Movimientos sociales, redes sociales y Web 2.0: el caso del Movimiento por la Paz con Justicia y Dignidad

Estudios empíricos han señalado que la interacción en las plataformas de los movimientos sociales suele ser muy baja, aunque otros autores argumentan que la Web 2.0 aumenta las posibilidades de participación y de interacción. Este artículo presenta un análisis cuali-cuantitativo de la página Facebook del Movimiento por la Paz con Justicia y Dignidad. El objetivo consiste en investigar si esta página constituye un espacio de diálogo e interacción o si en cambio prevalece una lógica de difusión de contenidos online. Los resultados revelan que Facebook aparece como espacio de publicación de informaciones, no como red para un debate participativo.Empirical studies have pointed out that interaction in the technological platforms used by social movements is usually very low, even if other authors have argued that Web 2.0 increases the possibilities for participation and interaction. This article presents a quali-quantitative analysis of the Facebook page of the Movement for Peace with Justice and Dignity. The aim is to investigate whether this page is a space for dialogue and interaction or whether the dominant logic is the simple diffusion of online content. Results reveal that Facebook appears as a space for the publication of information, rather than a network for building a participatory debate

Native plants from Argentina reported as effective against Leishmania spp.

Leishmaniasis represents a spectrum of diseases caused by infection with protozoan pathogens of the genus Leishmania. It is a major neglected tropical disease associated with high rates of disability and death, with extended endemic areas in the Americas. Despite current therapeutic approaches, current treatments for leishmaniasis are unsatisfactory due to high associated toxicity, cost, complex administration and the emergence of resistant strains. Because of this, efforts have greatly increased over the last decade to identify novel compounds with anti-leishmanial properties. Thus, one strategy in the search for new compounds is the screening of molecules purified from plant sources. The current work reviewed the available information about the Argentinean natural sources reported as effective against Leishmania spp; including: its relevant chemical compounds, efficiency and applied methodology. Reported studies need to be considered as precursors works to extend the search between the profuse native plants from Argentina.Fil: Lozano, Esteban Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; ArgentinaFil: Hapon, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo. ; ArgentinaFil: Cargnelutti, D. E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo. ; ArgentinaFil: Gamarra Luques, Carlos Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentin

By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy

Basal-like breast cancer is an aggressive tumor subtype with a poor response to conventional therapies. Tumor formation and relapse are sustained by a cell subset of Breast Cancer Stem Cells (BrCSCs). Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 (Plk1) down-regulation. Moreover, miR-100 favors BrCSC differentiation, converting a basal like phenotype into luminal. It induces the expression of a functional estrogen receptor (ER) and renders basal-like BrCSCs responsive to hormonal therapy. The key role played by miR-100 in breast cancer free-survival is confirmed by the analysis of a cohort of patients' tumors, which shows that low expression of miR-100 is a negative prognostic factor and is associated with gene signatures of high grade undifferentiated tumors. Our findings indicate a new possible therapeutic strategy, which could make aggressive breast cancers responsive to standard treatments

Expresión de Rab22 en macrófagos infectados con Leishmania braziliensis

Leishmania braziliensis es un protozoario flagelado digénico que produce leishmaniosis cutánea y muco-cutánea en el noroeste argentino