1,171 research outputs found
Frequency locking to a high-finesse Fabry-Perot cavity of a Frequency doubled Nd:YAG laser used as the optical phase modulator
We report on the frequency locking of a frequency doubled Nd:YAG laser to a
45 000 finesse, 87-cm-long, Fabry-Perot cavity using a modified form of the
Pound-Drever-Hall technique. Necessary signals, such as light phase modulation
and frequency correction feedback, are fed direcly to the infrared pump laser.
This is sufficient to achieve a stable locking of the 532 nm visible beam to
the cavity, also showing that the doubling process does not degrade laser
performances.Comment: submitted to Review of Scientific Instrument
Optical production and detection of dark matter candidates
The PVLAS collaboration is at present running, at the Laboratori Nazionali di
Legnaro of I.N.F.N., Padova, Italy, a very sensitive optical ellipsometer
capable of measuring the small rotations or ellipticities which can be acquired
by a linearly polarized laser beam propagating in vacuum through a transverse
magnetic feld (vacuum magnetic birefringence). The apparatus will also be able
to set new limits on mass and coupling constant of light scalar/pseudoscalar
particles coupling to two photons by both producing and detecting the
hypothetical particles. The axion, introduced to explain parity conservation in
strong interactions, is an example of this class of particles, all of which are
considered possible dark matter candidates. The PVLAS apparatus consists of a
very high finesse (> 140000), 6.4 m long, Fabry-Perot cavity immersed in an
intense dipolar magnetic field (~6.5 T). A linearly polarized laser beam is
frequency locked to the cavity and analysed, using a heterodyne technique, for
rotation and/or ellipticity acquired within the magnetic field.Comment: presented at "Frontier Detectors for Frontier Physics - 8th Pisa
Meeting on Advanced Detectors - May 21-27, 2000" to appear in: Nucl.Instr.
and Meth.
Anti-cyclic-citrullinated-protein-antibodies in psoriatic arthritis patients: how autoimmune dysregulation could affect clinical characteristics, retention rate of methotrexate monotherapy and first line biotechnological drug survival. A single center retrospective study
Aim: Occasional findings of anti-cyclic-citrullinated-protein-antibodies (anti-CCP) were rarely observed in psoriatic arthritis (PsA). The aim of our study is to evaluate whether the presence of anti-CCP can determine different clinical subsets and influence methotrexate monotherapy survival, and biotechnological drug retention rate. Methods: We conducted a retrospective study on PsA patients. All patients were required to fulfill the CASPAR criteria for PsA, and to present juxta-articular osteo-proliferative signs at X-ray. The exclusion criteria were age less than 18 years old, satisfaction of rheumatoid arthritis classification criteria, and seropositivity for rheumatoid factor. Clinical characteristics, anti-CCP titer, drug survival and comorbidities information were recorded for each patient. Statistical signiïŹcance was set at p â©œ 0.05. Results: Of 407 patients with PsA screened 113 were recruited. Twelve patients were anti-CCP positive. Methotrexate monotherapy survival was shorter in patients with anti-CCP (150 ± 48.3 weeks versus 535.3 ± 65.3 weeks; p = 0.026) [discontinuation risk hazard ratio (HR) = 2.389, 95% confidence interval (CI) 1.043, 5.473; p = 0.039] than those without. Significant shorter survival of first-line biotechnological drugs (b-DMARDs) was observed in the anti-CCP positive group than in that without (102.05 ± 24.4 weeks versus 271.6 ± 41.7 weeks; p = 0.005) with higher discontinuation risk (HR = 3.230, 95% CI 1.299, 8.028; p = 0.012). A significant higher rate of multi-failure (more than second-line b-DMARDs) was found in anti-CCP positive patients than in those without (50% versus 14%, p = 0.035). Conclusion: Anti-CCP in PsA could be suggestive of more severe disease, with worse drug survival of both methotrexate monotherapy and first-line b-DMARDs, and higher chance to be b-DMARDs multi-failure. So, they can be considered for more intensive clinical management of these patients
Bone Involvement in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a wide variability of clinical manifestations due to the potential involvement of several tissues and internal organs, with a relapsing and remitting course. Dysregulation of innate and adaptive immune systems, due to genetic, hormonal and environmental factors, may be responsible for a broad spectrum of clinical manifestations, affecting quality of life, morbidity and mortality. Bone involvement represents one of the most common cause of morbidity and disability in SLE. Particularly, an increased incidence of osteoporosis, avascular necrosis of bone and osteomyelitis has been observed in SLE patients compared to the general population. Moreover, due to the improvement in diagnosis and therapy, the survival of SLE patient has improved, increasing long-term morbidities, including osteoporosis and related fractures. This review aims to highlight bone manifestations in SLE patients, deepening underlying etiopathogenetic mechanisms, diagnostic tools and available treatment
Ellipsometry noise spectrum, suspension transfer function measurement and closed-loop control of the suspension system in the Q & A experiment
The Q & A experiment, aiming at the detection of vacuum birefringence
predicted by quantum electrodynamics, consists mainly of a suspended 3.5 m
Fabry-Perot cavity, a rotating permanent dipole magnet and an ellipsometer. The
2.3 T magnet can rotate up to 10 rev/s, introducing an ellipticity signal at
twice the rotation frequency. The X-pendulum gives a good isolation ratio for
seismic noise above its main resonant frequency 0.3 Hz. At present, the
ellipsometry noise decreases with frequency, from 1*10^{-5} rad Hz^{-1/2} at 5
Hz, 2*10^{-6} rad Hz^{-1/2} at 20 Hz to 5*10^{-7} rad Hz^{-1/2} at 40 Hz. The
shape of the noise spectrum indicates possible improvement can be made by
further reducing the movement between the cavity mirrors. From the preliminary
result of yaw motion alignment control, it can be seen that some peaks due to
yaw motion of the cavity mirror was suppressed. In this paper, we first give a
schematic view of the Q & A experiment, and then present the measurement of
transfer function of the compound X-pendulum-double pendulum suspension. A
closed-loop control was carried out to verify the validity of the measured
transfer functions. The ellipsometry noise spectra with and without yaw
alignment control and the newest improvement is presented.Comment: 7 pages, 5 figures, presented in 6th Edoardo Amaldi Conference on
Gravitational Waves, June 2005, Okinawa Japan and submitted to Journal of
Physics: Conference Series. Some modifications are made according to the
referee's comments: mainly to explain the relation between the displacement
of cavity mirror and the ellipticity noise spectru
Experimental observation of optical rotation generated in vacuum by a magnetic field
We report the experimental observation of a light polarization rotation in
vacuum in the presence of a transverse magnetic field. Assuming that data
distribution is Gaussian, the average measured rotation is (3.9+/-0.5)e-12
rad/pass, at 5 T with 44000 passes through a 1m long magnet, with lambda = 1064
nm. The relevance of this result in terms of the existence of a light, neutral,
spin-zero particle is discussed.Comment: 11 pages, 4 figures, submitted to Physical Review Letters Comment to
version 2: minor changes to abstract and final discussion. Added 2 references
Comment to version 3: corrected minor typographical errors, eliminated the
distinction between scalar and pseudoscalar in the particle interpretation of
the resul
Exploring the ability of LARS2 carboxy-terminal domain in rescuing the MELAS phenotype
The m.3243A>G mutation within the mitochondrial mt-tRNALeu(UUR) gene is the most prevalent variant linked to mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome. This pathogenic mutation causes severe impairment of mitochondrial protein synthesis due to alterations of the mutated tRNA, such as reduced aminoacylation and a lack of post-transcriptional modification. In transmitochondrial cybrids, overexpression of human mitochondrial leucyl-tRNA synthetase (LARS2) has proven effective in rescuing the phenotype associated with m.3243A>G substitution. The rescuing activity resides in the carboxy-terminal domain (Cterm) of the enzyme; however, the precise molecular mechanisms underlying this process have not been fully elucidated. To deepen our knowledge on the rescuing mechanisms, we demonstrated the interactions of the Cterm with mutated mt-tRNALeu(UUR) and its precursor in MELAS cybrids. Further, the effect of Cterm expression on mitochondrial functions was evaluated. We found that Cterm ameliorates de novo mitochondrial protein synthesis, whilst it has no effect on mt-tRNALeu(UUR) steady-state levels and aminoacylation. Despite the complete recovery of cell viability and the increase in mitochondrial translation, Cterm-overexpressing cybrids were not able to recover bioenergetic competence. These data suggest that, in our MELAS cell model, the beneficial effect of Cterm may be mediated by factors that are independent of the mitochondrial bioenergetics
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