Updated Nucleosynthesis Constraints on Unstable Relic Particles

We revisit the upper limits on the abundance of unstable massive relic particles provided by the success of Big-Bang Nucleosynthesis calculations. We use the cosmic microwave background data to constrain the baryon-to-photon ratio, and incorporate an extensively updated compilation of cross sections into a new calculation of the network of reactions induced by electromagnetic showers that create and destroy the light elements deuterium, he3, he4, li6 and li7. We derive analytic approximations that complement and check the full numerical calculations. Considerations of the abundances of he4 and li6 exclude exceptional regions of parameter space that would otherwise have been permitted by deuterium alone. We illustrate our results by applying them to massive gravitinos. If they weigh ~100 GeV, their primordial abundance should have been below about 10^{-13} of the total entropy. This would imply an upper limit on the reheating temperature of a few times 10^7 GeV, which could be a potential difficulty for some models of inflation. We discuss possible ways of evading this problem.Comment: 40 pages LaTeX, 18 eps figure

Polymorphism: an evaluation of the potential risk to the quality of drug products from the Farmácia Popular Rede Própria

Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns

On the rotation-activity correlation for active binary stars

We present an investigation of rotation-activity correlations using International Ultraviolet Explorer (IUE) SWP measurements of the CIV emission line at 1550 Å for 72 active binary systems. We use a standard stellar evolution code to derive non-empirical Rossby numbers, R0, for each star in our sample and compare the resulting CIV rotation-activity correlation to that found for empirically derived values of the Rossby number and that based on rotation alone. For dwarf stars our values of R0 do not differ greatly from empirical ones and we find a corresponding lack of improvement in correlation. Only a marginal improvement in correlation is found for evolved components in our sample. We discuss possible additional factors, other than rotation or convection, that may influence the activity levels in active binaries. Our observational data imply, in contrast to the theoretical predictions of convective motions, that activity is only weakly related to mass in evolved stars. We conclude that current dynamo theory is limited in its application to the study of active stars because of the uncertainty in the angular velocity-depth profile in stellar interiors and the unknown effects of binarity and surface gravity