66 research outputs found
Tikhonov adaptively regularized gamma variate fitting to assess plasma clearance of inert renal markers
The Tk-GV model fits Gamma Variates (GV) to data by Tikhonov regularization (Tk) with shrinkage constant, λ, chosen to minimize the relative error in plasma clearance, CL (ml/min). Using 169Yb-DTPA and 99mTc-DTPA (n = 46, 8–9 samples, 5–240 min) bolus-dilution curves, results were obtained for fit methods: (1) Ordinary Least Squares (OLS) one and two exponential term (E1 and E2), (2) OLS-GV and (3) Tk-GV. Four tests examined the fit results for: (1) physicality of ranges of model parameters, (2) effects on parameter values when different data subsets are fit, (3) characterization of residuals, and (4) extrapolative error and agreement with published correction factors. Test 1 showed physical Tk-GV results, where OLS-GV fits sometimes-produced nonphysical CL. Test 2 showed the Tk-GV model produced good results with 4 or more samples drawn between 10 and 240 min. Test 3 showed that E1 and E2 failed goodness-of-fit testing whereas GV fits for t > 20 min were acceptably good. Test 4 showed CLTk-GV clearance values agreed with published CL corrections with the general result that CLE1 > CLE2 > CLTk-GV and finally that CLTk-GV were considerably more robust, precise and accurate than CLE2, and should replace the use of CLE2 for these renal markers
Mobile Phone Data for Children on the Move: Challenges and Opportunities
Today, 95% of the global population has 2G mobile phone coverage and the
number of individuals who own a mobile phone is at an all time high. Mobile
phones generate rich data on billions of people across different societal
contexts and have in the last decade helped redefine how we do research and
build tools to understand society. As such, mobile phone data has the potential
to revolutionize how we tackle humanitarian problems, such as the many suffered
by refugees all over the world. While promising, mobile phone data and the new
computational approaches bring both opportunities and challenges. Mobile phone
traces contain detailed information regarding people's whereabouts, social
life, and even financial standing. Therefore, developing and adopting
strategies that open data up to the wider humanitarian and international
development community for analysis and research while simultaneously protecting
the privacy of individuals is of paramount importance. Here we outline the
challenging situation of children on the move and actions UNICEF is pushing in
helping displaced children and youth globally, and discuss opportunities where
mobile phone data can be used. We identify three key challenges: data access,
data and algorithmic bias, and operationalization of research, which need to be
addressed if mobile phone data is to be successfully applied in humanitarian
contexts.Comment: 13 pages, book chapte
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
The CD1d pathway present lipid antigens resulting in the activation of iNKT cells but the complete pathway remains to be fully elucidated. Here, Chandra et al. use an siRNA screen and identify Mrp1 as crucial for CD1d lipid presentation and activation of iNKT in the context of Streptococcus pneumoniae infection
Respectful leadership:Reducing performance challenges posed by leader role incongruence and gender dissimilarity
We investigate how respectful leadership can help overcome the challenges for follower performance that female leaders face when working (especially with male) followers. First, based on role congruity theory, we illustrate the biases faced by female leaders. Second, based on research on gender (dis-)similarity, we propose that these biases should be particularly pronounced when working with a male follower. Finally, we propose that respectful leadership is most conducive to performance in female leader–male follower dyads compared with all other gender configurations. A multi-source field study (N = 214) provides partial support for our hypothesis. While our hypothesized effect was confirmed, respectful leadership seems to be generally effective for female leaders irrespective of follower gender, thus lending greater support in this context to the arguments of role congruity rather than gender dissimilarity
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