Analysis of unswept and swept wing chordwise pressure data from an oscillating NACA 0012 airfoil experiment. Volume 1: Technical Report

The unsteady chordwise force response on the airfoil surface was investigated and its sensitivity to the various system parameters was examined. A further examination of unsteady aerodynamic data on a tunnel spanning wing (both swept and unswept), obtained in a wind tunnel, was performed. The main body of this data analysis was carried out by analyzing the propagation speed of pressure disturbances along the chord and by studying the behavior of the unsteady part of the chordwise pressure distribution at various points of the airfoil pitching cycle. It was found that Mach number effects dominate the approach to and the inception of both static and dynamic stall. The stall angle decreases as the Mach number increases. However, sweep dominates the load behavior within the stall regime. Large phase differences between unswept and swept responses, that do not exist at low lift coefficient, appear once the stall boundary is penetrated. It was also found that reduced frequency is not a reliable indicator of the unsteady aerodynamic response in the high angle of attack regime

Parole come molecole: scienza e letteratura in Primo Levi

Il profilo di Primo Levi è stato a lungo quello di chimico e di scrittore per caso e la sua fortuna editoriale, incerta all'inizio, lo dimostra. Oggi non si esita a considerarlo uno tra i più grandi scrittori morali del Novecento per la qualità letteraria del suo stile e per le questioni morali che affronta, l'uomo di fronte al male, le conseguenze dello sviluppo tecnologico, la scelta tra il bene e il male. Nella sua produzione letteraria si contano racconti, romanzi-saggi, poesie, reportages che sono l'esito di una teoria etica sulla funzione e la natura della scrittura letteraria. Il sistema periodico, in questo senso, è una silloge esemplare della maniera di comporre e di inventare storie a partire dai referti casuali del reale

Le forme del racconto tra memoria e utopia fantastica

In questo libro l'opera di Giuseppe Bonaviri \ue8 analizzata da una prospettiva critica nuova: lo sperimentalismo formale e l'espressivismo linguistico dei romanzi della cosiddetta trilogia fantastica, La Divina foresta, Notti sull'altura, L'isola amorosa. I temi cari allo scrittore, il viaggio, le avventure, il senso della vita e della morte, la memoria, offrono lo spunto per intrecciare itinerari fantastico-surreali e per disarticolare le modalit\ue0 proprie del racconto realistico. In linea con le pi\uf9 recenti teorie del fantastico novecentesco, in questo studio si suggerisce l'inserimento dello scrittore siciliano all'interno delle modalit\ue0 formali del 'fantastico del linguaggio'

Damage tolerance analysis of aircraft reinforced panels

This work is aimed at reproducing numerically a campaign of experimental tests performed for the development of reinforced panels, typically found in aircraft fuselage. The bonded reinforcements can significantly reduce the rate of fatigue crack growth and increase the residual strength of the skin. The reinforcements are of two types: stringers and doublers. The former provides stiffening to the panel while the latter controls the crack growth between the stringers. The purpose of the study is to validate a numerical method of analysis that can predict the damage tolerance of these reinforced panels. Therefore, using a fracture mechanics approach, several models (different by the geometry and the types of reinforcement constraints) were simulated with the finite element solver ABAQUS. The bonding between skin and stiffener was taken either rigid or flexible due to the presence of adhesive. The possible rupture of the reinforcements was also considered. The stress intensity factor trend obtained numerically as a function of crack growth was used to determine the fatigue crack growth rate, obtaining a good approximation of the experimental crack propagation rate in the skin. Therefore, different solutions for improving the damage tolerance of aircraft reinforced panels can be virtually tested in this way before performing experiments

Evidence for uteroplacental malperfusion in fetuses with major congenital heart defects.

AIMS: Fetuses affected by congenital heart defects (CHD) are considered to be at increased risk of fetal growth restriction and intrauterine demise. Whether these risks are a direct consequence of fetal CHD or a result of associated uteroplacental dysfunction is not evident from the data of recent studies. The aim of this study was to investigate the prevalence of uteroplacental dysfunction reflected by abnormal uterine artery Doppler indices and reduced fetal growth in CHD pregnancies. METHODS: This is a retrospective case-control study including singleton pregnancies referred for detailed fetal cardiac assessment subsequently diagnosed with or without CHD. Mid-trimester uterine artery Doppler assessment at 20-24 weeks as well as third trimester fetal biometry and arterial Doppler pulsatility indices (PI) were performed. All fetal biometry were converted into centiles and Doppler values to multiples of median (MoM) to adjust for physiological changes with gestation. RESULTS: The study included 811 pregnancies including 153 cases where the fetus was diagnosed with CHD. Mid-pregnancy uterine artery PI was significantly higher in women with fetal CHD compared to controls (0.90MoM vs 0.83MoM; p = 0.006). In the third trimester, median centiles for fetal head circumference (45.4 vs 57.07; p<0.001), abdominal circumference (51.17 vs 55.71; p = 0.014), estimated fetal weight (33.6 vs 56.7; p<0.001) and cerebroplacental ratio (CPR: 0.84MoM vs 0.95MoM; p<0.001) were significantly lower in fetuses with CHD compared to controls. The percentage of small for gestational age births <10th centile (24.0% vs 10.7%; <0.001) and low CPR <0.6MoM (11.7% vs 2.5%; p<0.001) were significantly higher in the fetal CHD cohort. CONCLUSIONS: Mid-pregnancy uterine artery resistance is increased and subsequent fetal biometry reduced in pregnancies with CHD fetuses. These findings suggest that fetal CHD are associated with uteroplacental dysfunction, secondary to impaired maternal uteroplacental perfusion resulting in relative fetal hypoxaemia and reduced fetal growth

Damage tolerance analysis of aircraft reinforced panels

This work is aimed at reproducing numerically a campaign of experimental tests performed for the development of reinforced panels, typically found in aircraft fuselage. The bonded reinforcements can significantly reduce the rate of fatigue crack growth and increase the residual strength of the skin. The reinforcements are of two types: stringers and doublers. The former provides stiffening to the panel while the latter controls the crack growth between the stringers. The purpose of the study is to validate a numerical method of analysis that can predict the damage tolerance of these reinforced panels. Therefore, using a fracture mechanics approach, several models (different by the geometry and the types of reinforcement constraints) were simulated with the finite element solver ABAQUS. The bonding between skin and stiffener was taken either rigid or flexible due to the presence of adhesive. The possible rupture of the reinforcements was also considered. The stress intensity factor trend obtained numerically as a function of crack growth was used to determine the fatigue crack growth rate, obtaining a good approximation of the experimental crack propagation rate in the skin. Therefore, different solutions for improving the damage tolerance of aircraft reinforced panels can be virtually tested in this way before performing experiments

Practical implementation of the Kelly criterion: optimal growth rate, number of trades, and rebalancing frequency for equity portfolios

We develop a general framework to apply the Kelly criterion to the stock market data, and consequently, to portfolio optimization. Under few conditions, using Monte Carlo simulations with different scenarios we prove that the Kelly criterion beats any other approach in many aspects. In particular, it maximizes the expected growth rate and the median of the terminal wealth. We also show that, under a normal distribution of returns, the Kelly criterion has the best performance in the long run. Next, we optimize a portfolio with the Kelly criterion with no leverage and no short selling conditions and show that this portfolio lays in the mean-variance efficient frontier and has higher expected return and higher variance, although it is less diversified, respect to the tangent portfolio optimized under the Markowitz approach. Finally, we implement a dynamic strategy applied on the European stock market data and compare the results between the tangent and the optimal Kelly portfolios. In a dynamic setting, the rolling Kelly portfolio outperforms competitors particularly in the case of rebalanced portfolios optimized with a 2-years window width

Cost utility analysis of Remdesivir and Dexamethasone treatment for hospitalised COVID-19 patients - a hypothetical study

Background: Sars-Cov-2 is a novel corona virus associated with significant morbidity and mortality. Remdesivir and Dexamethasone are two treatments that have shown to be effective against the Sars-Cov-2 associated disease. However, a cost-effectiveness analysis of the two treatments is still lacking. Objective: The cost-utility of Remdesivir, Dexamethasone and a simultaneous use of the two drugs with respect to standard of care for treatment Covid-19 hospitalized patients is evaluated, together with the effect of Remdesivir compared to the base model but based on alernative assumptions. Methods: A decision tree for an hypothetical cohort of Covid-19 hospitalized patients, from an health care perspective and a one year horizon is specified. Efficacy data are retrieved from a literature review of clinical trials, whilst costs and utility are obtained from other published studies. Results: Remdesivir, if health care costs are related to the days of hospitalization, is a cost saving strategy. Dexamethasone is cost effective with an ICER of $5208/QALY, and the concurrent use of Remdesivir and Dexamethasone is the most favorable strategy for higher level of willingness to pay thresholds. Moreover, if Remdesivir has a positive effect on mortality the utility is three times higher respect to base case. Whereas, if health care costs are not related to the length of patient hospitalization Remdesivir has an ICER respect to standard of care of$384412.8/QALY gained, which is not cost effective. We also find that Dexaamethasone is cost effective respect to standard care if we compute the cost for live saved with an ICER of $313.79 for life saved. The uncertainty of the model parameters is also tested through both a one-way deterministic sensitivity analysis and a probabilistic sensitivity analysis. Conclusion: We find that the use of Remdesivir and/or Dexamethasone is effective from an economic standpoint