Resonant leptogenesis in a predictive SO(10) grand unified model

An SO(10) grand unified model considered previously by the authors featuring lopsided down quark and charged lepton mass matrices is successfully predictive and requires that the lightest two right-handed Majorana neutrinons be nearly degenerate in order to obtain the LMA solar neutrino solution. Here we use this model to test its predictions for baryogenesis through resonant-enhanced leptogenesis. With the conventional type I seesaw mechanism, the best predictions for baryogenesis appear to fall a factor of three short of the observed value. However, with a proposed type III seesaw mechanism leading to three pairs of massive pseudo-Dirac neutrinos, resonant leptogenesis is decoupled from the neutrino mass and mixing issues with successful baryogenesis easily obtained.Comment: 22 pages including 1 figure; published version with reference adde

Neutrinos in 5D SO(10) Unification

We study neutrino physics in a 5D supersymmetric SO(10) GUT. We analyze several different choices for realizing the See-Saw mechanism. We find that the "natural" scale for the Majorana mass of right-handed neutrinos depends critically on whether the right-handed neutrinos are located in the bulk or localized on a brane. In the former case, the effective Majorana mass is "naturally" of order the compactification scale, about 10^{14} GeV. Note, this is the value necessary for obtaining a light tau neutrino mass approximately 10^{-2} eV which, within the context of hierarchical neutrino masses, is the right order of magnitude to explain atmospheric neutrino oscillations. On the other-hand when the right-handed neutrino is localized on the brane, the effective Majorana mass is typically larger than the compactification scale. Nevertheless with small parameters of order 1/10 - 1/30, an effective Majorana mass of order 10^{14} GeV can be accommodated. We also discuss the constraints on model building resulting from the different scenarios for locating the right-handed neutrinos.Comment: 24 page

Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes

The mechanism of induction of apoptosis by the novel anti-cancer drug 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) was investigated in p53-defective SV40 immortalized rat hepatocytes (CWSV1). Exposure to 12 uμM ET-18-OCH3 for 36 h induced apoptosis as determined using classical morphological features and agarose gel electrophoresis of genomic DNA. Increased levels of reactive oxygen species (ROS) were detected spectrophotometrically using a nitroblue tetrazolium (NBT) assay in cells treated with ET-18-OCH3. Both the increased generation of ROS and the induction of apoptosis were inhibited when cells were treated concurrently with ET-18-OCH3 in the presence of the antioxidant α-to-copherol. Similar results were achieved when cells were switched acutely to choline-deficient (CD) medium in the presence of the antioxidant. The possible role of mitochondria in the generation of ROS was investigated. Both ET-18-OCH3 and CD decreased the phosphatidylcholine (PC) content of mitochondrial and associated membranes, which correlated with depolarization of the mitochondrial membrane as analyzed using 5,5′,6,6′-tetramethylbenzimidazolcarbocyanine iodide (JC-1), a sensitive probe of mitochondrial membrane potential. Rotenone, an inhibitor of the mitochondrial electron transport chain, significantly reduced the intracellular level of ROS and prevented mitochondrial membrane depolarization, correlating with a reduction of apoptosis in response to either ET-18-OCH3 or CD. Taken together, these results suggest that the form of p53-independent apoptosis induced by ET-18-OCH3 is mediated by alterations in mitochondrial membrane PC, a loss of mitochondrial membrane potential, and the release of ROS, resulting in completion of apoptosis

U(2)-like Flavor Symmetries and Approximate Bimaximal Neutrino Mixing

Models involving a U(2) flavor symmetry, or any of a number of its non-Abelian discrete subgroups, can explain the observed hierarchy of charged fermion masses and CKM angles. It is known that a large neutrino mixing angle connecting second and third generation fields may arise via the seesaw mechanism in these models, without a fine tuning of parameters. Here we show that it is possible to obtain approximate bimaximal mixing in a class of models with U(2)-like Yukawa textures. We find a minimal form for Dirac and Majorana neutrino mass matrices that leads to two large mixing angles, and show that our result can quantitatively explain atmospheric neutrino oscillations while accommodating the favored, large angle MSW solution to the solar neutrino problem. We demonstrate that these textures can arise in models by presenting a number of explicit examples.Comment: 20 pages RevTex4, 2 figure

Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture

Immortalized CWSV-1 rat hepatocytes, in which p53 protein is inactivated by SV40 large T antigen, had increased numbers of cells with strand breaks in genomic DNA (terminal dUTP end labeling) when grown in 0 μM choline (67-73% of cells) than when grown in 70 μM choline (2-3% of cells). Internucleosomal fragmentation of DNA (DNA ladders) was detected in cells grown with 5 μM and 0 μM choline for 72 h. Cells treated with 0 or 5 μM choline for 72 h detached from the substrate in high numbers (58% of choline deficient cells vs. 1.4% of choline sufficient cells detached) exhibited a high incidence of apoptosis (apoptotic bodies were seen in 55-75% of cells; 67-73% had DNA strand breaks), and an absence of mitosis and proliferating cell nuclear antigen (PCNA) expression. Cells undergoing DNA fragmentation had functioning mitochondria. At 24 h, cells grown in 0 or 5 μM choline synthesized DNA more rapidly than those grownin 70 μM choline. By 72 h, the cells grown in 0 or 5 μM choline were forming DNA much more slowly than control cells (assessed by thymidine incorporation, PCNA expression, and mitotic index). Western blot analysis showed that p53 in the nucleus of cells was detected in direct association with SV40 T-antigen, and was therefore likely to be inactive. We conclude that choline deficiency kills CWSV-1 hepatocytes in culture by inducing apoptosis via what may be a p53-independent process, and that this process begins in viable cells before they detach from the culture dish

CP Violation in a Supersymmetric SO(10) x U(2)_{F} Model

A model based on SUSY SO(10) combined with U(2) family symmetry constructed recently by the authors is generalized to include phases in the mass matrices leading to CP violation. In contrast with the commonly used effective operator approach, $\bar{126}$-dimensional Higgs fields are utilized to construct the Yukawa sector. R-parity symmetry is thus preserved at low energies. The symmetric mass textures arising from the left-right symmetry breaking chain of SO(10) give rise to very good predictions for quark and lepton masses and mixings. The prediction for $\sin 2\beta$ agrees with the average of current bounds from BaBar and Belle. In the neutrino sector, our predictions are in good agreement with results from atmospheric neutrino experiments. Our model favors both the LOW and QVO solutions to the solar neutrino anomaly; the matrix element for neutrinoless double beta decay is highly suppressed. The leptonic analog of the Jarlskog invariant, $J_{CP}^{l}$, is predicted to be of $O(10^{-2})$.Comment: RevTeX4; 7 pages; typos corrected; clarification remarks added; more references added. To appear in Physical Review

Minimal Mixing of Quarks and Leptons in the SU(3) Theory of Flavour

We argue that flavour mixing, both in the quark and lepton sector, follows the minimal mixing pattern, according to which the whole of this mixing is basically determined by the physical mass generation for the first family of fermions. So, in the chiral symmetry limit when the masses of the lightest ($u$ and $d$) quarks vanish, all the quark mixing angles vanish. This minimal pattern is shown to fit extremely well the already established CKM matrix elements and to give fairly distinctive predictions for the as yet poorly known ones. Remarkably, together with generically small quark mixing, it also leads to large neutrino mixing, provided that neutrino masses appear through the ordinary ``see-saw'' mechanism. It is natural to think that this minimal flavour mixing pattern presupposes some underlying family symmetry, treating families of quarks and leptons in a special way. Indeed, we have found a local chiral $SU(3)_{F}$ family symmetry model which leads, through its dominant symmetry breaking vacuum configuration, to a natural realization of the proposed minimal mechanism. It can also naturally generate the quark and lepton mass hierarchies. Furthermore spontaneous CP violation is possible, leading to a maximal CP violating phase $\delta =\frac{\pi}{2}$, in the framework of the MSSM extended by a high-scale $SU(3)_{F}$ chiral family symmetry.Comment: 52 pages, LaTex, no figures; some typos corrected; journal versio

Quark and Lepton Mass Matrices in the SO(10) Grand Unified Theory with Generation Flipping

We investigate the SO(10) grand unified model with generation flipping. The model contains one extra matter multiplet $\psi(10)$ and it mixes with the usual matter multiplets $\psi_i(16)$ when the SO(10) is broken down to SU(5). We find the parameter region of the model in which the observed quark masses and mixings are well reproduced. The resulting parameter region is consistent with the observation that only $\psi_i(16)$ have a source of hierarchies and indicates that the mixing between second and third generations tends to be large in the lepton sector, which is consistent with the observed maximal mixing of the atmospheric neutrino oscillation. We also show that the model can accommodate MSW and vacuum oscillation solutions to the solar neutrino deficit depending on the form of the Majorana mass matrix for the right-handed neutrinos.Comment: 28 pages, Late

A texture of neutrino mass matrix in view of recent neutrino experimental results

In view of recent neutrino experimental results such as SNO, Super-Kamiokande (SK), CHOOZ and neutrinoless double beta decay $(\beta\beta_{0\nu})$, we consider a texture of neutrino mass matrix which contains three parameters in order to explain those neutrino experimental results. We have first fitted parameters in a model independent way with solar and atmospheric neutrino mass squared differences and solar neutrino mixing angle which satisfy LMA solution. The maximal value of atmospheric neutrino mixing angle comes out naturally in the present texture. Most interestingly, fitted parameters of the neutrino mass matrix considered here also marginally satisfy recent limit on effective Majorana neutrino mass obtained from neutrinoless double beta decay experiment. We further demonstrate an explicit model which gives rise to the texture investigated by considering an $SU(2)_L\times U(1)_Y$ gauge group with two extra real scalar singlets and discrete $Z_2\times Z_3$ symmetry. Majorana neutrino masses are generated through higher dimensional operators at the scale $M$. We have estimated the scales at which singlets get VEV's and M by comparing with the best fitted results obtained in the present work.Comment: Journal Ref.: Phys. Rev. D66, 053004 (2002

Four Light Neutrinos in Singular Seesaw Mechanism with Abelian Flavor Symmetry

The four light neutrino scenario, which explains the atmosphere, solar and LSND neutrino experiments, is studied in the framework of the seesaw mechanism. By taking both the Dirac and Majorana mass matrix of neutrinos to be singular, the four neutrino mass spectrum consisting of two almost degenerate pairs separated by a mass gap $\sim 1$ eV is naturally generated. Moreover the right-handed neutrino Majorana mass can be at $\sim 10^{14}$ GeV scale unlike in the usual singular seesaw mechanism. Abelian flavor symmetry is used to produce the required neutrino mass pattern. A specific example of the flavor charge assignment is provided to show that maximal mixings between the $\nu_\mu-\nu_\tau$ and $\nu_e-\nu_s$ are respectively attributed to the atmosphere and solar neutrino anomalies while small mixing between two pairs to the LSND results. The implication in the other fermion masses is also discussed.Comment: Firnal version to appear in PR