Effects of lattice distortion and Jahn–Teller coupling on the magnetoresistance of La0.7Ca0.3MnO3 and La0.5Ca0.5CoO3 epitaxial films

Studies of La0.7Ca0.3MnO3 epitaxial films on substrates with a range of lattice constants reveal two dominant contributions to the occurrence of colossal negative magnetoresistance (CMR) in these manganites: at high temperatures (T → TC, TC being the Curie temperature), the magnetotransport properties are predominantly determined by the conduction of lattice polarons, while at low temperatures (T ≪ TC/, the residual negative magnetoresistance is correlated with the substrate-induced lattice distortion which incurs excess magnetic domain wall scattering. The importance of lattice polaron conduction associated with the presence of Jahn–Teller coupling in the manganites is further verified by comparing the manganites with epitaxial films of another ferromagnetic perovskite, La0.5Ca0.5CoO3. Regardless of the differences in the substrate-induced lattice distortion, the cobaltite films exhibit much smaller negative magnetoresistance, which may be attributed to the absence of Jahn–Teller coupling and the high electron mobility that prevents the formation of lattice polarons. We therefore suggest that lattice polaron conduction associated with the Jahn–Teller coupling is essential for the occurrence of CMR, and that lattice distortion further enhances the CMR effects in the manganites

Stability Analysis of Numerical Boundary Conditions and Implicit Difference Approximations for Hyperbolic Equations

Implicit noniterative finite-difference schemes have recently been developed by several authors for multidimensional systems of nonlinear hyperbolic partial differential equations. When applied to linear model equations with periodic boundary conditions those schemes are unconditionally stable (A-stable). As applied in practice the algorithms often face a severe time-step restriction. A major source of the difficulty is the treatment of the numerical boundary conditions. One conjecture has been that unconditional stability requires implicit numerical boundary conditions. An apparent counterexample was the space-time extrapolation considered by Gustafsson, Kreiss, and Sundstrom. In this paper we examine space (implicit) and space-time (explicit) extrapolation using normal mode analysis for a finite and infinite number of spatial mesh intervals. The results indicate that for unconditional stability with a finite number of spatial mesh intervals the numerical boundary conditions must be implicit

The acceleration and storage of radioactive ions for a neutrino factory

The term beta-beam has been coined for the production of a pure beam of electron neutrinos or their antiparticles through the decay of radioactive ions circulating in a storage ring. This concept requires radioactive ions to be accelerated to a Lorentz gamma of 150 for 6He and 60 for 18Ne. The neutrino source itself consists of a storage ring for this energy range, with long straight sections in line with the experiment(s). Such a decay ring does not exist at CERN today, nor does a high-intensity proton source for the production of the radioactive ions. Nevertheless, the existing CERN accelerator infrastructure could be used as this would still represent an important saving for a beta-beam facility. This paper outlines the first study, while some of the more speculative ideas will need further investigations.Comment: Accepted for publication in proceedings of Nufact02, London, 200

Gene-environment interplay in depressive symptoms:Moderation by age, sex, and physical illness

BackgroundNumerous factors influence late-life depressive symptoms in adults, many not thoroughly characterized. We addressed whether genetic and environmental influences on depressive symptoms differed by age, sex, and physical illness.MethodThe analysis sample included 24 436 twins aged 40–90 years drawn from the Interplay of Genes and Environment across Multiple Studies (IGEMS) Consortium. Biometric analyses tested age, sex, and physical illness moderation of genetic and environmental variance in depressive symptoms.ResultsWomen reported greater depressive symptoms than men. After age 60, there was an accelerating increase in depressive symptom scores with age, but this did not appreciably affect genetic and environmental variances. Overlap in genetic influences between physical illness and depressive symptoms was greater in men than in women. Additionally, in men extent of overlap was greater with worse physical illness (the genetic correlation ranged from near 0.00 for the least physical illness to nearly 0.60 with physical illness 2s.d.above the mean). For men and women, the same environmental factors that influenced depressive symptoms also influenced physical illness.ConclusionsFindings suggested that genetic factors play a larger part in the association between depressive symptoms and physical illness for men than for women. For both sexes, across all ages, physical illness may similarly trigger social and health limitations that contribute to depressive symptoms.</jats:sec

Association between Radiologists' Experience and Accuracy in Interpreting Screening Mammograms

<p>Abstract</p> <p>Background</p> <p>Radiologists have been observed to differ, sometimes substantially, both in their interpretations of mammograms and in their recommendations for follow-up. The aim of this study was to determine how factors related to radiologists' experience affect the accuracy of mammogram readings.</p> <p>Methods</p> <p>We selected a random sample of screening mammograms from a population-based breast cancer screening program. The sample was composed of 30 women with histopathologically-confirmed breast cancer and 170 women without breast cancer after a 2-year follow-up (the proportion of cancers was oversampled). These 200 mammograms were read by 21 radiologists routinely interpreting mammograms, with different amount of experience, and by seven readers who did not routinely interpret mammograms. All readers were blinded to the results of the screening. A positive assessment was considered when a BI-RADS III, 0, IV, V was reported (additional evaluation required). Diagnostic accuracy was calculated through sensitivity and specificity.</p> <p>Results</p> <p>Average specificity was higher in radiologists routinely interpreting mammograms with regard to radiologists who did not (66% vs 56%; p < .001). Multivariate analysis based on routine readers alone showed that specificity was higher among radiologists who followed-up cases for which they recommended further workup (feedback) (OR 1.37; 95% CI 1.03 to 1.85), those spending less than 25% of the working day on breast radiology (OR 1.49; 95% CI 1.18 to 1.89), and those aged more than 45 years old (OR 1.33; 95% CI 1.12 to 1.59); the variable of average annual volume of mammograms interpreted by radiologists, classified as more or less than 5,000 mammograms per year, was not statistically significant (OR 1.06; 95% CI 0.90 to 1.25).</p> <p>Conclusion</p> <p>Among radiologists who read routinely, volume is not associated with better performance when interpreting screening mammograms, although specificity decreased in radiologists not routinely reading mammograms. Follow-up of cases for which further workup is recommended might reduce variability in mammogram readings and improve the quality of breast cancer screening programs.</p

InGaAlAsPN: A Materials System for Silicon Based Optoelectronics and Heterostructure Device Technologies

A new material system is proposed for silicon based opto-electronic and heterostructure devices; the silicon lattice matched compositions of the (In,Ga,Al)-(As,P)N 3-5 compounds. In this nitride alloy material system, the bandgap is expected to be direct at the silicon lattice matched compositions with a bandgap range most likely to be in the infrared to visible. At lattice constants ranging between those of silicon carbide and silicon, a wider bandgap range is expected to be available and the high quality material obtained through lattice matching could enable applications such as monolithic color displays, high efficiency multi-junction solar cells, opto-electronic integrated circuits for fiber communications, and the transfer of existing 3-5 technology to silicon

Effect of Novel Dietary Supplement on Metabolism in \u3cem\u3evitro\u3c/em\u3e and \u3cem\u3ein vivo\u3c/em\u3e

Obesity is an increasingly prevalent and preventable morbidity with multiple behavioral, surgical and pharmacological interventions currently available. Commercial dietary supplements are often advertised to stimulate metabolism and cause rapid weight and/or fat loss, although few well-controlled studies have demonstrated such effects. We describe a commercially available dietary supplement (purportedly containing caffeine, catechins, and other metabolic stimulators) on resting metabolic rate in humans, and on metabolism, mitochondrial content, and related gene expression in vitro. Human males ingested either a placebo or commercially available supplement (RF) in a randomized double-blind placebo-controlled cross-over fashion. Metabolic rate, respiratory exchange ratio, and blood pressure were measured hourly for 3 h post-ingestion. To investigate molecular effects, human rhabdomyosarcoma cells (RD) and mouse myocytes (C2C12) were treated with various doses of RF for various durations. RF enhanced energy expenditure and systolic blood pressure in human males without altering substrate utilization. In myocytes, RF enhanced metabolism, metabolic gene expression, and mitochondrial content suggesting RF may target common energetic pathways which control mitochondrial biogenesis. RF appears to increase metabolism immediately following ingestion, although it is unclear if RF provides benefits beyond those provided by caffeine alone. Additional research is needed to examine safety and efficacy for human weight loss

Sex differences in mate preferences across 45 countries: A large-scale replication

Considerable research has examined human mate preferences across cultures, finding universal sex differences in preferences for attractiveness and resources as well as sources of systematic cultural variation. Two competing perspectives-an evolutionary psychological perspective and a biosocial role perspective-offer alternative explanations for these findings. However, the original data on which each perspective relies are decades old, and the literature is fraught with conflicting methods, analyses, results, and conclusions. Using a new 45-country sample (N = 14,399), we attempted to replicate classic studies and test both the evolutionary and biosocial role perspectives. Support for universal sex differences in preferences remains robust: Men, more than women, prefer attractive, young mates, and women, more than men, prefer older mates with financial prospects. Cross-culturally, both sexes have mates closer to their own ages as gender equality increases. Beyond age of partner, neither pathogen prevalence nor gender equality robustly predicted sex differences or preferences across countries.info:eu-repo/semantics/acceptedVersio

Dispersive flies optimisation and medical imaging

One of the main sources of inspiration for techniques applicable to complex search space and optimisation problems is nature. This paper introduces a new metaheuristic—Dispersive Flies Optimisation (DFO)—whose inspiration is beckoned from the swarming behaviour of flies over food sources in nature. The simplicity of the algorithm facilitates the analysis of its behaviour. A series of experimental trials confirms the promising performance of the optimiser over a set of benchmarks, as well as its competitiveness when compared against three other well-known population based algorithms. The convergence-independent diversity of DFO algorithm makes it a potentially suitable candidate for dynamically changing environment. In addition to diversity, the performance of the newly introduced algorithm is investigated using the three performance measures of accuracy, efficiency and reliability and its outperformance is demonstrated in the paper. Then the proposed swarm intelligence algorithm is used as a tool to identify microcalcifications on the mammographs. This algorithm is adapted for this particular purpose and its performance is investigated by running the agents of the swarm intelligence algorithm on sample mammographs whose status have been determined by the experts. Two modes of the algorithms are introduced in the paper, each providing the clinicians with a different set of outputs, highlighting the areas of interest where more attention should be given by those in charge of the care of the patients