NMR Spectroscopy: A Useful Tool in the Determination of the Electrophilic Character of Benzofuroxans - Case Examples of the Reactions of Nitrobenzofuroxans with Dienes and Nucleophiles

International audienc

Betatron emission as a diagnostic for injection and acceleration mechanisms in laser-plasma accelerators

Betatron x-ray emission in laser-plasma accelerators is a promising compact source that may be an alternative to conventional x-ray sources, based on large scale machines. In addition to its potential as a source, precise measurements of betatron emission can reveal crucial information about relativistic laser-plasma interaction. We show that the emission length and the position of the x-ray emission can be obtained by placing an aperture mask close to the source, and by measuring the beam profile of the betatron x-ray radiation far from the aperture mask. The position of the x-ray emission gives information on plasma wave breaking and hence on the laser non-linear propagation. Moreover, the measurement of the longitudinal extension helps one to determine whether the acceleration is limited by pump depletion or dephasing effects. In the case of multiple injections, it is used to retrieve unambiguously the position in the plasma of each injection. This technique is also used to study how, in a capillary discharge, the variations of the delay between the discharge and the laser pulse affect the interaction. The study reveals that, for a delay appropriate for laser guiding, the x-ray emission only occurs in the second half of the capillary: no electrons are injected and accelerated in the first half.Comment: 8 pages, 6 figures. arXiv admin note: text overlap with arXiv:1104.245

Single shot phase contrast imaging using laser-produced Betatron x-ray beams

Development of x-ray phase contrast imaging applications with a laboratory scale source have been limited by the long exposure time needed to obtain one image. We demonstrate, using the Betatron x-ray radiation produced when electrons are accelerated and wiggled in the laser-wakefield cavity, that a high quality phase contrast image of a complex object (here, a bee), located in air, can be obtained with a single laser shot. The Betatron x-ray source used in this proof of principle experiment has a source diameter of 1.7 microns and produces a synchrotron spectrum with critical energy E_c=12.3 +- 2.5 keV and 10^9 photons per shot in the whole spectrum.Comment: 3 pages, 3 figure

Demonstration of the synchrotron-type spectrum of laser-produced Betatron radiation

Betatron X-ray radiation in laser-plasma accelerators is produced when electrons are accelerated and wiggled in the laser-wakefield cavity. This femtosecond source, producing intense X-ray beams in the multi kiloelectronvolt range has been observed at different interaction regime using high power laser from 10 to 100 TW. However, none of the spectral measurement performed were at sufficient resolution, bandwidth and signal to noise ratio to precisely determine the shape of spectra with a single laser shot in order to avoid shot to shot fluctuations. In this letter, the Betatron radiation produced using a 80 TW laser is characterized by using a single photon counting method. We measure in single shot spectra from 8 to 21 keV with a resolution better than 350 eV. The results obtained are in excellent agreement with theoretical predictions and demonstrate the synchrotron type nature of this radiation mechanism. The critical energy is found to be Ec = 5.6 \pm 1 keV for our experimental conditions. In addition, the features of the source at this energy range open novel perspectives for applications in time-resolved X-ray science.Comment: 5 pages, 4 figure

Monotherapy with pixantrone in histologically confirmed relapsed or refractory aggressive B-cell non-Hodgkin lymphoma: post-hoc analyses from a phase III trial.

This post hoc analysis of a phase 3 trial explored the effect of pixantrone in patients (50 pixantrone, 47 comparator) with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (NHL) confirmed by centralized histological review. Patients received 28-d cycles of 85 mg/m(2) pixantrone dimaleate (equivalent to 50 mg/m(2) in the approved formulation) on days 1, 8 and 15, or comparator. The population was subdivided according to previous rituximab use and whether they received the study treatment as 3rd or 4th line. Median number of cycles was 4 (range, 2-6) with pixantrone and 3 (2-6) with comparator. In 3rd or 4th line, pixantrone was associated with higher complete response (CR) (23·1% vs. 5·1% comparator, P = 0·047) and overall response rate (ORR, 43·6% vs. 12·8%, P = 0·005). In 3rd or 4th line with previous rituximab (20 pixantrone, 18 comparator), pixantrone produced better ORR (45·0% vs. 11·1%, P = 0·033), CR (30·0% vs. 5·6%, P = 0·093) and progression-free survival (median 5·4 vs. 2·8 months, hazard ratio 0·52, 95% confidence interval 0·26-1·04) than the comparator. Similar results were found in patients without previous rituximab. There were no unexpected safety issues. Pixantrone monotherapy is more effective than comparator in relapsed or refractory aggressive B-cell NHL in the 3rd or 4th line setting, independently of previous rituximab

All-optical Compton gamma-ray source

International audienceOne of the major goals of research for laser-plasma accelerators (1) is the realization of compact sources of femtosecond X-rays (2, 3, 4). In particular, using the modest electron energies obtained with existing laser systems, Compton scattering a photon beam off a relativistic electron bunch has been proposed as a source of high-energy and high-brightness photons. However, laser-plasma based approaches to Compton scattering have not, to date, produced X-rays above 1 keV. Here, we present a simple and compact scheme for a Compton source based on the combination of a laser-plasma accelerator and a plasma mirror. This approach is used to produce a broadband spectrum of X-rays extending up to hundreds of keV and with a 10,000-fold increase in brightness over Compton X-ray sources based on conventional accelerators (5, 6). We anticipate that this technique will lead to compact, high-repetition-rate sources of ultrafast (femtosecond), tunable (X- through gamma-ray) and low-divergence (~1°) photons from source sizes on the order of a micrometre