311 research outputs found
Functionalized Poly(3-hexylthiophene)s via LithiumâBromine Exchange
Poly(3-hexylthiophene) (P3HT) is one of the most extensively investigated conjugated polymers and has been employed as the active material in many devices including field-effect transistors, organic photovoltaics and sensors. As a result, methods to further tune the properties of P3HT are desirable for specific applications. Herein, we report a facile postpolymerization modification strategy to functionalize the 4-position of commercially available P3HT in two simple stepsâbromination of the 4-position of P3HT (BrâP3HT) followed by lithiumâbromine exchange and quenching with an electrophile. We achieved near quantitative lithiumâbromine exchange with BrâP3HT, which requires over 100 thienyl lithiates to be present on a single polymer chain. The lithiated-P3HT is readily combined with functional electrophiles, resulting in P3HT derivatives with ketones, secondary alcohols, trimethylsilyl (TMS) group, fluorine, or an azide at the 4-position. We demonstrated that the azide-modified P3HT could undergo Cu-catalyzed or Cu-free click chemistry, significantly expanding the complexity of the structures that can be appended to P3HT using this method.National Science Foundation (U.S.) (ECCS-0939514
Tetrazine-Triggered Release of Carboxylic-Acid-Containing Molecules for Activation of an Anti-inflammatory Drug.
In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has emerged as a promising strategy to enable protein or drug activation in a spatially and temporally controlled manner. This study demonstrates the application of a bioorthogonal inverse electron-demand Diels-Alder (iEDDA) reaction to cleave trans-cyclooctene (TCO) and vinyl protecting groups from carboxylic acid-containing molecules. The tetrazine-mediated decaging reaction proceeded under biocompatible conditions with fast reaction kinetics (<2â
min). The anti-inflammatory activity of ketoprofen was successfully reinstated after decaging of the nontoxic TCOprodrug in live macrophages. Overall, this work expands the scope of functional groups and the application of decaging reactions to a new class of drugs
Macroporous polymer supported azide and nanocopper (I): efficient and reusable reagent and catalyst for multicomponent click synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from benzyl halides
The potential of bioorthogonal chemistry for correlative light and electron microscopy: a call to arms
Bio-organic Synthesi
A mobile hospice nurse teaching teamâs experience: training care workers in spiritual and existential care for the dying - a qualitative study
Metal-Free Functionalization of Linear Polyurethanes by Thiol-Maleimide Coupling Reactions
The challenge of consolation: nursesâ experiences with spiritual and existential care for the dying-a phenomenological hermeneutical study
Use of ring-expanded diamino- and diamidocarbene ligands in copper catalyzed azide-alkyne "click" reactions
The
two-coordinate ring-expanded N-heterocyclic carbene copperÂ(I)
complexes [CuÂ(RE-NHC)<sub>2</sub>]<sup>+</sup> (RE-NHC = 6-Mes, 7-<i>o</i>-Tol, 7-Mes) have been prepared and shown to be effective
catalysts under neat conditions for the 1,3-dipolar cycloaddition
of alkynes and azides. In contrast, the cationic diamidocarbene analogue
[CuÂ(6-MesDAC)<sub>2</sub>]<sup>+</sup> and the neutral species [(6-MesDAC)ÂCuCl]<sub>2</sub> and [(6-MesDAC)<sub>2</sub>(CuCl)<sub>3</sub>] show good
activity when the catalysis is performed on water
Improved non-covalent biofunctionalization of multi-walled carbon nanotubes using carbohydrate amphiphiles with a butterfly-like polyaromatic tail
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