Using bijective maps to improve free energy estimates

We derive a fluctuation theorem for generalized work distributions, related to bijective mappings of the phase spaces of two physical systems, and use it to derive a two-sided constraint maximum likelihood estimator of their free energy difference which uses samples from the equilibrium configurations of both systems. As an application, we evaluate the chemical potential of a dense Lennard-Jones fluid and study the construction and performance of suitable maps.Comment: 17 pages, 11 figure

Histopathological Study of Stomatitis Nicotina

One hundred and thirteen biopsies of the palate in people accustomed to smoking cigars, most of them with the burning end of the cigar inside the mouth, have been studied

Changes in the ducts of the glands of the hard palate in reverse smokers

Three hundred fifty-nine cases of stomatitis nicotina were studied in reverse smokers of home made chuttas. One hundred thirty-five biopsies of papular unbilicated lesions of stomatitis nicotina were studied histopathologically. The biopsies were chosen after toluidine blue staining. Mild dysplastic to severe dysplastic changes were seen around the openings of the ducts of the glands. There were three cases of microinvasive carcinoma in the one hundred thirty-five biopsies. Cystic dilatation of the ducts, due to obstruction of the ducts by keratotic plugging, was not seen in stomatitis nicotina lesions but was seen in elderly women who had smoked reverse for more than 4 to 5 decades. The ducts of the glands could probably form a portal of entry for the tobacco pyrolytic products which may act as carcinogenics

Integrated care and the working record

By default, many discussions and specifications of electronic health records or integrated care records often conceptualize the record as a passive information repository. This article presents data from a case study of work in a medical unit in a major metropolitan hospital. It shows how the clinicians tailored, re-presented and augmented clinical information to support their own roles in the delivery of care for individual patients. This is referred to as the working record: a set of complexly interrelated clinician-centred documents that are locally evolved, maintained and used to support delivery of care in conjunction with the more patient-centred chart that will be stored in the medical records department on the patient’s discharge. Implications are drawn for how an integrated care record could support the local tailorability and flexibility that underpin this working record and hence underpin practice

The dynamics and control of large flexible space structures, part 7

A preliminary Eulerian formulation of the in-plane dynamics of the proposed spacecraft control laboratory experiment configuration is undertaken when the mast is treated as a cantilever type beam and the reflector as a lumped mass at the end of the beam. Frequency and mode shapes are obtained for the open loop model of the beam system and the stability of closed loop control systems is analyzed by both frequency and time domain techniques. Environmental disturbances due to solar radiation pressure are incorporated into models of controlled large flexible orbiting platforms. Thermally induced deformations of simple beam and platform type structures are modelled and expressions developed for the disturbance torques resulting from the interaction of solar radiation pressure. Noise effects in the deterministic model of the hoop/column antenna system are found to cause a degradation in system performance. Appropriate changes in the ratio of plant noise to the measurement noise and/or changes in the control weighting matrix elements can improve transient and steady state performance

Acute guinea-worm synovitis of the knee joint

Fourteen cases of acute guinea worm synovitis are described. The complete clinical picture, diagnosis, treatment, and follow-up are presented. That the guinea worm can cause a specific type of synovitis and that the causation of the synovitis is chemical in nature are demonstrated

The dynamics and control of large flexible space structures, 8

A development of the in plane open loop rotational equations of motion for the proposed Spacecraft Control Laboratory Experiment (SCOLE) in orbit configuration is presented based on an Eulerian formulation. The mast is considered to be a flexible beam connected to the (rigid) shuttle and the reflector. Frequencies and mode shapes are obtained for the mast vibrational appendage modes (assumed to be decoupled) for different boundary conditions based on continuum approaches and also preliminary results are obtained using a finite element representation of the mast reflector system. The linearized rotational in plane equation is characterized by periodic coefficients and open loop system stability can be examined with an application of the Floquet theorem. Numerical results are presented to illustrate the potential instability associated with actuator time delays even for delays which represent only a small fraction of the natural period of oscillation of the modes contained in the open loop model of the system. When plant and measurement noise effects are added to the previously designed deterministic model of the hoop column system, it is seen that both the system transient and steady state performance are degraded. Mission requirements can be satisfied by appropriate assignment of cost function weighting elements and changes in the ratio of plant noise to measurement noise

Nicotine stomatitis and its relation to carcinoma of the hard palate in reverse smokers of chuttas

Clinical surveys and biopsy studies demonstrated a close correlation among reverse smoking, nicotine stomatitis, and carcinoma of the palate

Giant-cell tumors of bone in South India

Giant-cell tumors of bone are rare or uncommon. Dodge reported that giant-cell tumor is rare in Ugandan Africans, but Hadley and associates and Rockwell and Small noted that giant-cell tumor of bone is comparatively common in South India. In this paper we give an account of the general prevalence of giant-cell tumors of bone in our part of South India