Traffic Modeling of a Cooperative Charge While Driving System in a Freight Transport Scenario

The aim of this paper is to present a research study on a traffic model developed for analysing the performance of the wireless inductive systems for charging while driving (CWD) fully electric vehicles (FEVs) from both traffic and energy points of view. The design assumptions of the developed traffic model are aimed to simulate in particular a freight distribution service in a fully cooperative traffic environment. In this case, the CWD service could be used to guarantee the minimum state of charge (SOC) of the batteries at the arrival to the depot that allows the vehicles to shortly start with further activities. In this way, the fleet manager could avoid wasting time for the stationary recharge, thus increasing the level of service of the freight distribution. The CWD system is applied to a multilane ring road with several intermediate on-ramp entrances, where the slowest lane is reserved for the charging activities, when authorized vehicles are present. A specific traffic model has been developed and implemented adopting a mesoscopic approach, where vehicle energy needs and charging opportunities affect drivers’ behavior. Overtaking maneuvers, as well as new entries in the CWD lane of vehicles which need to charge, have been modeled by taking into account a fully cooperative driving system among vehicles which manages an adequate gap between consecutive vehicles. Finally, a speed control strategy in which vehicles can be delayed to create an empty time-space slot in the CWD lane, is simulated at a defined node. This type of control, though is simulated to allow extraordinary maintenance operations, which may require a free charging zone for a given time slot, could also be applied to support merging maneuvers for on ramp vehicles

"Charge while driving" for electric vehicles: road traffic modeling and energy assessment

The aim of this research study is to present a method for analyzing the performance of the wireless inductive charge-while-driving (CWD) electric vehicles, from both traffic and energy points of view. To accurately quantify the electric power required from an energy supplier for the proper management of the charging system, a traffic simulation model is implemented. This model is based on a mesoscopic approach, and it is applied to a freight distribution scenario. Lane changing and positioning are managed according to a cooperative system among vehicles and supported by advanced driver assistance systems (ADAS). From the energy point of view, the analyses indicate that the traffic may have the following effects on the energy of the system: in a low traffic level scenario, the maximum power that should be supplied for the entire road is simulated at approximately 9 MW; and in a high level traffic scenario with lower average speeds, the maximum power required by the vehicles in the charging lane increases by more than 50 %

Hydrothermal carbonization of off-specification compost: A byproduct of the organic municipal solid waste treatment

International audienceh i g h l i g h t s HTC of off-specification compost at 180, 220, 250 °C and 1, 3, 8 h reaction time RT. The increase in hydrochar HHV with respect to raw feedstock from 7% to 61%. Hydrochar elemental composition similar to that of peat and lignite for T = 250 °C. Hydrochar thermal stability greatly increased at T = 250 °C and at T = 220 °C when RT = 8 h. HTC results were highly dependent on T, while the effect of RT was much lower. a b s t r a c t The possibility to apply the hydrothermal carbonization (HTC) process to off-specification compost (EWC 19.05.03) at present landfilled was investigated in this work. The aim was to produce a carbonaceous solid fuel for energy valorization, with the perspective of using HTC as a complementary technology to common organic waste treatments. Thus, samples of EWC 19.05.03 produced by a composting plant were processed through HTC in a batch reactor. Analytical activities allowed to characterize the HTC products and their yields. The hydrochar was characterized in terms of heating value, thermal stability and C, H, O, N, S and ash content. The liquid phase was characterized in terms of total organic carbon and mineral content. The composition of the gas phase was measured. Results show that the produced hydrochar has a great potentiality for use as solid fuel

First record of naturalization of <i>Erechtites hieraciifolius</i> (L.) Raf. ex DC. (Asteraceae) in Italy

The plant species Erechtites hieraciifolius (Asteraceae) is here reported for the first time in Italy as a naturalized neophyte in the Classical Karst. The species was observed in 2023 in post-fire forest areas burnt by wildfires in the summer 2022. The features of findings suggest for a naturalization of the species with putative invasive character. This novel occurrence highlights the need for additional research to better understand its colonization and expansion, suggesting the need of early eradication actions

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

The present study demonstrates that Pin1 is a common activator of key pathways involved in diabetic vascular disease in different experimental settings including primary human endothelial cells, knockout mice, and diabetic patients. Gene silencing and genetic disruption of Pin1 prevent hyperglycaemia-induced mitochondrial oxidative stress, endothelial dysfunction, and vascular inflammation. Moreover, we have translated our findings to diabetic patients. In line with our experimental observations, Pin1 up-regulation is associated with impaired flow-mediated dilation, increased oxidative stress, and plasma levels of adhesion molecules. In perspective, these findings may provide the rationale for mechanism-based therapeutic strategies in patients with diabete

Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review

In vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, ie, leukotriene receptor antagonists and synthesis inhibitors, are a class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma and in rhinitis with asthma. We searched MEDLINE database and carried out a manual search on journals specializing in allergy and dermatology for the use of antileukotriene drugs in urticaria. Montelukast might be effective in chronic urticaria associated with aspirin (ASA) or food additive hypersensitivity or with autoreactivity to intradermal serum injection (ASST) when taken with an antihistamine but not in mild or moderate chronic idiopathic urticaria [urticaria without any possible secondary causes (ie, food additive or ASA and other NSAID hypersensitivity, or ASST)]. Evidence for the effectiveness of zafirlukast and the 5-lipoxygenase inhibitor, zileuton, in chronic urticaria is mainly anecdotal. In addition, there is anecdotal evidence of effectiveness of antileukotrienes in primary cold urticaria, delayed pressure urticaria and dermographism. No evidence exists for other physical urticarias, including cholinergic, solar and aquagenic urticarias, vibratory angioedema, and exercise-induced anaphylaxis

The characteristics of different diagnostic tests in adult mild asthmatic patients : comparison with patients with asthma-like symptoms by gastro-oesophageal reflux.

SummaryBackgroundDiagnosing asthma cannot be always easy. It is important to consider the validity of the diagnostic tests, and/or how much more commonly they are positive in patients with asthma compared to healthy subjects and, particularly, to patients with asthma-like symptoms.ObjectiveTo evaluate the validity of diagnostic tests for asthma, in terms of sensitivity, specificity, positive and negative predictive values, in patients with bronchial asthma compared to patients affected by gastro-oesophageal reflux disease (GERD) with asthma-like symptoms, and healthy control subjects without asthma and gastro-oesophageal reflux (GER).DesignSingle-center, cross-sectional, observational study.PatientsWe studied 60 patients with mild asthma, 30 patients with GERD and asthma-like symptoms and 25 healthy control subjects.MeasurementsWe measured provocative concentration of methacholine causing a 20% fall in the forced expiratory volume in 1s (MCh PC20/FEV1), the amplitude percent mean of peak expiratory flow (A%M of PEF), derived from twice-daily readings for >2 weeks, the FEV1/forced vital capacity (FEV1/FVC) ratio, the eosinophil count in blood and in induced sputum and the serum eosinophil cationic protein (ECP) levels.ResultsFEV1/FVC ratio, A%M of PEF, blood eosinophils counts and serum ECP levels were less sensitive and specific when the reference population was composed of patients with asthma-like symptoms by GER. While, MCh PC20/FEV1 and induced sputum eosinophils count were the most sensitive (both 90%) and specific (89% and 92%, respectively) tests.ConclusionOur findings demonstrate that MCh PC20/FEV1 and the induced sputum eosinophil count are the most useful objective tests in patients with mild asthma. All patients with asthma presented both an MCh PC20/FEV1 <1500μg and eosinophils count in the induced sputum >1%

Multi-segment rupture of the 2016 Amatrice-Visso-Norcia seismic sequence (central Italy) constrained by the first high-quality catalog of Early Aftershocks

We present the first high-quality catalog of early aftershocks of the three mainshocks of the 2016 central Italy Amatrice-Visso-Norcia normal faulting sequence. We located 10,574 manually picked aftershocks with a robust probabilistic, non-linear method achieving a significant improvement in the solution accuracy and magnitude completeness with respect to previous studies. Aftershock distribution and relocated mainshocks give insight into the complex architecture of major causative and subsidiary faults, thus providing crucial constraints on multi-segment rupture models. We document reactivation and kinematic inversion of a WNW-dipping listric structure, referable to the inherited Mts Sibillini Thrust (MST) that controlled segmentation of the causative normal faults. Spatial partitioning of aftershocks evidences that the MST lateral ramp had a dual control on rupture propagation, behaving as a barrier for the Amatrice and Visso mainshocks, and later as an asperity for the Norcia mainshock. We hypothesize that the Visso mainshock re-activated also the deep part of an optimally oriented preexisting thrust. Aftershock patterns reveal that the Amatrice Mw5.4 aftershock and the Norcia mainshock ruptured two distinct antithetic faults 3-4 km apart. Therefore, our results suggest to consider both the MST cross structure and the subsidiary antithetic fault in the finite-fault source modelling of the Norcia earthquake.Published69214T. Sismicità dell'ItaliaJCR Journa

Label Free Inhibitor Screening of Hepatitis C Virus (HCV) NS5B Viral Protein Using RNA Oligonucleotide

Globally, over 170 million people (ca. 3% of the World’s population) are infected with the hepatitis C virus (HCV), which can cause serious liver diseases such as chronic hepatitis, evolving into subsequent health problems. Driven by the need to detect the presence of HCV, as an essential factor in diagnostic medicine, the monitoring of viral protein has been of great interest in developing simple and reliable HCV detection methods. Despite considerable advances in viral protein detection as an HCV disease marker, the current enzyme linked immunosorbent assay (ELISA) based detection methods using antibody treatment have several drawbacks. To overcome this bottleneck, an RNA aptamer become to be emerged as an antibody substitute in the application of biosensor for detection of viral protein. In this study, we demonstrated a streptavidin-biotin conjugation method, namely, the RNA aptamer sensor system that can quantify viral protein with detection level of 700 pg mL−1 using a biotinylated RNA oligonucleotide on an Octet optical biosensor. Also, we showed this method can be used to screen inhibitors of viral protein rapidly and simply on a biotinylated RNA oligonucleotide biosensor. Among the inhibitors screened, (−)-Epigallocatechin gallate showed high binding inhibition effect on HCV NS5B viral protein. The proposed method can be considered a real-time monitoring method for inhibitor screening of HCV viral protein and is expected to be applicable to other types of diseases