La inclinacion española

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Contiene, además: El conde las legumbres, del mismo auto

Las harpías en Madrid ; y Tiempo de regocijo

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201

Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet

Maternal obesity is associated with increased risk of developing diabetes, obesity and premature death in adult offspring. Mid-life diabetes, hypertension and hypercholesterolaemia are risk factors for the development of sporadic Alzheimer's disease (AD). A key pathogenic feature of AD is the accumulation of β-amyloid (Aβ) in the brain. The purpose of this study was to investigate the effect of high fat diet feeding during early life on Aβ pathology in the Tg2576 mouse model of AD. Female mice were fed a standard (C) or high fat (HF) diet before mating and during gestation and lactation. At weaning, male offspring were fed a C diet. Significantly higher levels of guanidine-soluble Aβ and plaque loads were observed in the hippocampi of 11-month old Tg2576 mice born to mothers fed a HF diet. Changes in the extracellular matrix led to increased retention of Aβ within the parenchyma. These data support a role for maternal and gestational health on the health of the aged brain and pathologies associated with AD and may provide a novel target for both the prevention and treatment of AD

La Garduña de Sevilla y anzuelo de las bolsas

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

Saynete nuevo Intitulado El gitano Canuto Mojarra o El dia de toros en Sevilla : para trece personas

Fernández Gómez, Juan F. Catálogo de entremeses y sainetes del siglo XVIII, 654El autor es Juan Ignacio González del CastilloDía de toros en CádizPrecede al tít.: "190.

Hannibal : escena lírica original ó soliloquio unipersonal : en metro endecasílabo castellano

El autor es Juan Ignacio González del Castillo, según Jerónimo Herrera Navarro en Catálogo de autores teatrales del Siglo XVIIIPrecede al tít.: "41"Datos de imp. obtenidos del colofó

Early Prediction of Movie Box Office Success based on Wikipedia Activity Big Data

Use of socially generated "big data" to access information about collective states of the minds in human societies has become a new paradigm in the emerging field of computational social science. A natural application of this would be the prediction of the society's reaction to a new product in the sense of popularity and adoption rate. However, bridging the gap between "real time monitoring" and "early predicting" remains a big challenge. Here we report on an endeavor to build a minimalistic predictive model for the financial success of movies based on collective activity data of online users. We show that the popularity of a movie can be predicted much before its release by measuring and analyzing the activity level of editors and viewers of the corresponding entry to the movie in Wikipedia, the well-known online encyclopedia.Comment: 13 pages, Including Supporting Information, 7 Figures, Download the dataset from: http://wwm.phy.bme.hu/SupplementaryDataS1.zi