Transverse Shear Effects in Bimodular Composite Laminates

A closed-form solution for the Timoshenko-type shear correction coefficient (K2) governing the deflection of bimodular composite laminates in cylindrical bending is presented. The bending- stress distribution for a laminate constructed of bimodular materials (which have different elastic moduli in tension and compression) is used in the two-dimensional equilibrium equation to obtain the transverse shear-stress distribution. This shear-stress distribution is used to obtain expressions for the shear correction coefficient (based on equrvalent shear strain energy) and the maximum dimensionless transverse shear stress (τxz) max. Finally, the effects of the elastic-constant ratios on the neutral-surface location and shear correction coefficient for laminates consisting of either unimodular or bimodular materials are studied.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Free Vibrations of Multilayer Anisotropic Cylindrical Shells

A theoretical analysis is presented for determining the free vibra tional characteristics of thin-walled, circular cylindrical shells with layers of anisotropic elastic material arbitrarily laminated either sym metrically or unsymmetrically about the shell middle surface. An arbitrarily laminated, anisotropic version of Love's first-approximation shell theory is used to formulate the coupled equations of motion. An exact solution with a classical checkerboard nodal pattern is found for the case of a shell with specially orthotropic layers arbitrarily laminated and with freely supported ends. For a boron/epoxy composite cylinder, the significant effect of omitting bending-stretching coupling is demonstrated and various lamination arrangements are investigated. Also, a general solution is presented for the axisymmetric modes of an arbitrarily laminated anisotropic shell. Finally, an approximate solution, using a combination of two helical-nodal-pattern modes, is obtained for the unsymmetric modes of the same general class of shell with a supported boundary condition.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Catholic Healthcare Organizations and the Articulation of Their Identity

Contains fulltext : 69947.pdf (publisher's version ) (Open Access

X chromosome inactivation in a female carrier of a 1.28 mb deletion encompassing the human X inactivation centre

X chromosome inactivation (XCI) is a mechanism specifically initiated in female cells to silence one X chromosome, thereby equalizing the dose of X-linked gene products between male and female cells. XCI is regulated by a locus on the X chromosome termed the X-inactivation centre (XIC). Located within the XIC is XIST, which acts as a m

Decalcification of Breast Cancer Bone Metastases with EDTA Does Not Affect ER, PR, and HER2 Results

In metastatic breast cancer (MBC), expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) guides treatment selection. In case of bone-only metastatic disease, ER, PR, and HER2 status assessment may be hampered by decalcification. We aimed to determine the optimal decalcification method, and to study discordance of receptor expression between paired primary breast tumors and optimally decalcified bone metastases. First, decalcification was simulated using acetic acid, hydrochloric/formic acid, and EDTA on 12 primary breast carcinomas. ER, PR, and HER2 immunohistochemistry (IHC) and HER2 in situ hybridization (ISH) were assessed, before and after the 3 decalcification methods. EDTA was considered t