361 research outputs found
The transmission of nosocomial pathogens in an intensive care unit: a space–time clustering and structural equation modelling approach
We investigated the incidence of cases of nosocomial pathogens and risk factors in an intensive treatment unit ward to determine if the number of cases is dependent on location of patients and the colonization/infection history of the ward. A clustering approach method was developed to investigate the patterns of spread of cases through time for five microorganisms [methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter spp., Klebsiella spp., Candida spp., and Pseudomonas aeruginosa] using hospital microbiological monitoring data and ward records of patient-bed use. Cases of colonization/infection by MRSA, Candida and Pseudomonas were clustered in beds and through time while cases of Klebsiella and Acinetobacter were not. We used structural equation modelling to analyse interacting risk factors and the potential pathways of transmission in the ward. Prior nurse contact with colonized/infected patients, mediated by the number of patient-bed movements, were important predictors for all cases, except for those of Pseudomonas. General health and invasive surgery were significant predictors of cases of Candida and Klebsiella. We suggest that isolation and bed movement as a strategy to manage MRSA infections is likely to impact upon the incidence of cases of other opportunist pathogen
'This is what is going to help me': Developing a co-designed and theoretically informed harm reduction intervention for mobile youth in South Africa and Uganda
Young migrants in sub-Saharan Africa are particularly vulnerable to HIV-acquisition. Despite this, they are consistently under-served by services, with low uptake and engagement. We adopted a community-based participatory research approach to conduct longitudinal qualitative research among 78 young migrants in South Africa and Uganda. Using repeat in-depth interviews and participatory workshops we sought to identify their specific support needs, and to collaboratively design an intervention appropriate for delivery in their local contexts. Applying a protection-risk conceptual framework, we developed a harm reduction intervention which aims to foster protective factors, and thereby nurture resilience, for youth ‘on the move’ within high-risk settings. Specifically, by establishing peer supporter networks, offering a ‘drop-in’ resource centre, and by identifying local adult champions to enable a supportive local environment. Creating this supportive edifice, through an accessible and cohesive peer support network underpinned by effective training, supervision and remuneration, was considered pivotal to nurture solidarity and potentially resilience. This practical example offers insights into how researchers may facilitate the co-design of acceptable, sustainable interventions
Adding control to arbitrary unknown quantum operations
While quantum computers promise significant advantages, the complexity of
quantum algorithms remains a major technological obstacle. We have developed
and demonstrated an architecture-independent technique that simplifies adding
control qubits to arbitrary quantum operations-a requirement in many quantum
algorithms, simulations and metrology. The technique is independent of how the
operation is done, does not require knowledge of what the operation is, and
largely separates the problems of how to implement a quantum operation in the
laboratory and how to add a control. We demonstrate an entanglement-based
version in a photonic system, realizing a range of different two-qubit gates
with high fidelity.Comment: 9 pages, 8 figure
Experimental demonstration of a hyper-entangled ten-qubit Schr\"odinger cat state
Coherent manipulation of an increasing number of qubits for the generation of
entangled states has been an important goal and benchmark in the emerging field
of quantum information science. The multiparticle entangled states serve as
physical resources for measurement-based quantum computing and high-precision
quantum metrology. However, their experimental preparation has proved extremely
challenging. To date, entangled states up to six, eight atoms, or six photonic
qubits have been demonstrated. Here, by exploiting both the photons'
polarization and momentum degrees of freedom, we report the creation of
hyper-entangled six-, eight-, and ten-qubit Schr\"odinger cat states. We
characterize the cat states by evaluating their fidelities and detecting the
presence of genuine multi-partite entanglement. Small modifications of the
experimental setup will allow the generation of various graph states up to ten
qubits. Our method provides a shortcut to expand the effective Hilbert space,
opening up interesting applications such as quantum-enhanced super-resolving
phase measurement, graph-state generation for anyonic simulation and
topological error correction, and novel tests of nonlocality with
hyper-entanglement.Comment: 11 pages, 5 figures, comments welcom
Heralded generation of entangled photon pairs
Entangled photons are a crucial resource for quantum communication and linear
optical quantum computation. Unfortunately, the applicability of many
photon-based schemes is limited due to the stochastic character of the photon
sources. Therefore, a worldwide effort has focused in overcoming the limitation
of probabilistic emission by generating two-photon entangled states conditioned
on the detection of auxiliary photons. Here we present the first heralded
generation of photon states that are maximally entangled in polarization with
linear optics and standard photon detection from spontaneous parametric
down-conversion. We utilize the down-conversion state corresponding to the
generation of three photon pairs, where the coincident detection of four
auxiliary photons unambiguously heralds the successful preparation of the
entangled state. This controlled generation of entangled photon states is a
significant step towards the applicability of a linear optics quantum network,
in particular for entanglement swapping, quantum teleportation, quantum
cryptography and scalable approaches towards photonics-based quantum computing
Resonant enhancement of the zero-phonon emission from a color center in a diamond cavity
We demonstrate coupling of the zero-phonon line of individual
nitrogen-vacancy centers and the modes of microring resonators fabricated in
single-crystal diamond. A zero-phonon line enhancement exceeding ten-fold is
estimated from lifetime measurements at cryogenic temperatures. The devices are
fabricated using standard semiconductor techniques and off-the-shelf materials,
thus enabling integrated diamond photonics.Comment: 5 pages, 4 figure
Operational Significance of Discord Consumption: Theory and Experiment
Coherent interactions that generate negligible entanglement can still exhibit
unique quantum behaviour. This observation has motivated a search beyond
entanglement for a complete description of all quantum correlations. Quantum
discord is a promising candidate. Here, we demonstrate that under certain
measurement constraints, discord between bipartite systems can be consumed to
encode information that can only be accessed by coherent quantum interactions.
The inability to access this information by any other means allows us to use
discord to directly quantify this `quantum advantage'. We experimentally encode
information within the discordant correlations of two separable Gaussian
states. The amount of extra information recovered by coherent interaction is
quantified and directly linked with the discord consumed during encoding. No
entanglement exists at any point of this experiment. Thus we introduce and
demonstrate an operational method to use discord as a physical resource.Comment: 10 pages, 3 figures, updated with Nature Physics Reference,
simplified proof in Appendi
Quantum heuristic algorithm for traveling salesman problem
We propose a quantum heuristic algorithm to solve a traveling salesman
problem by generalizing Grover search. Sufficient conditions are derived to
greatly enhance the probability of finding the tours with extremal costs,
reaching almost to unity and they are shown characterized by statistical
properties of tour costs. In particular for a Gaussian distribution of the
tours along the cost we show that the quantum algorithm exhibits the quadratic
speedup of its classical counterpart, similarly to Grover search.Comment: Published versio
Quantum simulation of the wavefunction to probe frustrated Heisenberg spin systems
Quantum simulators are controllable quantum systems that can reproduce the
dynamics of the system of interest, which are unfeasible for classical
computers. Recent developments in quantum technology enable the precise control
of individual quantum particles as required for studying complex quantum
systems. Particularly, quantum simulators capable of simulating frustrated
Heisenberg spin systems provide platforms for understanding exotic matter such
as high-temperature superconductors. Here we report the analog quantum
simulation of the ground-state wavefunction to probe arbitrary Heisenberg-type
interactions among four spin-1/2 particles . Depending on the interaction
strength, frustration within the system emerges such that the ground state
evolves from a localized to a resonating valence-bond state. This spin-1/2
tetramer is created using the polarization states of four photons. The
single-particle addressability and tunable measurement-induced interactions
provide us insights into entanglement dynamics among individual particles. We
directly extract ground-state energies and pair-wise quantum correlations to
observe the monogamy of entanglement
Development of the preterm gut microbiome in twins at risk of necrotising enterocolitis and sepsis
The preterm gut microbiome is a complex dynamic community influenced by genetic and environmental factors and is implicated in the pathogenesis of necrotising enterocolitis (NEC) and sepsis. We aimed to explore the longitudinal development of the gut microbiome in preterm twins to determine how shared environmental and genetic factors may influence temporal changes and compared this to the expressed breast milk (EBM) microbiome. Stool samples (n = 173) from 27 infants (12 twin pairs and 1 triplet set) and EBM (n = 18) from 4 mothers were collected longitudinally. All samples underwent PCR-DGGE (denaturing gradient gel electrophoresis) analysis and a selected subset underwent 454 pyrosequencing. Stool and EBM shared a core microbiome dominated by Enterobacteriaceae, Enterococcaceae, and Staphylococcaceae. The gut microbiome showed greater similarity between siblings compared to unrelated individuals. Pyrosequencing revealed a reduction in diversity and increasing dominance of Escherichia sp. preceding NEC that was not observed in the healthy twin. Antibiotic treatment had a substantial effect on the gut microbiome, reducing Escherichia sp. and increasing other Enterobacteriaceae.
This study demonstrates related preterm twins share similar gut microbiome development, even within the complex environment of neonatal intensive care. This is likely a result of shared genetic and immunomodulatory factors as well as exposure to the same maternal microbiome during birth, skin contact and exposure to EBM. Environmental factors including antibiotic exposure and feeding are additional significant determinants of community structure, regardless of host genetics
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