2,120 research outputs found
Outbreak of Aeromonas hydrophila wound infections association with mud football
On 16 February 2002, a total of 26 people presented to the emergency department of the local hospital in the rural town of Collie in southwest Western Australia with many infected scratches and pustules distributed over their bodies. All of the patients had participated in a “mud football” competition the previous day, in which there had been 100 participants. One patient required removal of an infected thumbnail, and another required surgical debridement of an infected toe. Aeromonas hydrophila was isolated from all 3 patients from whom swab specimens were obtained. To prepare the mud football fields, a paddock was irrigated with water that was pumped from an adjacent river during the 1-month period before the competition. A. hydrophila was subsequently isolated from a water sample obtained from the river. This is the first published report of an outbreak of A. hydrophila wound infections associated with exposure to mud.Hassan Vally, Amanda Whittle, Scott Cameron, Gary K. Dowse and Tony Watso
Repulsively bound atom pairs in an optical lattice
Throughout physics, stable composite objects are usually formed via
attractive forces, which allow the constituents to lower their energy by
binding together. Repulsive forces separate particles in free space. However,
in a structured environment such as a periodic potential and in the absence of
dissipation, stable composite objects can exist even for repulsive
interactions. Here we report on the first observation of such an exotic bound
state, comprised of a pair of ultracold atoms in an optical lattice. Consistent
with our theoretical analysis, these repulsively bound pairs exhibit long
lifetimes, even under collisions with one another. Signatures of the pairs are
also recognised in the characteristic momentum distribution and through
spectroscopic measurements. There is no analogue in traditional condensed
matter systems of such repulsively bound pairs, due to the presence of strong
decay channels. These results exemplify on a new level the strong
correspondence between the optical lattice physics of ultracold bosonic atoms
and the Bose-Hubbard model, a correspondence which is vital for future
applications of these systems to the study of strongly correlated condensed
matter systems and to quantum information.Comment: 5 pages, 4 figure
Barriers to primary care responsiveness to poverty as a risk factor for health
<p>Abstract</p> <p>Background</p> <p>Poverty is widely recognized as a major determinant of poor health, and this link has been extensively studied and verified. Despite the strong evidentiary link, little work has been done to determine what primary care health providers can do to address their patients' income as a risk to their health. This qualitative study explores the barriers to primary care responsiveness to poverty as a health issue in a well-resourced jurisdiction with near-universal health care insurance coverage.</p> <p>Methods</p> <p>One to one interviews were conducted with twelve experts on poverty and health in primary care in Ontario, Canada. Participants included family physicians, specialist physicians, nurse practitioners, community workers, advocates, policy experts and researchers. The interviews were analysed for anticipated and emergent themes.</p> <p>Results</p> <p>This study reveals provider- and patient-centred structural, attitudinal, and knowledge-based barriers to addressing poverty as a risk to health. While many of its findings reinforce previous work in this area, this study's findings point to a number of areas front line primary care providers could target to address their patients' poverty. These include a lack of provider understanding of the lived reality of poverty, leading to a failure to collect adequate data about patients' social circumstances, and to the development of inappropriate care plans. Participants also pointed to prejudicial attitudes among providers, a failure of primary care disciplines to incorporate approaches to poverty as a standard of care, and a lack of knowledge of concrete steps providers can take to address patients' poverty.</p> <p>Conclusions</p> <p>While this study reinforces, in a well-resourced jurisdiction such as Ontario, the previously reported existence of significant barriers to addressing income as a health issue within primary care, the findings point to the possibility of front line primary care providers taking direct steps to address the health risks posed by poverty. The consistent direction and replicability of these findings point to a refocusing of the research agenda toward an examination of interventions to decrease the health impacts of poverty.</p
The development and application of a new tool to assess the adequacy of the content and timing of antenatal care
Abstract
Background: Current measures of antenatal care use are limited to initiation of care and number of visits. This
study aimed to describe the development and application of a tool to assess the adequacy of the content and
timing of antenatal care.
Methods: The Content and Timing of care in Pregnancy (CTP) tool was developed based on clinical relevance for
ongoing antenatal care and recommendations in national and international guidelines. The tool reflects minimal
care recommended in every pregnancy, regardless of parity or risk status. CTP measures timing of initiation of care,
content of care (number of blood pressure readings, blood tests and ultrasound scans) and whether the
interventions were received at an appropriate time. Antenatal care trajectories for 333 pregnant women were then
described using a standard tool (the APNCU index), that measures the quantity of care only, and the new CTP tool.
Both tools categorise care into 4 categories, from ‘Inadequate’ (both tools) to ‘Adequate plus’ (APNCU) or
‘Appropriate’ (CTP). Participants recorded the timing and content of their antenatal care prospectively using diaries.
Analysis included an examination of similarities and differences in categorisation of care episodes between the
tools.
Results: According to the CTP tool, the care trajectory of 10,2% of the women was classified as inadequate, 8,4%
as intermediate, 36% as sufficient and 45,3% as appropriate. The assessment of quality of care differed significantly
between the two tools. Seventeen care trajectories classified as ‘Adequate’ or ‘Adequate plus’ by the APNCU were
deemed ‘Inadequate’ by the CTP. This suggests that, despite a high number of visits, these women did not receive
the minimal recommended content and timing of care.
Conclusions: The CTP tool provides a more detailed assessment of the adequacy of antenatal care than the
current standard index. However, guidelines for the content of antenatal care vary, and the tool does not at the
moment grade over-use of interventions as ‘Inappropriate’. Further work needs to be done to refine the content
items prior to larger scale testing of the impact of the new measure
The liver is a common non-exocrine target in primary Sjögren's syndrome: A retrospective review
BACKGROUND: The autoimmune destruction of exocrine glands that defines primary Sjögren's syndrome (1°SS) often extends to non-exocrine organs including the liver. We aimed to determine the prevalence of liver disease in patients with 1°SS and to evaluate the association of this complication with other non-exocrine features and serologic markers of autoimmunity and systemic inflammation. METHODS: We reviewed 115 charts of patients with 1°SS and further analyzed the 73 cases that fulfilled the European Epidemiology Center Criteria, seeking evidence for clinical and subclinical liver disease. RESULTS: Liver function tests had been determined in 59 of the 73 patients. Of those, 29 patients (49.1%) had abnormal liver function tests including 20.3% with clinically overt hepatic disease. Liver disease was the most common non-exocrine feature in this cohort. Risk factors for abnormal liver function tests were distributed similarly between the patients with and without liver disease. In 60% of patients with abnormal liver function tests no explanation for this complication was found except for 1°SS. Liver involvement was significantly more common in 1°SS patients who also had evidence of lung, kidney and hematological abnormalities. Patients with abnormal liver function tests were also more likely to have an elevated sedimentation rate and a positive anti-ENA during the course of their disease. CONCLUSION: Liver involvement is a common complication in 1°SS. Its presence correlates with systemic disease. We consider that this complication should be routinely sought in patients with 1°SS, especially when a positive anti-ENA or evidence of systemic inflammation is found
A Mott insulator of fermionic atoms in an optical lattice
In a solid material strong interactions between the electrons can lead to
surprising properties. A prime example is the Mott insulator, where the
suppression of conductivity is a result of interactions and not the consequence
of a filled Bloch band. The proximity to the Mott insulating phase in fermionic
systems is the origin for many intriguing phenomena in condensed matter
physics, most notably high-temperature superconductivity. Therefore it is
highly desirable to use the novel experimental tools developed in atomic
physics to access this regime. Indeed, the Hubbard model, which encompasses the
essential physics of the Mott insulator, also applies to quantum gases trapped
in an optical lattice. However, the Mott insulating regime has so far been
reached only with a gas of bosons, lacking the rich and peculiar nature of
fermions. Here we report on the formation of a Mott insulator of a repulsively
interacting two-component Fermi gas in an optical lattice. It is signalled by
three features: a drastic suppression of doubly occupied lattice sites, a
strong reduction of the compressibility inferred from the response of double
occupancy to atom number increase, and the appearance of a gapped mode in the
excitation spectrum. Direct control of the interaction strength allows us to
compare the Mott insulating and the non-interacting regime without changing
tunnel-coupling or confinement. Our results pave the way for further studies of
the Mott insulator, including spin ordering and ultimately the question of
d-wave superfluidity.Comment: 6 pages, 4 figure
Behaviour change interventions to reduce second-hand smoke (SHS) exposure at home in pregnant women - A systematic review and intervention appraisal
Abstract Background Second-hand smoke (SHS) exposure during pregnancy is associated with poor pregnancy and foetal outcomes. Theory-based behaviour change interventions (BCI) have been used successfully to change smoking related behaviours and offer the potential to reduce exposure of SHS in pregnant women. Systematic reviews conducted so far do not evaluate the generalisability and scalability of interventions. The objectives of this review were to (1) report the BCIs for reduction in home exposure to SHS for pregnant women; and (2) critically appraise intervention-reporting, generalisability, feasibility and scalability of the BCIs employed. Methods Standard methods following PRISMA guidelines were employed. Eight databases were searched from 2000 to 2015 in English. The studies included used BCIs on pregnant women to reduce their home SHS exposure by targeting husbands/partners. The Workgroup for Intervention Development and Evaluation Research (WIDER) guidelines were used to assess intervention reporting. Generalisability, feasibility and scalability were assessed against criteria described by Bonell and Milat. Results Of 3479 papers identified, six studies met the inclusion criteria. These studies found that BCIs led to increased knowledge about SHS harms, reduction or husbands quitting smoking, and increased susceptibility and change in level of actions to reduce SHS at home. Two studies reported objective exposure measures, and one reported objective health outcomes. The studies partially followed WIDER guidelines for reporting, and none met all generalisability, feasibility and scalability criteria. Conclusions There is a dearth of literature in this area and the quality of studies reviewed was moderate to low. The BCIs appear effective in reducing SHS, however, weak study methodology (self-reported exposure, lack of objective outcome assessment, short follow-up, absence of control group) preclude firm conclusion. Some components of the WIDER checklist were followed for BCI reporting, scalability and feasibility of the studies were not described. More rigorous studies using biochemical and clinical measures for exposures and health outcomes in varied study settings are required. Studies should report interventions in detail using WIDER checklist and assess them for generalisability, feasibility and scalability. Trial registration CRD40125026666
Relative fat oxidation is higher in children than adults
Background: Prepubescent children may oxidize fatty acids more readily than adults. Therefore, dietary fat needs would be higher for children compared with adults. The dietary fat recommendations are higher for children 4 to 18 yrs (i.e., 25 to 35% of energy) compared with adults (i.e., 20 to 35% of energy). Despite this, many parents and children restrict dietary fat for health reasons. Methods: This study assessed whether rates of fat oxidation are similar between prepubescent children and adults. Ten children (8.7 ± 1.4 yr, 33 ± 13 kg mean ± SD) in Tanner stage 1 and 10 adults (41.6 ± 8 yr, 74 ± 13 kg) were fed a weight maintenance diet for three days to maintain body weight and to establish a consistent background for metabolic rate measurements (all foods provided). Metabolic rate was measured on three separate occasions before and immediately after breakfast and for 9 hrs using a hood system (twice) or a room calorimeter (once) where continuous metabolic measurements were taken. Results: During all three sessions whole body fat oxidation was higher in children (lower RQ) compared to adults (mean RQ= 0.84 ± .016 for children and 0.87 ± .02, for adults, p < 0.02). Although, total grams of fat oxidized was similar in children (62.7 ± 20 g/24 hrs) compared to adults (51.4 ± 19 g/24 hrs), the grams of fat oxidized relative to calorie expenditure was higher in children (0.047 ± .01 g/kcal, compared to adults (0.032 ± .01 p < 0.02). Females oxidized more fat relative to calorie expenditure than males of a similar age. A two way ANOVA showed no interaction between gender and age in terms of fax oxidation. Conclusion: These data suggest that fat oxidation relative to total calorie expenditure is higher in prepubescent children than in adults. Consistent with current dietary guidelines, a moderate fat diet is appropriate for children within the context of a diet that meets their energy and nutrient needs. Originally published Nutrition Journal, Vol. 6, No. 19, Aug 200
Measuring agreement of administrative data with chart data using prevalence unadjusted and adjusted kappa
YesFunding provided by the Open Access Authors Fund
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