Quadruple Series Equation InvolvingGeneralized- BatemanK- Functions

Formal solution four series equation involving generalized Bateman k Functions is given is this paper.Finally, the solution of four series equation is reduceto Freadholm integrals equation of second timein one independent which can be solve by some numerical method

Kinetics of zinc transformation in calciorthids soils of western Rajasthan, India

The present study was undertaken to investigate the kinetics of transformation process of applied and native Zn as influenced by soil moisture regime, available moisture and organic matter additions in Aridisols of western Rajasthan. The incubation experiment was conducted with exact amount of the soil samples (250 g), put in a number of small containers, made of corning glass. Three levels of moisture regimes i.e. field capacity (W0), continuous submergence (W1), alternate submergence and saturation (W2) and two levels of organic matter as starch at 0 per cent (M1) and 0.5 per cent (M2) of the soil weight; and two levels of zinc i.e. native (N) and applied (A) (Zn @ 5 mg kg-1 soil as ZnSO4.7 H2O). The soils then incubated for 30, 60 and 90 days. Destructive sampling was done after each incubation period, and then different fractions of Zn were sequentially extracted by different extracting solutions and determined with the help of atomic absorption spectrophotometer. Based on the results, it can be concluded that the transformation of Zn is largely controlled by organic matter, moisture regimes and Zn application due to considerable changes in the chemical and electrochemical properties of soil and thereby influence the transformation of zinc. Organic matter application significantly increased Zn fractions due to the retention of Zn on exchange complex owing to producing organic acid by decomposition of organic matter in soil. Further, the results showed that if such condition was maintained in the field, and it increased the availability of Zn for different crops in Aridisols

Air Hybrid Bicycle

This project is design, fabrication and development of a design and fabrication of pneumatic bicycle it is rear wheel drive. The conceptual design of this model is taken from manually operated bicycle. The complete body looks like a bicycle in which manual operation followed. This product is a pneumatic vehicle, useful for handicapped people, and also normal persons. The power transmission takes place from rear wheel through chain drive. The entire arrangement of power transmission by means of connecting rod of the actuator is taken along with the chain sprocket. When the Compressor is connected to, it would give a driving force due the pressure at which air is sent. Only one person is allowed on the bicycle at any time. The material, mild steel ischoose as a main structure fastening by joint, and main components of this project is , air cylinder, solenoid valve, electrical control unit, pneumatic actuator, power transmitting chain, sprocket wheel, two wheeler rear wheel components of model attach by welding, part by part create then be fabricating together. At the end of the project, the model is tested by several people and their comment then being recorded and performed some tests. The concept of compressed air bicycle in practice reduces the air pollution to large extend as its exhaust is nothing but air

Role of remittances in India's economic growth

India has been among the top ten remittance recipient countries in the world since the 1970s. In the context of the ongoing worldwide recession and uncertain export prospects, mobilisation of foreign exchange earnings has assumed greater importance. Given the intensification of financial sector development together with relatively stable capital inflows (FDI and ODA) and the efforts towards formalising the channels of remittance inflows, we find that remittances and the interaction between remittances and financial sector development have had a positive and significant effect on growth over the last four decades (1970–2009). In the light of these findings, it is proposed that the proactive policy measures in India should continue for encouraging remittance inflows for long-term growth and development

Prodrug design of NSAIDs: synthesis and pharmacological profiles of amide prodrugs of etodolac with amino acids

Novel amide prodrugs of etodolac with various amino acids were synthesized and the structures were confirmed by elemental and spectral analyses. In vitro hydrolytic studies in various simulated fluids confirmed the hydrolysis of prodrugs in colon. The prodrugs showed an improved anti-inflammatory activity of 74.4 %, 79.3 %, 73.4 % and 74.5 % when compared to 42.5 % of etodolac. Further the mean ulcer index of 10.1, 8.7, 6.8 and 7.3 were observed for the prodrugs while a score of 22.6 for etodolac. The histopathological studies showed less ulceration in the gastric region when treated with prodrugs, thereby proving the prodrugs to be better in action as compared to etodolac and are advantageous in having less gastrointestinal side effects.Colegio de Farmacéuticos de la Provincia de Buenos Aire

In Vitro Anti Bacterial Potential of Different Extracts of Tagetes Erecta and Tagetes Patula

The antimicrobial activity of cold aqueous, hot aqueous and methanol extracts of Tagetes erecta and Tagetes patula flowers was evaluated by agar well diffusion method against ten different pathogenic species of Gram-negative bacteria viz.,  Escherichia coli, Proteus vulgaris, Proteus mirabilis, Aeromonas sobria, Aeromonas hydrophila, Plesiomonas shigelloides, Salmonella enterica serotype Typhi, Salmonella enterica serotype Typhimurium, Salmonella enterica serotype Aboni and Salmonella enterica serotype Enteritidis, four different pathogenic species of Gram-positive bacteria such as Bacillus subtilis, Bacillus cereus, Bacillus circulans and Staphylococcus aureus. Methanol extract of Tagetes erecta at 40 mg/ml concentration was found to have better inhibitory activity when compared to cold and hot aqueous extracts, which were evident through the increased zones of inhibition against Gram-negative and Gram-positive bacteria. Methanol extract of Tagetes erecta showed highest inhibition zone of 26 mm against Aeromonas sorbia, Aeromonas hydrophila, Staphylococcus aureus (MTCC7405) and Staphylococcus aureus (clinical isolate), while lowest inhibition zone of 12 mm with Bacillus subtilis. Similarly, hot aqueous extracts of Tagetes patula had better activity as compare to cold aqueous extract and methanol extract at 40mg/ml concentration. It had highest and lowest zone of inhibition with Proteus vulgaris OX19 (30 mm) and Staphylococcus aureus (clinical iolate) (13 mm) respectively. Minimal inhibitory concentrations (MICs) were between concentrations of 20 - 160 mg/ml with aqueous or methanol extracts of Tagetes erecta and Tagetes patula flowers for most of the tested bacteria. Results of antimicrobial activity of extracts indicate that they possess potential broad spectrum antibacterial activity. Keywords: Tagetes flower extracts, antibacterial activit

Prodrug design of NSAIDs: synthesis and pharmacological profiles of amide prodrugs of etodolac with amino acids

Novel amide prodrugs of etodolac with various amino acids were synthesized and the structures were confirmed by elemental and spectral analyses. In vitro hydrolytic studies in various simulated fluids confirmed the hydrolysis of prodrugs in colon. The prodrugs showed an improved anti-inflammatory activity of 74.4 %, 79.3 %, 73.4 % and 74.5 % when compared to 42.5 % of etodolac. Further the mean ulcer index of 10.1, 8.7, 6.8 and 7.3 were observed for the prodrugs while a score of 22.6 for etodolac. The histopathological studies showed less ulceration in the gastric region when treated with prodrugs, thereby proving the prodrugs to be better in action as compared to etodolac and are advantageous in having less gastrointestinal side effects.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways

10.1371/journal.pone.0032476PLoS ONE73

PREPARE AND EVALUATE MUCOADHESIVE FORMULATIONS OF LAMIVUDINE WITH BETTER CONTROLLED/ SUSTAINED DRUG RELEASE PROFILE

The aim of present study was to formulate & evaluate the mucoadhesive sustained release formulations of lamivudine and to fulfill this aim, two mucoadhesive formulations Gels and Tablets were prepared by using three different polymers: HPMC K15, poloxamer 407 & carbopol 934. Three mucoadhesive gel and nine tablet formulations were prepared and evaluated for various parameters. All three gels were able to give sustained release up to 12 hours. Tablet formulations, F1 to F5 failed to fulfill the aim. Only F6, F7, F8 & F9 formulations were selected, as all gave sustained release up to 12 hours, except F6, which gave sustained release profile only till 7 hours. From the drug release plots, it was concluded that the type of polymer and concentration of polymer have distinct effect on in vitro drug release profile and all the formulations follow first order mechanism with anomalous diffusion or non-fickian diffusion, except carbopol gel and poloxamer tablets. Carbopol gel follows zero order release rate with super case II transport and poloxamer tablets (F6) follow higuchi with non-fickian diffusion. It is concluded that mucoadhesive formulations of lamivudine can be prepared for sustaining its release. And the successful outcome of the present study also encourage for further studies to assess the ability of the mucoadhesive formulations of lamivudine in providing an effective sustained and safe therapy for AIDS