First Evidence of a HIV-1 M/O Recombinant Form Circulating Outside Cameroon

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Travelers With Cutaneous Leishmaniasis Cured Without Systemic Therapy

Guidelines recommend wound care and/or local therapy as first-line treatment for cutaneous leishmaniasis. An analysis of a referral treatment program in 135 travelers showed that this approach was feasible in 62% of patients, with positive outcome in 83% of evaluable patient

Simple scoring system to predict in-hospital mortality after surgery for infective endocarditis

BACKGROUND: Aspecific scoring systems are used to predict the risk of death postsurgery in patients with infective endocarditis (IE). The purpose of the present study was both to analyze the risk factors for in-hospital death, which complicates surgery for IE, and to create a mortality risk score based on the results of this analysis. METHODS AND RESULTS: Outcomes of 361 consecutive patients (mean age, 59.1\ub115.4 years) who had undergone surgery for IE in 8 European centers of cardiac surgery were recorded prospectively, and a risk factor analysis (multivariable logistic regression) for in-hospital death was performed. The discriminatory power of a new predictive scoring system was assessed with the receiver operating characteristic curve analysis. Score validation procedures were carried out. Fifty-six (15.5%) patients died postsurgery. BMI >27 kg/m2 (odds ratio [OR], 1.79; P=0.049), estimated glomerular filtration rate 55 mm Hg (OR, 1.78; P=0.032), and critical state (OR, 2.37; P=0.017) were independent predictors of in-hospital death. A scoring system was devised to predict in-hospital death postsurgery for IE (area under the receiver operating characteristic curve, 0.780; 95% CI, 0.734-0.822). The score performed better than 5 of 6 scoring systems for in-hospital death after cardiac surgery that were considered. CONCLUSIONS: A simple scoring system based on risk factors for in-hospital death was specifically created to predict mortality risk postsurgery in patients with IE

Management and prevention of imported malaria. 2018 update of the 2007 French clinical guidelines

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Opacités pulmonaires multiples révélant une toxocarose

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Nouveau modèle analytique pour une meilleure estimation des flux nets annuels en métaux dissous. Cas du cadmium dans l’estuaire de la Gironde

International audienceNouveau modèle analytique pour une meilleure estimation des flux nets annuels en métaux dissous. Cas du cadmium dans l'estuaire de la Gironde New computation for a better estimation of the annual dissolved metal net fluxes. The case of the cadmium in the Gironde estuar

Les rougeoles de l’adulte hospitalisé, en France, au xxie siècle

International audienceBackgroundAn epidemic of measles broke out in France in 2008. We designed a retrospective study focusing on adults hospitalized for measles in 2010/2011.MethodsA case was any patient aged more than 15 years, hospitalized (September 2010 to September 2011) with a typical rash or a biological diagnosis. Data was collected with standardized questionnaires in participating hospitals.ResultsFour hundred and sixty cases were reported: sex-ratio (M/F) = 0.93, median age 26 years (σ = 8.8). Twenty-nine cases were severe (6.5%), 27 of which hospitalized in an ICU. Three hundred and twelve (68%) cases had elevated serum transaminases (EST), 155 (34%) cases had pneumonia, 34 (7%) cases had elevated serum creatinin (ESC), four (0.9%) cases had elevated serum amylase and lipase (ESAL), and three (0.7%) cases had neurological symptoms. One hundred and four (23%) patients presented simultaneously with EST and pneumonia. One patient presenting with severe pneumonia died (0.2%). One hundred and ten (24%) patients received antibiotics during a median seven days.ConclusionMeasles can present as various syndromes in adults and be responsible for a high burden during outbreaks. The immediate outcome is favorable in most patients. Long-term outcome needs further investigations to identify possible late complications.ContexteUne épidémie de rougeole est survenue en France, de 2008 à 2011. Nous avons mené une étude rétrospective, sur les adultes hospitalisés pour rougeole.MéthodesUn cas était un patient âgé de plus de 15 ans, hospitalisé (septembre 2010 à septembre 2011) présentant un rash typique ou un diagnostique biologique. Les données ont été recueillies grâce à un questionnaire standardisé, dans les centres hospitaliers participants.RésultatsQuatre cent soixante cas ont été recueillis: sex-ratio (M/F) = 0,93, âge médian 26 ans (σ = 8,8). Vingt-neuf cas ont été graves (6,5 %), dont 27 hospitalisés en soins intensifs. 312 (68 %) cas ont présenté des transaminases sériques élevées, 155 (34 %) cas ont présenté une pneumonie, 34 (7 %) cas avaient une créatininémie élevée, quatre (0,9 %) cas avaient des amylasémies et lipasémies élevées, et trois (0,7 %) cas avaient des symptômes neurologiques. Cent quatre (23 %) patients ont présenté simultanément des transaminases élevées et une pneumonie. Une patiente avec une pneumonie grave est décédée (0,2 %). Cent dix (24 %) patients ont reçu une antibiothérapie pendant une durée médiane de sept jours.ConclusionLa rougeole de l’adulte peut se présenter sous des formes cliniques variées et peut être un important fardeau de santé publique en cas d’épidémie. Le pronostic immédiat est favorable chez la plupart des patients. Un suivi à long terme est cependant nécessaire afin d’identifier de possibles complications tardives

Software Safety Supervision On-board Autonomous Spacecraft

International audienceThis paper presents a study on software product assurance measures and dependability techniques to support autonomous functions on-board spacecraft. An analysis of current standards and techniques in space and other domains, and a survey of software autonomy projects from the point of view of product assurance, dependability and safety are presented. Product assurance measures are proposed, and the paper concludes with the description of two generic software components that have been developed and experimented to provide additional safety mechanisms in autonomous space systems: a "safety bag" in charge of monitoring on-board a set of safety properties, and a "plausibility checker" complementing on ground the validation means for interpreted procedures before they are uploaded and executed on-board