Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML

HTIF1α, a transcription coactivator which is able to mediate RARα activity and functionally interact with PML, is encoded by a gene on chromosome 7q32–34, which is a critical region in acute myeloid leukemias (AML). With the assumption that this gene may be related to AML, we investigated the HTIF1α DNA structure and RNA expression in leukemic cells from 36 M1–M5 AML patients (28 ‘de novo’ and eight ‘secondary’ to myelodysplastic syndrome (MDS)). Abnormal HTIF1α DNA fragments were never found, whereas loss of HTIF1α DNA was observed in the patients with chromosome 7q32 deletion and translocation, and in one case without detectable chromosome 7 abnormality. HTIF1α RNA was found in acute myelocytic leukemic blasts, and was almost undetectable in normal mononuclear cells. The expression varied among the patients: higher in M1 to M3 subtypes, with the highest values in M1; low levels were constantly observed in M4 and M5 AML. In addition, HTIF1α was significantly overexpressed in MDS-related AML (MDR-AML), but not in MDS. We also found that HTIF1α expression was high in myeloid cell lines. In myeloblastic HL60 and promyelocytic NB4 cells, induced to differentiate along the monocytic–macrophage pathway by TPA or vitamin D3, HTIF1α expression decreased, whereas it was maintained at high levels on induction to granulocytic differentiation by RA or DMSO. In K562 cells, HTIF1α RNA levels did not change after hemin-induced erythroid differentiation. These results suggest that HTIF1α could play a role in myeloid differentiation, being distinctly regulated in hematopoietic lineages

Cutaneous T-cell lymphomas

Review on Cutaneous T-cell lymphomas, with data on clinics, and the genes involved

Small lymphocytic lymphoma

Review on Small lymphocytic lymphoma, with data on clinics, and the genes involved

Diffuse large cell lymphoma

Review on Diffuse large cell lymphoma, with data on clinics, and the genes involved

Primary cutaneous CD30+ anaplastic large cell lymphoma

Review on Primary cutaneous CD30+ anaplastic large cell lymphoma, with data on clinics, and the genes involved

Adult T-cell leukemia/lymphoma (ATLL)

Review on Adult T-cell leukemia/lymphoma (ATLL), with data on clinics, and the genes involved

Mycosis fungoides/Sezary's syndrome

Review on Mycosis fungoides/Sezary's syndrome, with data on clinics, and the genes involved

Lymphoplasmacytic lymphoma

Review on Lymphoplasmacytic lymphoma, with data on clinics, and the genes involved

First Measurement of Hypernuclei and Antihypernuclei at the LHC

In this Letter, the first evidence of the (Formula presented) antihypernucleus is presented, along with the first measurement at the LHC of the production of (anti)hypernuclei with mass number (Formula presented), specifically (Formula presented) and (Formula presented). In addition, the antiparticle-to-particle ratios for both hypernuclei ((Formula presented) and (Formula presented)) are shown, which are sensitive to the baryochemical potential of the strongly interacting matter created in heavy-ion collisions. The results are obtained from a data sample of central Pb-Pb collisions, collected during the 2018 LHC data taking at a center-of-mass energy per nucleon pair of (Formula presented). The yields measured for the average of the charge-conjugated states are found to be (Formula presented) for the (Formula presented) and (Formula presented) for the (Formula presented), and the measured antiparticle-to-particle ratios are in agreement with unity. The presence of (Formula presented) and (Formula presented) excited states is expected to strongly enhance the production yield of these hypernuclei. The yield values exhibit a combined deviation of (Formula presented) from the theoretical ground-state-only expectation, while the inclusion of the excited states in the calculations leads to an agreement within (Formula presented) with the present measurements. Additionally, the measured (Formula presented) and (Formula presented) masses are compatible with the world-average values within the uncertainties