Manuale d'uso per l'inserimento dei rapporti tecnici in OA@INAF

Il presente Manuale d’uso fornisce istruzioni su come inserire nel repository istituzionale ad accesso aperto INAF i rapporti tecnici prodotti dal personale dopo il 1° gennaio 2019

The rare books collection of Capodimonte Astronomical Observatory will be shortly on the web: the ancient science is available to everyone

This paper describes a project dedicated to the preservation, promotion and fruition on the web of the rare books collection of Capodimonte Astronomical Observatory. The project, promoted by INAF-Capodimonte Astronomical Observatory, was supported by the Campania Region through European funds. The final act of the project was the publication of a bibliographical catalog, Le Cinquecentine dell'Osservatorio Astronomico di Capodimonte, addressed to specialized users (historians of science and bibliophiles)

Le cinquecentine dell'Osservatorio Astronomico di Capodimonte

Il catalogo, realizzato con fondi POR Campania FESR 2007/2013 (Obiettivo Operativo 1.10 "La cultura come risorsa") nell'ambito del progetto denominato "Recupero, valorizzazione, digitalizzazione e immissione in rete dei beni della Biblioteca dell'INAF-Osservatorio Astronomico di Capodimonte", descrive, secondo un modello che individua e ricostruisce la copia ideale, le edizioni a stampa del del XV e XVI secolo conservate nel fondo antico della biblioteca dell'OAC

The Rare Book Collection of Capodimonte Astronomical Observatory Will be on the Web: Ancient Science Available to Everyone

This paper describes a project for the preservation, promotion, and creation of a website for the rare book collection of Capodimonte Astronomical Observatory. The project, promoted by INAF—Capodimonte Astronomical Observatory, was supported by the Campania Region through European funds. The final component of the project was the publication of a bibliographical catalog, Le Cinquecentine dell'Osservatorio Astronomico di Capodimonte, which was addressed to specialized users, including historians of science and bibliophiles

Reversal of neurological deficits by painless nerve growth factor in a mouse model of Rett syndrome

: Rett syndrome is a rare genetic neurodevelopmental disease, affecting 1 in over 10,000 females born worldwide, caused by de novo mutations in the X-chromosome-located methyl-CpG-binding protein 2 (MeCP2) gene. Despite the great effort put forth by the scientific community, a therapy for this devastating disease is still needed. Here, we tested the therapeutic effects of a painless mutein of the Nerve Growth Factor, called human NGF painless (hNGFp), via a non-invasive intranasal delivery in female MeCP2+/- mice. Of note, previous work had demonstrated a broad biodistribution of hNGFp in the mouse brain by the nasal delivery route. We report that (1) the long-term lifelong treatment of MeCP2+/- mice with hNGFp, starting at 2 months of age, increased the chance of survival while also greatly improving behavioral parameters. Furthermore, when we assessed the phenotypic changes brought forth by (2) a short-term 1-month-long hNGFp-treatment, starting at 3 months of age (right after the initial presentation of symptoms), we observed the rescue of a well-known neuronal target population of NGF, cholinergic neurons in the medial septum. Moreover, we reveal a deficit in microglial morphology in MeCP2+/- mice, completely reversed in treated animals. This effect on microglia is in line with reports showing microglia to be a TrkA-dependent non-neuronal target cell population of NGF in the brain. To understand the immunomodulatory activity of hNGFp, we analyzed the cytokine profile after hNGFp treatment in MeCP2+/- mice, to discover that the treatment recovered the altered expression of key neuroimmune-communication molecules, such as fractalkine. The overall conclusion is that hNGFp delivered intranasally can ameliorate symptoms in the MeCP2+/- model of Rett syndrome, by exerting strong neuroprotection with a dual mechanism of action: directly on target neurons and indirectly via microglia

INAF Technical Reports: Grey Literature in OA@INAF, the Open Access Repository of the National Institute for Astrophysics

INAF Technical reports are documents concerning methodologies, projects, instrumental applications and innovation, data harvesting techniques, handbooks and software produced in the various disciplinary fields

Time trend prevalence of artificial nutrition counselling in a university hospital.

Abstract Objectives The negative effects of malnutrition on the prognosis of hospitalized patients are well documented; however, less known is the awareness and knowledge of health care professionals about this complication. The aim of this study was to evaluate the trend of the requests for nutritional consultation in years and the prescription of artificial nutrition (AN), for adult patients at a university hospital in southern Italy in the years 2004, 2008, 2012, and 2016 to assess the progress of medical teams concerning awareness of hospital malnutrition. Methods This was a retrospective study that evaluated the time trend of nutritional consultation requests and related prescription of AN, for adult patients at a university hospital in southern Italy in the years 2004, 2008, 2012, and 2016. Of 112 233 inpatients, 2505 received a nutritional consultation with the prescription of AN. Results The number of patients on AN increased from 507 of 33 240 (1.52%) in 2004 to 730 of 29 195 (2.5%) in 2008 (P The request for AN was quite equally distributed between surgical (51.5%) and medical wards (48.5%), with a prevalence among patients with oncologic diseases (806 patients [65.6%]). As for nononcologic diseases, 20.4% involved the gastrointestinal tract and 6.3% the nervous system. Throughout the 12 y of observation, parenteral nutrition was the main prescribed support (59.8%) followed by oral nutritional supplements (26.1%) and enteral nutrition (9.3%). Mean nutritional intervention duration was 11 d (±10.8 d). Conclusions The request of AN for hospitalized patients increased over time, probably owing to improved medical consciousness of the potential risks for malnutrition and the availability of a specialized clinical nutrition team

Clinical Features, Cardiovascular Risk Profile, and Therapeutic Trajectories of Patients with Type 2 Diabetes Candidate for Oral Semaglutide Therapy in the Italian Specialist Care

Introduction: This study aimed to address therapeutic inertia in the management of type 2 diabetes (T2D) by investigating the potential of early treatment with oral semaglutide. Methods: A cross-sectional survey was conducted between October 2021 and April 2022 among specialists treating individuals with T2D. A scientific committee designed a data collection form covering demographics, cardiovascular risk, glucose control metrics, ongoing therapies, and physician judgments on treatment appropriateness. Participants completed anonymous patient questionnaires reflecting routine clinical encounters. The preferred therapeutic regimen for each patient was also identified. Results: The analysis was conducted on 4449 patients initiating oral semaglutide. The population had a relatively short disease duration (42%  60% of patients, and more often than sitagliptin or empagliflozin. Conclusion: The study supports the potential of early implementation of oral semaglutide as a strategy to overcome therapeutic inertia and enhance T2D management