574 research outputs found
Occurrence of methicillin-resistant Staphylococcus aureus in surface waters near industrial hog operation spray fields
Industrial hog operations (IHOs) have been identified as a source of antibiotic-resistant Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA). However, few studies have investigated the presence of antibiotic-resistant S. aureus in the environment near IHOs, specifically surface waters proximal to spray fields where IHO liquid lagoon waste is sprayed. Surface water samples (n = 179) were collected over the course of approximately one year from nine locations in southeastern North Carolina and analyzed for the presence of presumptive MRSA using CHROMagar MRSA media. Culture-based, biochemical, and molecular tests, as well as matrix-assisted laser desorption/ionization-time of flight mass spectrometry were used to confirm that isolates that grew on CHROMagar MRSA media were S. aureus. Confirmed S. aureus isolates were then tested for susceptibility to 16 antibiotics and screened for molecular markers of MRSA (mecA, mecC) and livestock adaptation (absence of scn). A total of 12 confirmed MRSA were detected in 9 distinct water samples. Nine of 12 MRSA isolates were also multidrug-resistant (MDRSA [i.e., resistant to ≥ 3 antibiotic classes]). All MRSA were scn-positive and most (11/12) belonged to a staphylococcal protein A (spa) type t008, which is commonly associated with humans. Additionally, 12 confirmed S. aureus that were methicillin-susceptible (MSSA) were recovered, 7 of which belonged to spa type t021 and were scn-negative (a marker of livestock-adaptation). This study demonstrated the presence of MSSA, MRSA, and MDRSA in surface waters adjacent to IHO lagoon waste spray fields in southeastern North Carolina. To our knowledge, this is the first report of waterborne S. aureus from surface waters proximal to IHOs
The VLBA Imaging and Polarimetry Survey at 5 GHz
We present the first results of the VLBA Imaging and Polarimetry Survey
(VIPS), a 5 GHz VLBI survey of 1,127 sources with flat radio spectra. Through
automated data reduction and imaging routines, we have produced publicly
available I, Q, and U images and have detected polarized flux density from 37%
of the sources. We have also developed an algorithm to use each source's I
image to automatically classify it as a point-like source, a core-jet, a
compact symmetric object (CSO) candidate, or a complex source. The mean ratio
of the polarized to total 5 GHz flux density for VIPS sources with detected
polarized flux density ranges from 1% to 20% with a median value of about 5%.
We have also found significant evidence that the directions of the jets in
core-jet systems tend to be perpendicular to the electric vector position
angles (EVPAs). The data is consistent with a scenario in which ~24% of the
polarized core-jets have EVPAs that are anti-aligned with the directions of
their jet components and which have a substantial amount of Faraday rotation.
In addition to these initial results, plans for future follow-up observations
are discussed.Comment: 36 pages, 3 tables, 13 figures; accepted for publication in Ap
Uniqueness Theorem for Generalized Maxwell Electric and Magnetic Black Holes in Higher Dimensions
Based on the conformal energy theorem we prove the uniqueness theorem for
static higher dimensional electrically and magnetically charged black holes
being the solution of Einstein (n-2)-gauge forms equations of motion. Black
hole spacetime contains an asymptotically flat spacelike hypersurface with
compact interior and non-degenerate components of the event horizon.Comment: 7 pages, RevTex, to be published in Phys.Rev.D1
A longitudinal investigation of repressive coping and ageing
This is an Accepted Manuscript of an article published by Taylor & Francis in Aging & Mental Health on October 2016, available online: http://www.tandfonline.com/doi/full/10.1080/13607863.2015.1060941.Two studies investigated the possibility that repressive coping is more prevalent in older adults and that this represents a developmental progression rather than a cohort effect. Study 1 examined repressive coping and mental health cross-sectionally in young and old adults. Study 2 examined whether there was a developmental progression of repressive coping prevalence rates in a longitudinal sample of older adults.Peer reviewedFinal Accepted Versio
On manifolds with nonhomogeneous factors
We present simple examples of finite-dimensional connected homogeneous spaces
(they are actually topological manifolds) with nonhomogeneous and nonrigid
factors. In particular, we give an elementary solution of an old problem in
general topology concerning homogeneous spaces
Black Holes from Cosmic Rays: Probes of Extra Dimensions and New Limits on TeV-Scale Gravity
If extra spacetime dimensions and low-scale gravity exist, black holes will
be produced in observable collisions of elementary particles. For the next
several years, ultra-high energy cosmic rays provide the most promising window
on this phenomenon. In particular, cosmic neutrinos can produce black holes
deep in the Earth's atmosphere, leading to quasi-horizontal giant air showers.
We determine the sensitivity of cosmic ray detectors to black hole production
and compare the results to other probes of extra dimensions. With n \ge 4 extra
dimensions, current bounds on deeply penetrating showers from AGASA already
provide the most stringent bound on low-scale gravity, requiring a fundamental
Planck scale M_D > 1.3 - 1.8 TeV. The Auger Observatory will probe M_D as large
as 4 TeV and may observe on the order of a hundred black holes in 5 years. We
also consider the implications of angular momentum and possible exponentially
suppressed parton cross sections; including these effects, large black hole
rates are still possible. Finally, we demonstrate that even if only a few black
hole events are observed, a standard model interpretation may be excluded by
comparison with Earth-skimming neutrino rates.Comment: 30 pages, 18 figures; v2: discussion of gravitational infall, AGASA
and Fly's Eye comparison added; v3: Earth-skimming results modified and
strengthened, published versio
Toward an internally consistent astronomical distance scale
Accurate astronomical distance determination is crucial for all fields in
astrophysics, from Galactic to cosmological scales. Despite, or perhaps because
of, significant efforts to determine accurate distances, using a wide range of
methods, tracers, and techniques, an internally consistent astronomical
distance framework has not yet been established. We review current efforts to
homogenize the Local Group's distance framework, with particular emphasis on
the potential of RR Lyrae stars as distance indicators, and attempt to extend
this in an internally consistent manner to cosmological distances. Calibration
based on Type Ia supernovae and distance determinations based on gravitational
lensing represent particularly promising approaches. We provide a positive
outlook to improvements to the status quo expected from future surveys,
missions, and facilities. Astronomical distance determination has clearly
reached maturity and near-consistency.Comment: Review article, 59 pages (4 figures); Space Science Reviews, in press
(chapter 8 of a special collection resulting from the May 2016 ISSI-BJ
workshop on Astronomical Distance Determination in the Space Age
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Constraints on the mass spectrum of primordial black holes and braneworld parameters from the high-energy diffuse photon background
We investigate the spectral shape of a high-energy diffuse photon emitted by
evaporating primordial black holes (PBHs) in the Randall-Sundrum type II (RS2)
braneworld. In their braneworld scenario, the nature of small PBHs is
drastically modified from the ordinary four-dimensional case for the following
two reasons. (i) dropping Hawking temperature, which equivalently lengthens the
lifetime of the individual PBH due to the change of space-time topology and
(ii) the effective increase of the total amount of PBHs caused by accretion
during the earliest part of the radiation-dominated epoch, the brane
high-energy phase. From studies of the expected spectral shape and its
dependence on braneworld parameters, we obtain two qualitatively distinctive
possibilities of constraints on the braneworld PBHs from the observations of
diffuse high-energy photon background. If the efficiency of accretion in the
high-energy phase exceeds a critical value, the existence of the extra
dimension gives a more stringent upper bound on the abundance of PBHs than the
4D case and a small length scale for the extra dimension is favored. On the
contrary, in the case below the critical accretion efficiency, we find that the
constraint on the PBH abundance can be relaxed by a few orders of magnitude in
exchange for the existence of the large extra dimension; its size may be even
bounded in the region above 10^{19} times 4D Planck length scale provided the
rest mass energy density of the PBHs relative to energy density of radiation is
actually larger than 10^{-27} (4D upper bound) at their formation time. The
above analytical studies are also confirmed numerically, and an allowed region
for braneworld parameters and PBH abundance is clearly obtained.Comment: 16 pages, 8 figures, REVTeX4; version published in PR
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