Screening for health risks: A social science perspective

Health screening promises to reduce risks to individuals via probabilistic sifting of populations for medical conditions. The categorisation and selection of 'conditions' such as cardiovascular events, dementia and depression for screening itself requires prior interpretive labour which usually remains unexamined. Screening systems can take diverse organisational forms and varying relationships to health status, as when purported disease precursors, for example 'pre-cancerous' polyps, or supposed risk factors, such as high cholesterol themselves, become targets for screening. Screening at best yields small, although not necessarily unworthwhile, net population health gains. It also creates new risks, leaving some individuals worse-off than if they had been left alone. The difficulties associated with attempting to measure small net gains through randomised controlled trials are sometimes underestimated. Despite endemic doubts about its clinical utility, bibliometric analysis of published papers shows that responses to health risks are coming to be increasingly thought about in terms of screening. This shift is superimposed on a strengthening tendency to view health through the lens of risk. It merits further scrutiny as a societal phenomenon

Strong Optomechanical Squeezing of Light

We create squeezed light by exploiting the quantum nature of the mechanical interaction between laser light and a membrane mechanical resonator embedded in an optical cavity. The radiation pressure shot noise (fluctuating optical force from quantum laser amplitude noise) induces resonator motion well above that of thermally driven motion. This motion imprints a phase shift on the laser light, hence correlating the amplitude and phase noise, a consequence of which is optical squeezing. We experimentally demonstrate strong and continuous optomechanical squeezing of 1.7 +/- 0.2 dB below the shot noise level. The peak level of squeezing measured near the mechanical resonance is well described by a model whose parameters are independently calibrated and that includes thermal motion of the membrane with no other classical noise sources.Comment: 12 pages, 8 figure

Aerodynamic design of the contoured wind-tunnel liner for the NASA supercritical, laminar-flow-control, swept-wing experiment

An overview is presented of the entire procedure developed for the aerodynamic design of the contoured wind tunnel liner for the NASA supercritical, laminar flow control (LFC), swept wing experiment. This numerical design procedure is based upon the simple idea of streamlining and incorporates several transonic and boundary layer analysis codes. The liner, presently installed in the Langley 8 Foot Transonic Pressure Tunnel, is about 54 ft long and extends from within the existing contraction cone, through the test section, and into the diffuser. LFC model testing has begun and preliminary results indicate that the liner is performing as intended. The liner design results presented in this paper, however, are examples of the calculated requirements and the hardware implementation of them

On the soft X-ray spectrum of cooling flows

Strong evidence for cooling flows has been found in low resolution X-ray imaging and spectra of many clusters of galaxies. However high resolution X-ray spectra of several clusters from the Reflection Grating Spectrometer (RGS) on XMM-Newton now show a soft X-ray spectrum inconsistent with a simple cooling flow. The main problem is a lack of the emission lines expected from gas cooling below 1--2 keV. Lines from gas at about 2--3 keV are observed, even in a high temperature cluster such as A 1835, indicating that gas is cooling down to about 2--3 keV, but is not found at lower temperatures. Here we discuss several solutions to the problem; heating, mixing, differential absorption and inhomogeneous metallicity. Continuous or sporadic heating creates further problems, including the targetting of the heat at the cooler gas and also the high total energy required. So far there is no clear observational evidence for widespread heating, or shocks, in cluster cores, except in radio lobes which occupy only part of the volume. The implied ages of cooling flows are short, at about 1 Gyr. Mixing. or absorption, of the cooling gas are other possibilities. Alternatively, if the metals in the intracluster medium are not uniformly spread but are clumped, then little line emission is expected from the gas cooling below 1 keV. The low metallicity part cools without line emission whereas the strengths of the soft X-ray lines from the metal-rich gas depend on the mass fraction of that gas and not on the abundance, since soft X-ray line emission dominates the cooling function below 2 keV.Comment: 5 pages, with 2 figures, submitted to MNRA

Analytical review of passive mass transfer of water vapor in a space suit

Engineering study and analysis of water vapor mass transfer in space sui

DISTRIBUTION, DIET, AND PREVALENCE OF AMPHIBIAN CHYTRID FUNGUS IN NON-NATIVE AMERICAN BULLFROGS (LITHOBATES CATESBEIANUS) AT THE VALENTINE NATIONAL WILDLIFE REFUGE, NEBRASKA, USA

American Bullfrogs (Lithobates catesbeianus) have been widely introduced beyond their native range in North America and can negatively affect organisms in wetland environments via a suite of mechanisms including interspecific interactions and disease transmission. Bullfrogs were introduced to the Valentine National Wildlife Refuge in the Sandhill Region of Nebraska, USA, yet little is known regarding their distribution, abundance, and potential effects on other vertebrates in the Refuge. Surveys in 1991-1992 documented bullfrogs in only one lake by the Refuge headquarters, and anecdotal historical observations indicated that bullfrogs were present primarily in lakes open to public fishing. In 2012, we determined the distribution of bullfrogs across the Refuge, examined their diets, and sampled them for the occurrence of the pathogenic fungus, Batrachochytrium dendrobatidis. We documented that bullfrogs were almost ubiquitous across the Refuge lakes and wetlands. From diet analyses, we observed that adult bullfrogs consumed several vertebrate species on the Refuge including: a Blanding’s Turtle (Emydoidea blandingii), small bullfrogs, an unidentifiable frog species, and numerous invertebrates, including crayfish. The amphibian chytrid fungus was prevalent on the refuge with 73.7% of bullfrogs testing positive for the fungus in early June and 6.3% in late June-July. Preliminary data indicate that bullfrogs likely have already affected interspecific interactions with native amphibians via predation, competition, and/or disease transmission. Bullfrogs likely cannot be eradicated from the Refuge, but expanding the season of harvest of bullfrogs might reduce their abundance, which may benefit native amphibians and reptiles

Diagnostics of the structure of AGN's broad line regions with reverberation mapping data: confirmation of the two-component broad line region model

We re-examine the ten Reverberation Mapping (RM) sources with public data based on the two-component model of the Broad Line Region (BLR). In fitting their broad H-beta lines, six of them only need one Gaussian component, one of them has a double-peak profile, one has an irregular profile, and only two of them need two components, i.e., a Very Broad Gaussian Component (VBGC) and an Inter-Mediate Gaussian Component (IMGC). The Gaussian components are assumed to come from two distinct regions in the two-component model; they are Very Broad Line Region (VBLR) and Inter-Mediate Line region (IMLR). The two sources with a two-component profile are Mrk 509 and NGC 4051. The time lags of the two components of both sources satisfy $t_{IMLR}/t_{VBLR}=V^2_{VBLR}/V^2_{IMLR}$, where $t_{IMLR}$ and $t_{VBLR}$ are the lags of the two components while $V_{IMLR}$ and $V_{VBLR}$ represent the mean gas velocities of the two regions, supporting the two-component model of the BLR of Active Galactic Nuclei (AGN). The fact that most of these ten sources only have the VBGC confirms the assumption that RM mainly measures the radius of the VBLR; consequently, the radius obtained from the R-L relationship mainly represent the radius of VBLR. Moreover, NGC 4051, with a lag of about 5 days in the one component model, is an outlier on the R-L relationship as shown in Kaspi et al. (2005); however this problem disappears in our two-component model with lags of about 2 and 6 days for the VBGC and IMGC, respectively.Comment: 7 pages, 5 figures. Accepted for publication in the Special Issue of Science in China (G) "Astrophysics of Black holes and Related Compact Objects