Review on Cutaneous T-cell lymphomas, with data on clinics, and the genes involved

Castoldi, GL

Cuneo, A

Atlas of Genetics and Cytogenetics in Oncology and Haematology

I-Revues

   
 
 
 
 
 
Leukaemia Section 
Short Communication 
 
Atlas Genet Cytogenet Oncol Haematol. 2005; 9(3)  
 
241 
Atlas of Genetics and Cytogenetics 
in Oncology and Haematology 
OPEN ACCESS JOURNAL AT INIST-CNRS 
Cutaneous T-cell lymphomas 
Antonio Cuneo, Gianluigi Castoldi 
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, 
Ferrara, Italy (AC, GLC) 
 
Published in Atlas Database: May 2005 
Online updated version: http://AtlasGeneticsOncology.org/Anomalies/CutanTcellID2035.html 
DOI: 10.4267/2042/38217 
 
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. 
© 2005 Atlas of Genetics and Cytogenetics in Oncology and Haematology 
 
Clinics and pathology 
Phenotype/cell stem origin 
These are peripheral T-cell tumours, usually expressing 
CD4 along with other T-cell markers. The CD30 
molecule is expressed in a histologically distinct subset 
(vide infra). 
Classification: The WHO identifies some well-defined 
clinicopathological entities with distinct clinical 
behaviour. Indolent forms include mycosis fungoides, 
primary cutaneous CD30 (Ki1) positive anaplastic large 
cell lymphomas and its benign variant lymphomatous 
papulosis; aggressive forms include Sezary's syndrome 
and peripheral CD30-negative T-cell lymphoma. 
Epidemiology 
Primary cutaneous non Hodgkin's lymphomas (NHL) 
has an approximate 0,4/100.000 incidence in  
the U.S. The majority of patients are between 40 and 60 
years old. 
Clinics 
Details on clinics, pathology, cytogenetics and 
molecular cytogenetics can be found in disease-specific 
cards (i.e. mycosis fungoides / Sezary's syndrome, 
primary cutaneous CD30 positive anaplastic large cell 
lymphoma). 
References 
Connors JM, His E, Foss F. Lymphoma of the skin. ASH 
Educational book, pp. 1926. 
Wilson LD, Jones G, Kacinski B, Edelson R, Heald P. 
Cutaneous T cell lymphomas. In: de Vita V jr, Hellman S, 
Rosenberg S: Principle and practice of Oncology, 4th ed 
Lippincott Philadelphia 2001. 
This article should be referenced as such: 
Cuneo A, Castoldi GL. Cutaneous T-cell lymphomas. Atlas 
Genet Cytogenet Oncol Haematol. 2005; 9(3):241. 


Cutaneous T-cell lymphomas

A Cuneo

GL Castoldi

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http://documents.irevues.inist.fr/bitstream/2042/38217/3/05-2005-CutanTcellID2035.pdf

Cutaneous T-cell lymphomas

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