Phase diagram of quarter-filled band organic salts, [EDT-TTF-CONMe2]2X, X = AsF6 and Br

An investigation of the P/T phase diagram of the quarter-filled organic conductors, [EDT-TTF-CONMe2]2X, is reported on the basis of transport and NMR studies of two members, X=AsF6 and Br of the family. The strongly insulating character of these materials in the low pressure regime has been attributed to a remarkably stable charge ordered state confirmed by 13C NMR and the only existence of 1/4 Umklapp e-e scattering favoring a charge ordering instead of the 1D Mott localization seen in (TM)2X which are quarter-filled compounds with dimerization. A non magnetic insulating phase instead of the spin density wave state is stabilized in the deconfined regime of the phase diagram. This sequence of phases observed under pressure may be considered as a generic behavior for 1/4-filled conductors with correlations

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Multi-phase coexistence in the organic conductor (TMTSF)₂ReO₄

We present here a complete description of the phase diagram of (TMTSF)2ReO4 when pressure is applied at room temperature using resistivity measurements along both a and c-axes. In a large range of pressure and temperature, the semiconducting order characterized by the wave-vector $\rm q1=(1/2,1/2,1/2)$ coexists with the various phases (spin density wave and superconductivity) exhibited by the metallic ordered phase ($\rm q2=(0,1/2,1/2)$) down to the lowest temperatures