the lack of an accurate and quantitative method to assess lesion burden and progression. In the present study we have established a refined and detailed contrast enhanced X-ray micro-CT method to measure CCM lesion burden in mouse brains. As this study utilized a voxel dimension of 9.5μm (leading to a minimum feature size of approximately 25μm), it is therefore sufficient to measure CCM lesion volume and number globally and accurately, and provide high-resolution 3-D mapping of CCM lesions in mouse brains. Using this method, we found loss of Ccm1 or Ccm2 in neonatal endothelium confers CCM lesions in the mouse hindbrain with similar total volume and number. This quantitative approach also demonstrated a rescue of CCM lesions with simultaneous deletion of one allele of Mekk3. This method would enhance the value of the established mouse models to study the molecular basis and potential therapies for CCM and other cerebrovascular diseases

Wellbeing indicators affecting female entrepreneurship in OECD countries

[EN] The objective of this research is to know which wellbeing indicators, such as work-life balance, educational level, income or job security, are related to the rate of female entrepreneurship in 29 OECD countries. In addition, these countries have been classified according to the motivation of the entrepreneur either by necessity or by opportunity. The empiric study is focused on 29 OECD countries covering the different geographic areas (Western Europe, Central and Eastern Europe, Middle East, etc.) Due to the fact that the sample is relatively small, it is essential to use a selective approach when selecting the causal conditions. To this end, fsQCA is the most appropriate methodology for such a small data set. A total of 5 variables have been used: an independent variable (female TEA ratio), and four dependent variables (work life balance, educational level, sustainable household income and job security). Data measuring female TEA ratio have been obtained from Global Entrepreneur Monitor (GEM in Global report, 2015) data base, while data measuring wellbeing dimensions were taken from the Better Life Index (OECD in How¿s life? Measuring wellbeing, 2015. http://www.oecdbetterlifeindex.org). The results of this piece of research show that countries with high sustainable household income together with high level of education achieves high female entrepreneurship ratio with both, a good work-life balance (despite of a high unemployment probability), or a high labour-personal imbalance (in this latter, with a low probability of unemployment).This work has been funded by the R + D project for emerging research groups with reference (GVA) GV/2016/078.Ribes-Giner, G.; Moya Clemente, I.; Cervelló Royo, RE.; Perelló Marín, MR. (2019). Wellbeing indicators affecting female entrepreneurship in OECD countries. Quality & Quantity. 53(2):915-933. https://doi.org/10.1007/s11135-018-0796-4S915933532Ahl, H., Nelson, T.: How policy positions women entrepreneurs: a comparative analysis of state discourse in Sweden and the United States. J. Bus. Ventur. 30(2), 273–291 (2015). https://doi.org/10.1016/j.jbusvent.2014.08.002Andersson, P.: Happiness and health: wellbeing among the self-employed. J. Socio-Econ. 37(1), 213–236 (2008). https://doi.org/10.1016/j.socec.2007.03.003Bardasi, E., Sabarwal, S., Terrell, K.: How do female entrepreneurs perform? Evidence from three developing regions. Small Bus. Econ. 37(4), 417–441 (2011). https://doi.org/10.1007/s11187-011-9374-zBergheim, S., Schneider, S., Giesel, B., Walter, N.: Measures of Wellbeing. There is More to it Than GDP. Deutsche Bank Research, Frankfurt (2006)Berglund, H.: Between cognition and discourse: phenomenology and the study of entrepreneurship. Int. J. Entrep. Behav. Res. 21(3), 472–488 (2015). https://doi.org/10.1108/IJEBR-12-2013-0210Bianchi, M., Parisi, V., Salvatore, R.: Female entrepreneurs: motivations and constraints. An Italian regional study. Int. J. Gend. Entrep. 8(3), 198–220 (2016). https://doi.org/10.1108/IJGE-08-2015-0029Bittencourt Marconatto, D.A., Barin-Cruz, L., Pozzebon, M., Poitras, J.E.: Developing sustainable business models within BOP contexts: mobilizing native capability to cope with government programs. J. Clean. Prod. 129, 735–748 (2016). https://doi.org/10.1016/j.jclepro.2016.03.038Boarini, R., Comola, M., Smith, C., Manchin, R., de Keulenaer, F.: What makes for a better life? The determinants of subjective well-being in OECD countries—evidence from the Gallup World Poll. OECD statistics working papers, 2012(3), 0_1 (2012). https://doi.org/10.1787/5k9b9ltjm937-enBoarini, R., D’Ercole, M.M.: Going beyond GDP: an OECD perspective. Fisc. Stud. 34(3), 289–314 (2013). https://doi.org/10.1111/j.1475-5890.2013.12007.xBradshaw, J., Hoelscher, P., Richardson, D. (eds.): Comparing child well-being in OECD countries: Concepts and methods. Innocenti working paper, IWP-2006-03. UNICEF Innocenti Research Centre, Florence, Italy (2007)Brindley, C.: Barriers to women achieving their entrepreneurial potential. Int. J. Entrep. Behav. Res. Emerald Group Publishing Limited (2005). Retrieved from http://www.emeraldinsight.com/doi/full/10.1108/13552550510590554Burke, A.E., Fitzroy, F.R., Nolan, M.A.: What makes a die-hard entrepreneur? Beyond the “employee or entrepreneur” dichotomy. Small Bus. Econ. 31(2), 93–115 (2008). https://doi.org/10.1007/s11187-007-9086-6Buttner, H.E., Moore, D.P.: Women’s organizational exodus to entrepreneurship: self-reported motivations and correlates with success. J. Small Bus. Manag. 35(1), 34–46 (1997). Retrieved from http://search.ebscohost.comCarter, S.: The rewards of entrepreneurship: exploring the incomes, wealth, and economic wellbeing of entrepreneurial households. Entrep. Theory Pract. 35(1), 39–55 (2011)Castaño, M.-S., Méndez, M.-T., Galindo, M.Á.: The effect of social, cultural, and economic factors on entrepreneurship. J. Bus. Res. 68(7), 1496–1500 (2015). https://doi.org/10.1016/j.jbusres.2015.01.040Castellano, R., Musella, G., Punzo, G.: Structure of the labour market and wage inequality: evidence from European countries. Qual. Quant. 51(5), 2191–2218 (2017)Cervelló-Royo, R., Moya-Clemente, I., Ribes-Giner, G.: Microfinance Institutions (MFIs) in Latin America: Who should finance the entrepreneurial ventures of the less privileged? In: Peris-Ortiz, M., Sahut, J.-M. (eds.) New Challenges in Entrepreneurship and Finance, pp. 235–245. Springer, Cham (2015)Cervelló-Royo, R., Guijarro, F., Martinez-Gomez, V.: Social performance considered within the global performance of Microfinance Institutions: a new approach. Oper. Res. (2017). https://doi.org/10.1007/s12351-017-0360-3Chaaban, J., Irani, A., Khoury, A.: The composite global wellbeing index (CGWBI): a new multi-dimensional measure of human development. Soc. Indic. Res. 129(1), 465–487 (2016). https://doi.org/10.1007/s11205-015-1112-5Chapple, S.: Child wellbeing and sole-parent family structure in the OECD: an analysis. OECD. Social, employment, and migration working papers (82), 0_1 (2009)Christofides, L.N., Polycarpou, A., Vrachimis, K.: Gender wage gaps, “sticky floors” and “glass ceilings” in Europe. Labour Econ. 21, 86–102 (2013). https://doi.org/10.1016/j.labeco.2013.01.003Cumming, D., Hou, W., Lee, E.: Sustainable and ethical entrepreneurship, corporate finance and governance, and institutional reform in China. J. Bus. Ethics 134(4), 505–508 (2016). https://doi.org/10.1007/s10551-014-2381-7Cummins, R.A., Eckersley, R., Pallant, J., Van Vugt, J., Misajon, R.: Developing a national index of subjective wellbeing: the Australian Unity Wellbeing Index. Soc. Indic. Res. 64(2), 159–190 (2003). https://doi.org/10.1023/A:1024704320683De la Cruz Sánchez-Escobedo, M., Díaz-Casero, J.C., Díaz-Aunión, Á.M., Hernández-Mogollón, R.: Gender analysis of entrepreneurial intentions as a function of economic development across three groups of countries. Int. Entrep. Manag. J. 10(4), 747–765 (2014). https://doi.org/10.1007/s11365-014-0314-7Diener, E.: Subjective wellbeing. In: Diener, E. (ed.) The Sicence of Wellbeing, pp. 11–58. Springer, Dordrecht (2009). https://doi.org/10.1007/978-90-481-2350-6_2Dodge, R., Daly, A., Huyton, J., Sanders, L.: The challenge of defining wellbeing. Int. J. Wellbeing 2(3), 222–235 (2012). https://doi.org/10.5502/ijw.v2i3.4Fiss, P.C.: Building better casual theories: a fuzzy set approach to typologies in organization research. Acad. Manag. J. 54(2), 393–420 (2011)Fleche, S., Smith, C., Sorsa, P.: Exploring determinants of subjective wellbeing in OECD countries (2011)Fleche, S., Smith, C., Sorsa, P.: Exploring determinants of subjective wellbeing in OECD countries evidence from the world value survey. Working papers, OECD Statistics (2012). https://doi.org/10.1787/5kg0k6zlcm5k-enFoley, A., Griffith, B.: Education, training and the promotion of high quality entrepreneurs in the Republic of Ireland. In: Scott, M.G., Rosa, P., Klandt, H. (eds.) Educating Entrepreneurs for Wealth Creation. Ashgate, Aldershot (1998)Garikipati, S.: Microcredit and women’s empowerment: through the lens of time-use data from rural India. Dev. Change 43(3), 719–750 (2012). https://doi.org/10.1111/j.1467-7660.2012.01780.xGEM (Global Entrepreneurship Monitor): Global report (2015)Harter, J.K., Schmidt, F.L., Keyes, C.L.M.: Wellbeing in the workplace and its relationship to business outcomes. A review of the Gallup studies. In: Keyes, C.L.M., Haidt, J. (eds.) Flourishing: The Positive Person and the Good Life, pp. 205–224. American Psychologi cal Association, Washington (2003)Henry, C., Foss, L., Ahl, H.: Gender and entrepreneurship research: a review of methodological approaches. Int. Small Bus. J. 34(3), 217–241 (2015). https://doi.org/10.1177/0266242614549779Hessels, J., Van Gelderen, M., Thurik, R.: Entrepreneurial aspirations, motivations, and their drivers”. Small Bus. Econ. 31(3), 323–339 (2008). https://doi.org/10.1007/s11187-008-9134-xIezzi, D.F., Deriu, F.: Women active citizenship and wellbeing: the Italian case. Qual. Quant. 48(2), 845–862 (2014)Jansson, T.: Housing choices and labor income risk. J. Urban Econ. 99, 107–119 (2017). https://doi.org/10.1016/j.jue.2016.12.006Johansen, V., Foss, L.: The effects of entrepreneurship education—does gender matter? Int. J. Entrep. Small Bus. 20(3), 255–271 (2013). https://doi.org/10.1504/IJESB.2013.056889Judge, W.Q., Hu, H.W., Gabrielsson, J., Talaulicar, T., Witt, M.A., Zattoni, A., Kibler, B.: Configurations of capacity for change in entrepreneurial threshold firms: imprinting and strategic choice perspectives. J. Manag. Stud. 52(4), 506–530 (2015). https://doi.org/10.1111/joms.12121Kautonen, T., Kibler, E., Minniti, M.: Late-career entrepreneurship, income and quality of life. J. Bus. Ventur. 32(3), 318–333 (2017). https://doi.org/10.1016/j.jbusvent.2017.02.005Kephart, P., Schumacher, L.: Has the “glass ceiling” cracked? An exploration of women entrepreneurship. J. Leadersh. Organ. Stud. 12(1), 2–15 (2005). https://doi.org/10.1177/107179190501200102Kirkwood, J.: Motivational factors in a push–pull theory of entrepreneurship. Gend. Manag. Int. J. 24(5), 346–364 (2009). https://doi.org/10.1108/17542410910968805Kobeissi, N.: Gender factors and female entrepreneurship: International evidence and policy implications. J. Int. Entrep. 8, 1–35 (2010). Retrieved from https://doi.org/10.1007/s10843-010-0045-yKuckertz, A., Berger, E.S.C., Allmendinger, M.P.: What drives entrepreneurship? A configurational analysis of the determinants of entrepreneurship in innovation-driven economies. Die Betriebswirtschaft/Bus. Adm. Rev. 75(4), 273–288 (2015). https://doi.org/10.1017/cbo9781107415324.004La Placa, V., McNaught, A., Knight, A.: Discourse on wellbeing in research and practice. Int. J. Wellbeing 3, 116–125 (2013). https://doi.org/10.5502/ijw.v3i1.7Langowitz, N., Minniti, M.: The entrepreneurial propensity of women. Entrep. Theory Pract. 31(3), 341–364 (2007). https://doi.org/10.1111/j.1540-6520.2007.00177.xLee, S.S.Y.: Examining policy configurations as conditions for long-term unemployment and non-standard employment in OECD countries using fuzzy-set analysis. Qual. Quant. 47(6), 3521–3536 (2013)Leffler, E., Svedberg, G.: Enterprise learning: a challenge to education? Eur. Educ. Res. J. 4(3), 219–227 (2005)Levie, J., Autio, E.: A theoretical grounding and test of the GEM model. Small Bus. Econ. 31(3), 235–263 (2008). https://doi.org/10.1007/s11187-008-9136-8Maccagnan, A., Wren-Lewis, S., Brown, H., Taylor, T.: Wellbeing and society: towards quantification of the co-benefits of wellbeing. Soc. Indic. Res. 1–27 (2018)Mandl, C., Berger, E.S.C., Kuckertz, A.: Do you plead guilty? Exploring entrepreneurs’ sensemaking-behavior link after business failure. J. Bus. Ventur. Insights 5, 9–13 (2016). https://doi.org/10.1016/j.jbvi.2015.12.002Martin, B.C., McNally, J.J., Kay, M.J.: Examining the formation of human capital in entrepreneurship: a meta-analysis of entrepreneurship education outcomes. J. Bus. Ventur. 28(2), 211–224 (2013). https://doi.org/10.1016/j.jbusvent.2012.03.002McClelland, E., Swail, J., Bell, J., Ibbotson, P.: Following the pathway of female entrepreneurs. Int. J. Entrep. Behav. Res. 11(2), 84–107 (2005). https://doi.org/10.1108/13552550510590527Millán, J.M., Hessels, J., Thurik, R., Aguado, R.: Determinants of job satisfaction: a European comparison of self-employed and paid employees. Small Bus. Econ. 40(3), 651–670 (2013). https://doi.org/10.1007/s11187-011-9380-1Minniti, M., Nardone, C.: Being in someone else’s shoes: the role of gender in nascent entrepreneurship. Small Bus. Econ. 28(2–3), 223–238 (2007). https://doi.org/10.1007/s11187-006-9017-yMishra, V., Nielsen, I., Smyth, R.: How does relative income and variations in short-run wellbeing affect wellbeing in the long run? Empirical evidence from China’s Korean minority. Soc. Indic. Res. 115(1), 67–91 (2014)Murias, P., Martinez, F., de Miguel, C.: An economic wellbeing index for the Spanish provinces: a data envelopment analysis approach. Soc. Indic. Res. 77(3), 395–417 (2006). https://doi.org/10.1007/s11205-005-2613-4Naudé, W., Amorós, J.E., Cisti, O.: Surfeiting, the appetite may sticken: entrepreneurship and happiness. Small Bus. Econ. 42(3), 523–540 (2014)Ng, T.W.H., Feldman, D.C.: Re-examining the relationship between age and voluntary turnover. J. Vocat. Behav. 74(3), 283–294 (2009). https://doi.org/10.1016/j.jvb.2009.01.004O’Connor, A.: A conceptual framework for entrepreneurship education policy: meeting government and economic purposes. J. Bus. Ventur. 28(4), 546–563 (2013). https://doi.org/10.1016/j.jbusvent.2012.07.003Organisation for Economic Co-operation and Development (OECD): OECD guidelines on measuring subjective well-being (2013)Organization for Economic Cooperation and Development: How’s Life? Measuring Wellbeing (2015). http://www.oecdbetterlifeindex.org . Accessed 28 May 2017Orlova, L.V., Sakhabieva, G.A., Vasyaycheva, V.A., Pronina, N.N.: Impact of educational attainment on the development of female entrepreneurship in Kazakhstan. Indian J. Sci. Technol. (2016). https://doi.org/10.17485/ijst/2016/v9i11/89427Osberg, L., Sharpe, A.: An index of economic wellbeing for selected OECD countries. Rev. Income Wealth 5(3), 291–316 (2002). https://doi.org/10.1111/1475-4991.00056Osberg, L., Sharpe, A.: New Estimates of the Index of Economic Wellbeing for Selected OECD Countries, 1980–2007. Centre for the Study of Living Standards, Ottawa (2009)Parasuraman, S., Purohit, Y.S., Godshalk, V.M., Beutell, N.J.: Work and family variables, entrepreneurial career success, and psychological wellbeing. J. Vocat. Behav. 48(3), 275–300 (1996). https://doi.org/10.1006/jvbe.1996.0025Parasuraman, S., & Simmers, C.A.: Type of employment, work–family conflict and well-being: a comparative study. J. Organ. Behav.: Int. J Ind., Occup. Organ. Psychol. Behav. 22(5), 551–568 (2001)Patrick, C., Stephens, H., Weinstein, A.: Where are all the self-employed women? Push and pull factors influencing female labor market decisions. Small Bus. Econ. 46(3), 365–390 (2016). https://doi.org/10.1007/s11187-015-9697-2Poggesi, S., Mari, M., De Vita, L.: What’s new in female entrepreneurship research? Answers from the literature. Int. Entrep. Manag. J. 12(3), 735–764 (2015). https://doi.org/10.1007/s11365-015-0364-5Ragin, C.: The Comparative Method: Moving Beyond Qualitative and Quantitative Strategies. University of California Press, Berkeley (1987)Ragin, C.C.: New directions in comparative research. In: Kohn, M.L. (ed.) Cross-National Research in Sociology, pp. 57–76. Sage, Newbury Park (1989)Ragin, C.C.: Fuzzy-Set Social Science. University of Chicago Press, Chicago (2000)Ragin, Charles C., Sonnett, J.: Between complexity and parsimony: limited diversity, counterfactual cases, and comparative analysis. In: Ragin, Charles C. (ed.) Redesigning Social Inquiry. University of Chicago Press, Chicago (2004)Ragin, C.C.: Redesigning Social Inquiry: Fuzzy Sets and Beyond, vol. 240. University of Chicago Pres, Chicago (2008)Rahman, S.A., Amran, A., Ahmad, N.H., Taghizadeh, S.K.: Enhancing the wellbeing of base of the pyramid entrepreneurs through business success: the role of private organizations. Soc. Indic. Res. 127(1), 195–216 (2016). https://doi.org/10.1007/s11205-015-0951-4Renee Baptiste, N.: Tightening the link between employee wellbeing at work and performance. Manag. Decis. 46(2), 284–309 (2008). https://doi.org/10.1108/00251740810854168Rey-Martí, A., Tur Porcar, A., Mas-Tur, A.: Linking female entrepreneurs’ motivation to business survival. J. Bus. Res. 68(4), 810–814 (2015). https://doi.org/10.1016/j.jbusres.2014.11.033Reynolds, P.D., Bygrave, W.D., Autio, E., Cox, L.W., Hay, M.: Global entrepreneurship monitor, 2002 executive report. London (2002)Ribes-Giner, G., Moya-Clemente, I., Cervelló-Royo, R., Perello-Marin, M.R.: Domestic economic and social conditions empowering female entrepreneurship. J. Bus. Res. 89, 182–189 (2018)Ruth Eikhof, D., Summers, J., Carter, S., Eikhof, D.R., Summers, J., Carter, S.: Women doing their own thing: media representations of female entrepreneurship. Int. J. Entrep. Behav. Res. 19(5), 547–564 (2013). https://doi.org/10.1108/IJEBR-09-2011-0107Sampedro Gallego, R., Camarero Rioja, L.: Female entrepreneurs in rural Spain—the failed subject of development. Rev. Int. Sociol. 65(48), 121–146 (2007)Saridakis, G., Marlow, S., Storey, D.J.: Do different factors explain male and female self-employment rates? J. Bus. Ventur. 29(3), 345–362 (2014). https://doi.org/10.1016/j.jbusvent.2013.04.004Shepherd, D.A., Douglas, E.J., Shanley, M.: New venture survival: ignorance, external shocks, and risk reduction strategies. J. Bus. Ventur. 15(5), 393–410 (2000). https://doi.org/10.1016/S0883-9026(98)00008-1Shepherd, D., Haynie, J.M.: Birds of a feather don’t always flock together: identity management in entrepreneurship. J. Bus. Ventur. 24(4), 316–337 (2009). https://doi.org/10.1016/j.jbusvent.2007.10.005Shinnar, R.S., Hsu, D.K., Powell, B.C.: Self-efficacy, entrepreneurial intentions, and gender: assessing the impact of entrepreneurship education longitudinally. Int. J. Manag. Educ. 12(3), 561–570 (2014). https://doi.org/10.1016/j.ijme.2014.09.005Shir, N.: Entrepreneurial Wellbeing: The Payoff Structure of Business Creation. Stockholm School of Economics, Stockholm (2015)Thiem, A., Dusa, A.: QCA: a package for qualitative comparative analysis. R package version 2.0. R J. 5, 87–97 (2013). Retrieved from https://cran.r-project.org/web/packages/QCA/index.htmlTorri, M.M.C., Martinez, A.: Women’s empowerment and micro-entrepreneurship in India: constructing a new development paradigm? Prog. Dev. Stud. 14(1), 31–48 (2014). https://doi.org/10.1177/1464993413504347Tur-Porcar, A., Mas-Tur, A., Belso, J.A.: Barriers to women entrepreneurship. Different methods, different results? Qual. Quant. 51(5), 2019–2034 (2017)Uy, M.A., Foo, M.Der, Song, Z.: Joint effects of prior start-up experience and coping strategies on entrepreneurs’ psychological wellbeing. J. Bus. Ventur. 28(5), 583–597 (2013). https://doi.org/10.1016/j.jbusvent.2012.04.003Uy, M.A., Sun, S., Foo, M.Der: Affect spin, entrepreneurs’ wellbeing, and venture goal progress: the moderating role of goal orientation. J. Bus. Ventur. 32(4), 443–460 (2017). https://doi.org/10.1016/j.jbusvent.2016.12.001Van der Sluis, J., Van Praag, M., Vijverberg, W.: Education and entrepreneurship selection and performance: a review of empirical literature. J. Econ. Surv. 22(5), 795–841 (2008)Verheul, I., Stel, A.Van, Thurik, R.: Explaining female and male entrepreneurship at the country level. Entrep. Reg. Dev. 18(2), 151–183 (2006). https://doi.org/10.1080/08985620500532053Witbooi, M., Ukpere, W.: Indigenous female entrepreneurship: analytical study on access to finance for women entrepreneurs in South Africa. Afr. J. Bus. Manag. 5(14), 5646–5657 (2011)Woodside, A.G., Bernal, P.M., Coduras, A.: The general theory of culture, entrepreneurship, innovation, and quality-of-life: comparing nurturing versus thwarting enterprise start-ups in BRIC, Denmark, Germany, and the United States. Ind. Mark. Manag. (2015). https://doi.org/10.1016/j.indmarman.2015.11.00

Decision Support System for the Response to Infectious Disease Emergencies Based on WebGIS and Mobile Services in China

Background: For years, emerging infectious diseases have appeared worldwide and threatened the health of people. The emergence and spread of an infectious-disease outbreak are usually unforeseen, and have the features of suddenness and uncertainty. Timely understanding of basic information in the field, and the collection and analysis of epidemiological information, is helpful in making rapid decisions and responding to an infectious-disease emergency. Therefore, it is necessary to have an unobstructed channel and convenient tool for the collection and analysis of epidemiologic information in the field. Methodology/Principal Findings: Baseline information for each county in mainland China was collected and a database was established by geo-coding information on a digital map of county boundaries throughout the country. Google Maps was used to display geographic information and to conduct calculations related to maps, and the 3G wireless network was used to transmit information collected in the field to the server. This study established a decision support system for the response to infectious-disease emergencies based on WebGIS and mobile services (DSSRIDE). The DSSRIDE provides functions including data collection, communication and analyses in real time, epidemiological detection, the provision of customized epidemiological questionnaires and guides for handling infectious disease emergencies, and the querying of professional knowledge in the field. These functions of the DSSRIDE could be helpful for epidemiological investigations in the field and the handling of infectious-disease emergencies. Conclusions/Significance: The DSSRIDE provides a geographic information platform based on the Google Maps application programming interface to display information of infectious disease emergencies, and transfers information between workers in the field and decision makers through wireless transmission based on personal computers, mobile phones and personal digital assistants. After a 2-year practice and application in infectious disease emergencies, the DSSRIDE is becoming a useful platform and is a useful tool for investigations in the field carried out by response sections and individuals. The system is suitable for use in developing countries and low-income districts

Oxidative Stress and Inflammation in Renal Patients and Healthy Subjects

The first goal of this study was to measure the oxidative stress (OS) and relate it to lipoprotein variables in 35 renal patients before dialysis (CKD), 37 on hemodialysis (HD) and 63 healthy subjects. The method for OS was based on the ratio of cholesteryl esters (CE) containing C18/C16 fatty acids (R2) measured by gas chromatography (GC) which is a simple, direct, rapid and reliable procedure. The second goal was to investigate and identify a triacylglycerol peak on GC, referred to as TG48 (48 represents the sum of the three fatty acids carbon chain lengths) which was markedly increased in renal patients compared to healthy controls. We measured TG48 in patients and controls. Mass spectrometry (MS) and MS twice in tandem were used to analyze the fatty acid composition of TG48. MS showed that TG48 was abundant in saturated fatty acids (SFAs) that were known for their pro-inflammatory property. TG48 was significantly and inversely correlated with OS. Renal patients were characterized by higher OS and inflammation than healthy subjects. Inflammation correlated strongly with TG, VLDL-cholesterol, apolipoprotein (apo) C-III and apoC-III bound to apoB-containing lipoproteins, but not with either total cholesterol or LDL-cholesterol