3 research outputs found
Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2)
- Author
- A Dive
- Ahmed El Kalioubie
- Ali Ait Hssain
- Amélie Le Gouge
- Anne Bretagnol
- AR Blaser
- AW Bradbury
- B De Jonghe
- Benoit Misset
- Bertrand Guidet
- Bruno Giraudeau
- C Alberda
- C Favier
- Carole Schwebel
- CB Kölbel
- Christophe Guitton
- CL Braunschweig
- CP Heidegger
- D Heyland
- Daniel Silva
- Didier Thévenin
- DK Heyland
- DK Heyland
- Emilie Gréau
- Emmanuel Canet
- Emmanuelle Mercier
- Erika Parmentier
- F Simpson
- FA Moore
- Ferhat Meziani
- Frédéric Bellec
- Frédéric Martino
- Frédérique Ganster
- G Elke
- Gael Piton
- GS Doig
- GS Doig
- H Mentec
- H Stöckmann
- H Yasuhara
- Hervé Dupont
- Hoang-Nam Bui
- I de Beaux
- I Khalid
- IG Schoots
- J Chastre
- J Landzinski
- J Reignier
- J Reignier
- J Reignier
- J Savović
- Jack Richecoeur
- JC Montejo
- Jean Etienne Herbrecht
- Jean Reignier
- Jean-Baptiste Lascarrou
- Jean-Paul Mira
- Jean-Philippe Rigaud
- Jean-Pierre Quenot
- JL Vincent
- JM Binnekade
- JM Binnekade
- JP Quenot
- JR Le Gall
- JR Tsai
- JV Peter
- Jérôme Devaquet
- K Bosscha
- Karim Asehnoune
- KD Röhm
- KG Kreymann
- L Bortenschlager
- L Gianotti
- L Gramlich
- Laurent Brisard
- M Braga
- M Gatt
- M Schuster-Bruce
- M Thuong
- MA Ritz
- Mercé Jourdain
- Michael Darmon
- Michel Djibre
- Michel Sirodot
- MJ Chapman
- MP Casaer
- MP Casaer
- Nadia Anguel
- Nathalie Rolin
- NE Cahill
- Olivier Gontier
- PE Marik
- PE Marik
- Philippe Letocart
- Pierre Asfar
- PJM Weijs
- R Beier-Holgersen
- R Peto
- R Pettignano
- R Rokyta Jr
- R Thibault
- RD Hubmayr
- René Robert
- RJ Hadfield
- S Adam
- S van Schijndel RJM
- S Villet
- SA McClave
- SA McClave
- SA McClave
- Saad Nseir
- Stéphane Gaudry
- Stéphanie Martin
- SV Desai
- TR Ziegler
- V Artinian
- Vincent Das
- Virginie Maxime
- Vlad Botoc
- Véronique Leray
- WA Oldenburg
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
BACKGROUND: Nutritional support is crucial to the management of patients receiving invasive mechanical ventilation (IMV) and the most commonly prescribed treatment in intensive care units (ICUs). International guidelines consistently indicate that enteral nutrition (EN) should be preferred over parenteral nutrition (PN) whenever possible and started as early as possible. However, no adequately designed study has evaluated whether a specific nutritional modality is associated with decreased mortality. The primary goal of this trial is to assess the hypothesis that early first-line EN, as compared to early first-line PN, decreases day 28 all-cause mortality in patients receiving IMV and vasoactive drugs for shock. METHODS/DESIGN: The NUTRIREA-2 study is a multicenter, open-label, parallel-group, randomized controlled trial comparing early PN versus early EN in critically ill patients requiring IMV for an expected duration of at least 48 hours, combined with vasoactive drugs, for shock. Patients will be allocated at random to first-line PN for at least 72 hours or to first-line EN. In both groups, nutritional support will be started within 24 hours after IMV initiation. Calorie targets will be 20 to 25 kcal/kg/day during the first week, then 25 to 30 kcal/kg/day thereafter. Patients receiving PN may be switched to EN after at least 72 hours in the event of shock resolution (no vasoactive drugs for 24 consecutive hours and arterial lactic acid level below 2 mmol/L). On day 7, all patients receiving PN and having no contraindications to EN will be switched to EN. In both groups, supplemental PN may be added to EN after day 7 in patients with persistent intolerance to EN and inadequate calorie intake. We plan to recruit 2,854 patients at 44 participating ICUs. DISCUSSION: The NUTRIREA-2 study is the first large randomized controlled trial designed to assess the hypothesis that early EN improves survival compared to early PN in ICU patients. Enrollment started on 22 March 2013 and is expected to end in November 2015. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01802099 (registered 27 February 2013)
New Insights into Modulation of Thrombin Formation
- Author
- A Brill
- A Girolami
- A Kubier
- AJ Martí-Carvajal
- AR Rezaie
- B Engelmann
- B Furie
- B Weijs
- C Kannemeier
- CB Glaser
- CP Vicente
- CT Ammollo
- CT Esmon
- CT Esmon
- D Blomstrand
- D Gailani
- DA Lane
- DR Fabri
- E Zorio
- EM Conway
- F Bea
- F Nakazawa
- F Semeraro
- FJ Castellino
- FK Swirski
- GYH Lip
- H Cate ten
- H Cate Ten
- H Ishii
- H Ishii
- H Weiler
- Henri M.H. Spronk
- HH Versteeg
- Hugo ten Cate
- I-O Lee
- J Emsley
- J Khallou-Laschet
- JI Borissoff
- JI Borissoff
- JI Borissoff
- JI Borissoff
- JI Borissoff
- JI Borissoff
- JN Wilcox
- JTB Crawley
- Julian I. Borissoff
- K Matsumoto
- L Zitvogel
- M Colucci
- M Levi
- M Levi
- M Levi
- M Nesheim
- M Zarrouk
- M-L Brühl von
- ML Kahn
- ML Montfoort van
- N Grimsey
- N Mackman
- NPE Kadoglou
- P Libby
- PH Reitsma
- PL Giesen
- Q Zhou
- R Loeffen
- R Ross
- R Virmani
- RA Schuepbach
- RJ Westrick
- RJMW Rennenberg
- S Fischer
- S Jain
- S Massberg
- S Oehmcke
- S Seehaus
- SF Meyer De
- SJ Webster
- SN Faust
- SR Lentz
- T Kölbel
- T Osaki
- T Renné
- TA Fuchs
- TM Hackeng
- V Bauer
- V Brinkmann
- Y Ikari
- Z Ye
- ZG Laszik
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Viskosität
- Author
- A Artemcenko
- A Baader
- A Bak
- A Banchettr
- A Banchettr
- A Bartoli
- A Bartoli
- A Bearden
- A Bestelmeyer
- A Bestelmeyer
- A Bienas
- A Bienas
- A Bock de
- A Boek
- A Bramley
- A Broese Groeneu van
- A Camerton
- A Campetti
- A Crozier
- A Dietzel
- A Einstein
- A Einstein
- A Emmerich
- A Findlay
- A Fortier
- A Fortier
- A Gille
- A Gorke
- A Heydweiller
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Jaumotte
- A Jaumotte
- A Jobling
- A Jobling
- A Kanitz
- A Klemenc
- A Knappworst
- A Knappworst
- A Kolossowski
- A Korosi
- A Kryagowa
- A Kundt
- A Königer
- A Leontyewa
- A Maman
- A Michels
- A Michels
- A Michels
- A Michels
- A Napolitano
- A Naumowa
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- A Pochettino
- A Röder
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- M Laue
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- M Mooney
- M Nadi
- M Plüss
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- M Prod’homme
- M Reinganum
- M Rigby
- M Scanavy-Grigoriewa
- M Shimotaki
- M Shimotaki
- M Solomon
- M Souders
- M Stuckgold
- M Sul’gina
- M Tamura
- M Thiesen
- M Trautz
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- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Trautz
- M Wildhagen
- M Wogau
- M Yasuda
- M Čepeleweckiῐ
- MA Graham
- MA Kločko
- MA Kločko
- MA Opykhtina
- MA Weksler
- MC Brinkman
- MC Fontaine-Limbourg
- MD Beludew
- MF Culpin
- MG Frohberg
- MG Frohberg
- MG Frohberg
- MG Gonikberg
- MG Gonikberg
- MH Gonzales
- MH Gonzalez
- MH Gonzalez
- MH Gonzalez
- MI Usanowiö
- MI Usanowiö
- MI Usanowiö
- MJ Kenney
- MJ Kenney
- MJ Rice
- MK Phibbs
- ML Anderson
- ML Miller
- ML Rawič
- ML Sheely
- ML Usanowiö
- ML Usanowiö
- ML Usanowiö
- MM Karawayew
- MM Lerer
- MM Wetyukow
- MN States
- MP Applebey
- MP Volarovich
- MP Vukalovitch
- MP Wolarowic
- MR Cannon
- MR Cannon
- MR Cannon
- MR Hopkins
- MR Lipkin
- MR Nayar
- MR Nayar
- MS Lyons
- MS Rudenko
- MT Rogers
- MV Dover
- MW Okhotin
- MW Smirnow
- N Efremow
- N Efremow
- N Eyring
- N Eyring
- NA Agaew
- NA Agayew
- NA Agayew
- NA Grundberg
- NA Kalakuckaya
- NA Lemaire
- NA Puschin
- NA Salberow
- NA Yajnik
- NA Yajnik
- ND Litwinow
- NE Dorsey
- NE Dorsey
- NE Gnezdilow
- NE Menabde
- NE Wassenko
- NF Bright
- NF Shdanowa
- NG Forster
- NG Forster
- NG Čownyk
- NH Harlshorne
- NI Kopylow
- NI Wrzosek
- NJ Trappeniers
- NL Carr
- NL Carr
- NL Carr
- NL Dykcenko
- NM Baron
- NM Bokarewa
- NMP Madan
- NN Greenwood
- NN Greenwood
- NN Koledow
- NN Ruban
- NP Doss
- NP Isakowa
- NP Tsanukwadze
- NS Bubyrewa
- NS Fortunatow
- NS Kurnakow
- NS Kurnakow
- NS Kurnakow
- NS Kurnakow
- NS Rudenko
- NS Rudenko
- NS Rudenko
- NS Rudenko
- NS Rudenko
- NS Rudenko
- NS Rudenko
- NV Sidgwick
- NW Bondarenko
- NW Bondarenko
- NW Krase
- NW Pawlowic
- NW Solomin
- O Albert
- O Faust
- O Faust
- O Faust
- O Faust
- O Faust
- O Faust
- O Faust
- O Halpern
- O Halpern
- O Halpern
- O Köhler
- O Maas
- O Maass
- O Miller
- O Pulvermacher
- O Reynolds
- O Reynolds
- O Ruff
- O Scarpa
- O Scarpa
- O Scheur
- O Spengler
- O Zimmer
- OA Osipow
- OE Frivold
- OE Meyer
- OF Tower
- OL Hughes
- OL Leipunskii
- OLL Brown
- ON Schokina
- OW Edwards
- OW Howell
- P Assarsson
- P Bidde
- P Breitenbach
- P Breitenbach
- P Brémont
- P Dutoit
- P Dutoit
- P Gilard
- P Gilard
- P Goldberg
- P Günther
- P Harteck
- P Karrer
- P Lereux
- P Lutschinsky
- P Macedo
- P Maine
- P Oakley
- P Phillips
- P Phillips
- P Prasad
- P Prasad
- P Reschke
- P Tänzler
- P Waiden
- P Waiden
- P Waiden
- P Waiden
- P Waiden
- P Waiden
- P Waiden
- P Waiden
- P Wulff
- PA Levene
- PA Rubero
- PA Zawarikina
- PB Das
- PB Das
- PB Das
- PB Das
- PB Das
- PB Das
- PB Davis
- PB Davis
- PB Davis
- PB Ganguly
- PE Li
- PE Liley
- PE Parisot
- PG Gilchrist
- PG Sears
- PI Procenko
- PI Sanin
- PJ Achener
- PJ Carlisle
- PJ Dunlop
- PJ Dunlop
- PJ Rohlin
- PK Chakraborti
- PK Katti
- PK Migal
- PL Sanin
- PM Chaudhuri
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- PM Kampmeyer
- PM Strocchi
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- PM Strocchi
- PM Strocchi
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- PW Bridgman
- PW Selwood
- PY Siwer
- R Anderson
- R Arpi
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- R Bulkley
- R Cohen
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- R Fanelli
- R Fanelli
- R Fanelli
- R Fricke
- R Führth
- R Gartenmeister
- R Gartenmeister
- R Heinze
- R Hosking
- R Höppler
- R Kalidas
- R Kay
- R Kiyama
- R Kremann
- R Kremann
- R Ladenburg
- R Linke
- R Lorentz
- R Lorenz
- R Meyer
- R Pippo
- R Plank
- R Plank
- R Riemschneider
- R Roscoe
- R Rossin
- R Schmidt
- R Schumann
- R Springer
- R Suhrman
- R Suhrmann
- R Suleimanow
- R Thacker
- R Wobser
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- RA Eppler
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- RH Ewell
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- Rietveld
- RJ Donnelly
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- RJ Fort
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- RK Ber Le
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- RL Olson
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- RM Melaven
- RN Barfield
- RN Barfield
- RN Hopkins
- RP Airapetowa
- RP Généreaux
- RP Gênereaux
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- RP Shukla
- RS Dantuma
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- RS Porter
- RT Ahlert
- RV Helm
- RV Theiss
- RW Gallant
- RW Haywood
- RW Moulton
- RW Schiessler
- RW Schiessler
- RWH Webeler
- S Alamelu
- S Alamelu
- S Arrhenius
- S Brunet
- S Chella
- S Erk
- S Erk
- S Erk
- S Erk
- S Erk
- S Förster
- S Karpacew
- S Kikuhi
- S Koch
- S Koch
- S Kyropoulus
- S Landa
- S Lengyel
- S Makishima
- S Mallikarjun
- S Mathur
- S Mitzukuri
- S Mizushima
- S Pagliani
- S Peter
- S Ray
- S Sheppard
- S Sheppard
- S Weissman
- S Zämirea
- SA Mumford
- SA Woznesenskiῐ
- SC Barnett
- SC Mason
- SD Baron
- SD Gromakow
- SE Babb
- SE Bressler
- SF Babak
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- SF Gerf
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- ST Bowden
- ST Dobinski
- ST Dobinski
- SW Holman
- SW Kriwokhiza
- SW Sergeew
- SZ Mikhaü
- SZ Štamowa
- T Doi
- T Doi
- T Doi
- T Erdey-Grùz
- T Erdey-Grùz
- T Graham
- T Graham
- T Graham
- T Graham
- T Graham
- T Ishikawa
- T Kihara
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- T Kurucsev
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- T Makita
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- T Makita
- T Mukoyama
- T Naiki
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- T Titani
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- T Titani
- T Titani
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- T Tonomura
- T Tonomura
- TC Toye
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- TW Selby
- TW Yao
- TW Yao
- TY Ju
- V Crescenti
- V Desreux
- V Griffing
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- V Lantz
- V Vand
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- VC Reinsborough
- VCG Trew
- VD Majumdar
- VE Denny
- VK Venkatesan
- VM Heston
- VR Main
- VR Stott
- VV Chandramouli
- W Bambynek
- W Bambynek
- W Geiseler
- W Groth
- W Herz
- W Herz
- W Herz
- W Herz
- W Herz
- W Herz
- W Herz
- W Koenig
- W Konstantinow
- W Kopsch
- W Krings
- W Licht
- W Lohse
- W Mazer
- W Meissner
- W Menz
- W Morrison-Jackson
- W Ostwald
- W Petrow
- W Pleskow
- W Plotnikow
- W Radecker
- W Riemann
- W Ruckes
- W Schiller
- W Schudel
- W Schugayew
- W Sutherland
- W Tchugayew
- W Weber
- WA Everhart
- WA Granzun
- WA Hare
- WA Hawksworth
- WA Kireew
- WA Pardee
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- WB Falkowski
- WC McCaughey
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- WE Grant
- WE Keller
- WE Keller
- WF Barber
- WF Darke
- WF Giauque
- WF Giauque
- WF Schottky
- WF Seyer
- WG Komarenko
- WG Parks
- WG Shilling
- WH Carothers
- WH Gibson
- WH Harcher
- WH Keesom
- WH Keeson
- WH Mears
- WH Rinkenbach
- WI Semisin
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- WJ Fisher
- WJ Fisher
- WJ Fisher
- WJ Fisher
- WJ Heikkilla
- WJ Jones
- WJ Thomas
- WJ Wallace
- WK Semencenko
- WL Robb
- WL Sibbit
- WL Zyazew
- WM Bleakney
- WM Cox
- WM Hartford
- WM Jackson
- WN Baker
- WN Baker
- WN Bond
- WN Bond
- WN Cox
- WP Barzakowski
- WP Masowec
- WR Bousfield
- WR Bousfield
- WR Kelly
- WR Wijk
- WRD Jones
- WS Barnhart
- WS Galinker
- WS Galinker
- WS Groenier
- WS Schugayew
- WS Schugayew
- WT Foley
- WT Slawyanskiῐ
- WT Slawyanskiῐ
- WT Sumarokow
- WV Houston
- WW Pigulewskii
- WW Stender
- WW Steward
- WW Taylor
- WW Udowenko
- WW Udowenko
- WW Udowenko
- WW Udowenko
- WY Anosow
- Y Bjornståhl
- Y Delcourt
- Y Ishida
- Y Kozlow
- Y Nakagawa
- Y Sing
- Y Suga
- YA Fialkow
- YAL Dutcak
- YAL Dutcak
- YAL Dutcak
- YC Wu
- YM Ping
- YP Gokhstein
- YP Gokhstein
- YS Chiong
- YS Chiong
- YY Fialkow
- YY Fialkow
- YY Fialkow
- YY Fialkow
- YY Fialkow
- YY Fialkow
- Z Friedländer
- Z Golik
- Z Golik
- Z Reyer
- ZW Kondratenko
- ZW Wolkowa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study