Interactions of the Intestinal Epithelium with the Pathogen and the Indigenous Microbiota: A Three-Way Crosstalk

The mucosal surfaces of the gastrointestinal tract harbor a vast number of commensal microbiota that have coevolved with the host, and in addition display one of the most complex relationships with the host. This relationship affects several important aspects of the biology of the host including the synthesis of nutrients, protection against infection, and the development of the immune system. On the other hand, despite the existence of several lines of mucosal defense mechanisms, pathogenic organisms such as Shigella and Salmonella have evolved sophisticated virulence strategies for breaching these barriers. The constant challenge from these pathogens and the attempts by the host to counter them set up a dynamic equilibrium of cellular and molecular crosstalk. Even slight perturbations in this equilibrium may be detrimental to the host leading to severe bacterial infection or even autoimmune diseases like inflammatory bowel disease. Several experimental model systems, including germ-free mice and antibiotic-treated mice, have been used by various researchers to study this complex relationship. Although it is only the beginning, it promises to be an exciting era in the study of these host-microbe relationships

Knowledge, attitude, practice of rational use of medicines among junior residents in a tertiary care hospital

Background: Irrational use of prescribing is on the rise due to many factors like false beliefs, following a prescribing pattern of senior doctors, inadequate knowledge, ignorance, promotional activities for the profit of professionals by pharmaceutical industry and lack of enforcement of regulations by regulatory authorities. Junior residents are exposed to variety of prescribing patterns in the first year and are the future physicians and specialists. There are very few studies among JRs, hence the present study was conducted to assess the knowledge, attitude and practice of junior residents about rational use of medicines.Methods: This was a cross-sectional, questionnaire based study conducted among JRs at a tertiary care hospital in South India in June 2015. The participants were explained about the study and consent was taken. Permission was obtained from institutional ethics committee. Identity of the residents was kept confidential. A self-developed, pre-validated, semi-structured questionnaire consisting of both open-ended and closed-ended items was used. Questionnaire was designed to obtain information about the knowledge, attitude and practice of RUM. The data was recorded and analyzed using Microsoft Excel (2013 version) and the results are explained in frequency and percentage.Results: The knowledge related to essential medicines list (EML), P drugs and schedule H drugs was limited. Participants had limited knowledge about the revision of EML list, number of fixed dose combinations (FDCs)in EML, STEP criteria for choosing a P drug and advantages of choosing a P drug Most of the JRs frequently prescribed drugs from EML. Trade name and newer drugs were prescribed around 50%. The prescription of FDCs from EML was very low (6%). Around 50% of JRs prescribe medicines with both generic and brand name.Conclusions: Majority of JRs were aware about various issues concerned with RUM but the knowledge related to EML, P drugs, schedule H drugs and number of FDCs in EML was limited.  As junior residents are future prescribers, they need to be aware of all the aspects of RUM. Inadequate/improper knowledge in the above areas is a matter of concern and needs to be addressed

Lime-Stabilized Black Cotton Soil and Brick Powder Mixture as Subbase Material

Various researchers, for the past few decades, had tried to stabilize black cotton soil using lime for improving its shrinkage and swelling characteristics. But these days, the cost of lime has increased resulting in increase in need for alternative and cost effective waste materials such as fly ash and rice husk ash. Brick powder, one among the alternative materials, is a fine powdered waste that contains higher proportions of silica and is found near brick kilns in rural areas. The objective of the study is to investigate the use of lime-stabilized black cotton soil and brick powder mixture as subbase material in flexible pavements. Black cotton soil procured from the local area, tested for suitability as subbase material, turned out to be unsuitable as it resulted in very less CBR value. Even lime stabilization of black cotton soil under study has not showed up the required CBR value specified for the subbase material of flexible pavement by MORTH. Hence the lime-stabilized black cotton soil is proportioned with brick powder to obtain optimum mixture that yields a better CBR value. The mixture of 20% brick powder and 80% lime-stabilized black cotton soil under study resulted in increase in the CBR value by about 135% in comparison with lime-stabilized black cotton soil. Thus it is promising to use the mixture of brick powder and lime-stabilized black cotton soil as subbase material in flexible pavements

Quantumness of noisy quantum walks: a comparison between measurement-induced disturbance and quantum discord

Noisy quantum walks are studied from the perspective of comparing their quantumness as defined by two popular measures, measurement-induced disturbance (MID) and quantum discord (QD). While the former has an operational definition, unlike the latter, it also tends to overestimate non-classicality because of a lack of optimization over local measurements. Applied to quantum walks, we find that MID, while acting as a loose upper bound on QD, still tends to reflect correctly the trends in the behavior of the latter. However, there are regimes where its behavior is not indicative of non-classicality: in particular, we find an instance where MID increases with the application of noise, where we expect a reduction of quantumness.Comment: 5 pages with 4 figures, Published Versio

Differentiating between Hemorrhagic Infarct and Parenchymal Intracerebral Hemorrhage

Differentiating hemorrhagic infarct from parenchymal intracerebral hemorrhage can be difficult. The immediate and long-term management of the two conditions are different and hence the importance of accurate diagnosis. Using a series of intracerebral hemorrhage cases presented to our stroke unit, we aim to highlight the clues that may be helpful in distinguishing the two entities. The main clue to the presence of hemorrhagic infarct on computed tomography scan is the topographic distribution of the stroke. Additional imaging modalities such as computed tomography angiogram, perfusion, and magnetic resonance imaging may provide additional information in differentiating hemorrhagic infarct from primary hemorrhages

АСР процесса горения твердого композиционного топлива при безмазутной растопке парового котла

ВКР предполагает разработку комплекта проектной и конструкторской документации для создания АСР процесса горения твердого композиционного топлива при безмазутной растопке парового котла.The WRC involves the development of a set of design and construction documentation for the creation of an ACR for the combustion of solid composite fuel with oil-free kindling of a steam boiler

An Integrated Routing and Rate Adaptation Framework for Multi-rate Multi-hop Wireless Networks

International audienceIn this paper, we propose a new integrated framework for joint routing and rate adaptation in multi-rate multi-hop wireless networks. Unlike many previous efforts, our framework considers several factors that affect end-to-end performance. Among these factors, the framework takes into account the effect of the relative positions of the links on a path when choosing the rates of operation and the importance of avoiding congested areas. The key element of our framework is a new comprehensive path metric that we call ETM (for expected transmission cost in multi-rate wireless networks). We analytically derive the ETM metric. We show that the ETM metric can be used to determine the best end-to-end path with a greedy routing approach. We also show that the metric can be used to dynamically select the best transmission rate for each link on the path via a dynamic programming approach. We implement the ETM-framework on an indoor wireless mesh network and compare its performance with that of frameworks based on the popular ETT and the recently proposed ETOP metrics. Our experiments demonstrate that the ETM-framework can yield throughput improvements of up to 253 and 368 % as compared with the ETT and ETOP frameworks

Blood pressure, aortic stiffness, hemodynamics and cognition in twin pairs discordant for type 2 diabetes

Background: Type 2 diabetes (T2D) is associated with an increased risk of cognitive impairment and dementia with poorly understood underlying mechanisms. Objective: We examined the role of blood pressure (BP), aortic stiffness, and hemodynamics in this association. Methods: Cross-sectional sample of late middle-aged twins discordant for T2D from the Australian Twin Registry. Measurements included neuropsychological battery and brain MRI including arterial spin labelling (ASL) to measure cerebral perfusion. Mobil-o-Graph devices were used to non-invasively obtain 24-hour BP, aortic stiffness, and hemodynamic measures. Using mixed modelling, we studied associations of T2D with cognition, MRI measures, BP, aortic stiffness, and hemodynamics. Results: There were 23 twin pairs with mean age 63.7 (SD = 6.1) years. T2D (β=-0.45, p < 0.001) and age (β=-0.05, p = 0.022) were independently associated with poorer attention but not with memory or perceptual speed. T2D was associated with reduced nocturnal central systolic BP dipping (β=-3.79, p = 0.027), but not with BP, aortic stiffness, cerebral perfusion, or other hemodynamic measures. There was a statistically significant interaction between T2D and central systolic BP dipping in predicting attention scores (both p < 0.05 for the interaction term) whereby there was a positive association between BP dipping and attention scores in those with T2D, but not in those without T2D. Conclusion: We found an association between T2D and reduced nocturnal central systolic dipping, but not with any other measures of BP, stiffness or hemodynamic measures. Further study of the role of nocturnal central BP dipping in the association between T2D and cognitive impairment may help identify potential mechanisms