Special section : Base closures in the Fifth District

Federal Reserve District, 5th ; Job security

Investigation of the Shared Genetic Influences on Bipolar Disorder, Borderline Personality Disorder and Regional Brain Structures

Background: The heritabilities of bipolar disorder (BD) and borderline personality disorder (BPD) are 80% and 65%, respectively, indicating substantial genetic contributions to both disorders. BD and BPD are often comorbid, and both disorders have a polygenic architecture. These variants are thought to subtly affect multiple pathways, associated with structural brain abnormalities commonly observed in patients with BD and BPD. Brain regions have been shown to be highly heritable and under distinct genetic influences. However, the overlap in genetic risk between BD and BPD and altered brain regions, respectively, has not yet been determined. Aims and Objectives: The aim of this project was to determine whether genetic risk for BD and BPD overlaps with genetic risk for altered brain regions. Methods: Genome-wide association study (GWAS) summary statistics for BD (Ncases=20,352; Ncontrols= 31,358), BPD (Ncase=998; Ncontrol=1,545), eight subcortical brain volumes (nucleus accumbens, amygdala, caudate nucleus, hippocampus, pallidum, putamen and thalamus) and intracranial volume (ICV) (N=27,087), and cortical surface area and thickness (N=37,479) were obtained. Pleiotropy and concordance were assessed using SNP-Effect Concordance Analysis. Conditional false discovery rate (cFDR) was used to condition BD and BPD GWAS results on genetic variants that influence brain regions. Linkage Disequilibrium Score Regression was used to examine genome-wide correlations between BD, BPD and brain regions. Mendelian randomization was used to test for causal associations between BD, BPD and each brain region, respectively. Results: There was evidence of significant pleiotropy and positive concordance between BD and BPD (ppleiotropy=5x10-4; pconcordance=1x10-6, OR=1.29). Significant pleiotropy was observed between BD and the thickness of several cortical regions and two gyri, namely the lateral occipital (p=2.25x10-5), pars triangularis (p=1.1x10-4), rostral anterior cingulate regions (p=2.18x10-4) and post central (p=7.9x10-6) and supramarginal gyri (p=1.45x10-7). Significant positive concordance was noted between BPD and thickness of the lateral occipital region (p=3x10-4; OR=1.02). After conditioning BD onto BPD and each regional brain GWAS, 171 additional variants were significantly associated with BD (FDR<0.05). Three additional SNPs were significantly associated with BPD when conditioned on thickness of the lateral orbitofrontal, lingual, precentral and supramarginal regions. Discussion: The findings here of genetic overlap between BD, BPD and altered brain structure, while novel, are consistent with previous work. The cFDR analyses, highlight synapse and neurotransmitter regulation as a key underlying mechanism between BD and altered brain regions. Further fine-grained delineation of the role of the environment in these relationships and the inclusion of non-European populations are critical next steps, as they may provide insight into risk factors, new areas of treatment and aid in early detection of at risk individuals

Access to Justice Annotated Bibliography: February 2019 V.6

The revised and updated version of our Annotated Bibliography on the SRL Phenomenon and Access to Justice

The effect of human activities on moisture content of soils and underlying permafrost from the McMurdo Sound region, Antarctica

Soils and the underlying permafrost from undisturbed sites and sites that had been disturbed by construction activities at Marble Point and Pram Point in the McMurdo Sound region were sampled from excavated pits and drill cores. Gravimetric moisture (ice) contents and particle size distribution were determined. Volumetric moisture contents were calculated from these results. At undisturbed sites soil moisture contents within the active layer (to c. 60 cm depth) were low and ranged from 0.5% by weight at the soil surface to 10% above the permafrost. The permafrost was generally completely saturated with ice, but sometimes contained considerable excess ice, with ice contents rising as high as 80% by volume. At disturbed sites, soil moisture contents within the active layer were similar to those of the undisturbed sites (generally <10% by weight) but within the permafrost, moisture contents were lower and less variable than in the undisturbed sites, rarely exceeding 20% by weight. The release of considerable quantities of water from the permafrost as a result of land disturbance during construction activities caused stream flows, soil shrinkage, land slumping and salinisation, resulting in significant permanent environmental damage. At Marble Point there has been no significant re-establishment of icy permafrost in the disturbed soils in the 30 years since land disturbance occurred

Cultivating a New Educator: Teacher and Students Sharing Growth

This is Megan Campell-Looney\u27s final portfolio for her M.A. in English (with a specialization in teaching). It includes a reflective narrative and four revised pieces: A Murderous Moral Tale: Depictions of the Ideal Victorian in Wilkie Collins\u27 Jezebel\u27s Daughter, Critical Thinking and Counseling Through the Power of Literature, Developing an American Identity: Syllabus and Assignment Plan, and Evolving and Adapting Rhetoric and Theory: Indigenous Theory Writing Back. The portfolio focuses on research and study that developed Looney\u27s classroom pedagogy and philosophy. Students and educators both must write back to gain the agency needed for growth

Doctor of Philosophy

dissertationSpintronic devices are currently being researched as next-generation alternatives to traditional electronics. Electronics, which utilize the charge-carrying capabilities of electrons to store information, are fundamentally limited not only by size constraints, but also by limits on current flow and degradation, due to electro-migration. Spintronics devices are able to overcome these limitations, as their information storage is in the spin of electrons, rather than their charge. By using spin rather than charge, these current-limiting shortcomings can be easily overcome. However, for spintronic devices to be fully implemented into the current technology industry, their capabilities must be improved. Spintronic device operation relies on the movement and manipulation of spin-polarized electrons, in which there are three main processes that must be optimized in order to maximize device efficiencies. These spin-related processes are: the injection of spin-polarized electrons, the transport and manipulation of these carriers, and the detection of spin-polarized currents. In order to enhance the rate of spin-polarized injection, research has been focused on the use of alternative methods to enhance injection beyond that of a simple ferromagnetic metal/semiconductor injector interface. These alternatives include the use of oxide-based tunnel barriers and the modification of semiconductors and insulators for their use as ferromagnetic injector materials. The transport of spin-polarized carriers is heavily reliant on the optimization of materials' properties in order to enhance the carrier mobility and to quench spin-orbit coupling (SOC). However, a certain degree of SOC is necessary in order to allow for the electric-field, gate-controlled manipulation of spin currents. Spin detection can be performed via both optical and electrical techniques. Using electrical methods relies on the conversion between spin and charge currents via SOC and is often the preferred method for device-based applications. This dissertation presents experimental results on the use of oxides for fulfilling the three spintronic device requirements. In the case of spin injection, the study of dilute magnetic dielectrics (DMDs) shows the importance of doping on the magnetic properties of the resulting tunnel barriers. The study of spin transport in ZnO has shown that, even at room temperature, the spin diffusion length is relatively long, on the order of 100 nm. These studies have also probed the spin relaxation mechanics in ZnO and have shown that Dyakonov-Perel spin relaxation, operating according to Fermi-Dirac statistics, is the dominant spin relaxation mechanism in zinc oxide. Finally, spin detection in ZnO has shown that, similar to other semiconductors, by modifying the resistivity of the ZnO thin films, the spin Hall angle (SHA) can be enhanced to nearly that of metals. This is possible by enhancing extrinsic SOC due to skew-scattering from impurities as well as phonons. In addition, thermal spin injection has also been detected using ZnO, which results support the independently measured inverse spin-Hall effect studies. The work represented herein illustrates that oxide materials have the potential to enhance spintronic device potential in all processes pertinent to spintronic applications

Self-Represented Litigants & Legal Doctrines of “Vexatiousness” - An Interim Report from The National Self-Represented Litigants Project

The Self-Represented Litigants Case Law Database Project (the “CLD” Project) is a research initiative of the National-Self-Represented Litigants Project and as such, an extension of Director Julie Macfarlane’s original 2013 Study on Self-Represented Litigants (“SRLs”). The CLD tracks emerging jurisprudence across Canada which affects SRLs. The development of the CLD was driven by the fact that no other organization in Canada was systematically tracking and analyzing case decisions on SRLs. To date, NSRLP researchers have identified more than 600 important cases that fall within our parameters (below) and over 360 Canadian decisions have been analyzed and entered into the database. As the database builds, it is possible to see trends emerging from the data. When a judge determines that a litigant’s behavior has abused the court’s processes, the litigant is designated as “vexatious”, and consequently barred from accessing the court. Courts are given the authority to designate a litigant as vexatious by using their respective rules of court, legislation, or by common law. Although not completely uniform, the elements required to find a litigant vexatious are similar across in Canada. The CLD examines those cases in which a vexatious designation has been applied to a litigant who is an SRL, or where there is other discussion of an SRL’s behaviour in terms that suggest vexatiousness, but without a formal designation as such (see “vexatiousness lite” below at section 4

Electrical transport in ultrathin NdNiO3 films

pre-printElectrical transport properties in ultrathin NdNiO3 films grown on single crystal LaAlO3 (001) substrate were characterized. Films with thicknesses ranging from 0.6 nm to 12 nm were grown using a pulsed laser technique. Four probe resistivity as a function of temperature measurements indicated a strong dissipation of strain effects from 0.6 nm to 6 nm as well as the presence of defects in the 12 nm sample. A proposed mechanism of kinetically stable glassy phase formation explains the time dependence of the resistivity in both cooling and heating cycles

Chronic Pain Through the Occupational Therapy Lens

We as occupational therapy students at the University of Southern Maine partnered with The Cedars which is a skilled nursing facility in Portland, Maine. Their partnership guided our project with searching for evidence on the role of occupational therapy within the geriatric population who experience chronic pain. Chronic pain can be hard to manage and has the possibility of inhibiting one’s quality of life. Evidence shows how occupational therapists have an important role in working with patients who have chronic pain. Quality evidence has supported an array of interventions within the scope of occupational therapy to help improve one’s quality of life. Our findings conclude the current occupational therapy interventions for chronic pain patients are adaptive equipment, lifestyle redesign, cognitive behavioral therapy, pain self-management, mindfulness, and online mind-body programs. Within these interventions positive outcome measurements for the patients entailed improvements with occupational performance, pain management, physical functioning, and psychosocial well-being