Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences

Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease control. Current molecular tests examine limited numbers of mutations, and although whole genome sequencing approaches could fully characterise DR, data complexity has restricted their clinical application. A library (1,325 mutations) predictive of DR for 15 anti-tuberculosis drugs was compiled and validated for 11 of them using genomic-phenotypic data from 792 strains. A rapid online ‘TB-Profiler’ tool was developed to report DR and strain-type profiles directly from raw sequences. Using our DR mutation library, in silico diagnostic accuracy was superior to some commercial diagnostics and alternative databases. The library will facilitate sequence-based drug-susceptibility testing

Tesla: the life and times of an electric messiah

Despite being incredibly popular during his time, Nikola Tesla today remains largely overlooked among lists of the greatest inventors and scientists of the modern era.  Thomas Edison gets all the glory for discovering the light bulb, but it was his one time assistant and life long arch nemesis, Tesla, who made the breakthrough in alternating current technology.  Edison and Tesla carried on a bitter feud for years, but it was Tesla's AC generators that illuminated the 1893 World's Fair in Chicago; the first time that an event of such magnitude had ever taken place under artificial light.  Today, all homes and electrical appliances run on Tesla's AC current.Born in Croatia in 1856, Tesla spoke eight languages and as well as almost single handedly developing household electricity.  During his life, he patented more than 700 inventions.  He invented electrical generators, FM radio, remote control robots, spark plugs and fluorescent lights.  He had a photographic memory and did advanced calculus and physics equations in his head.Of course, like many other eccentric geniuses, Tesla was completely insane.  He was prone to nervous breakdowns, claimed to receive weird visions in the middle of the night, spoke to pigeons, and occasionally thought he was receiving electromagnetic signals from extra terrestrials on Mars.  He was an obsessive compulsive hating round objects and anything that wasn't divisible by the number three.  Nikola Tesla was the ultimate mad scientist

Rahasia Kehidupan Seks Para Paus. : Sex lives of the Popes.

Yogyakartaxii, 284 p, 24 cm

Rahasia kehidupan seks para paus= Sebuah ekspos yang sangat berani tentang uskup-uskup roma dari Santo Petrus sampai sekarang

Bibliografi hlm. 275-277xii, 284 hlm.; 25 cm

KERJA PARA INSINYUR: PESAWAT TERBANG PENUMPANG

30 hlm; illus;22 x 29 c

100 Bencana Yang Mengguncang Dunia (100 disasters that shook the world)

Judul Asli : 100 Disasters that shook the world237 p. : il.; 25 cm