Rapid and robust spin state amplification

Electron and nuclear spins have been employed in many of the early demonstrations of quantum technology (QT). However applications in real world QT are limited by the difficulty of measuring single spins. Here we show that it is possible to rapidly and robustly amplify a spin state using a lattice of ancillary spins. The model we employ corresponds to an extremely simple experimental system: a homogenous Ising-coupled spin lattice in one, two or three dimensions, driven by a continuous microwave field. We establish that the process can operate at finite temperature (imperfect initial polarisation) and under the effects of various forms of decoherence.Comment: 5 pages, 2 figure

miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy

Hippocampal neural stem/progenitor cells (NSPCs) proliferate and differentiate to generate new neurons across the life span of most mammals, including humans. This process takes place within a characteristic local microenvironment where NSPCs interact with a variety of other cell types and encounter systemic regulatory factors. Within this microenvironment, cell intrinsic gene expression programs are modulated by cell extrinsic signals through complex interactions, in many cases involving short non-coding RNA molecules, such as miRNAs. Here we review the regulation of gene expression in NSPCs by miRNAs and its possible implications for epilepsy, which has been linked to alterations in adult hippocampal neurogenesis

Piloting and producing a map of Millennium Cohort Study Data usage: Where are data underutilised and where is granularity lost?

The UK Millennium Cohort Study (MCS) is a longitudinal interdisciplinary study following the lives of 19,000 children born in the UK in 2000/1. Information has been collected at 9 months, 3, 5, 7 and 11 years, with the next sweep of data collection underway among study members who are aged 14 years. A wide range of data have been collected from children, parents and guardians, the partners of parents/guardians, older siblings and teachers, as well as sub-studies that collected data from health visitors; these include self-reported and objectively measured/verified data. This study sets out to examine how MCS data are utilised. To fit within the remit of the study, we hone in on ten priority question areas (Strengths and Difficulties Questionnaire, Child Social Behaviour Questionnaire, Diet, BMI, Immunisations, School Dis/like, Self-reported Friendships, Self-reported feelings, Screen Time, Hobbies). In total we found 481 unique studies that were using MCS data and undertaking primary analysis up to July 2015. Data that are collected through a recognised scale with defined thresholds or cut-off points for identifying constructs of interest and/or data that can provide a unique insight into a policy-relevant issue, are those most widely used in the MCS data. Measures that have been collected across sweeps – diet, BMI, SDQ and screen time - are all comparatively well used. Those measures that have started to be collected at age 7 (and first made available in 2010) have had lower usage. Data that were collected from the child’s own reports (e.g. friendships and feelings) have seldom been utilised in comparison to data collected through parental reports (e.g. SDQ). Collection of data from multiple informants did not always correlate with higher levels of usage. Imposing thresholds on data was found to be problematic in some cases, for example for BMI, where a number of different thresholds for overweight and obesity were in use. The use of different thresholds can lead to substantial differences in the results obtained. This is the first review using systematic methods that has explored MCS data use. We set out a number of ideas for good practice around the use of and reporting of MCS data

Cross-verification of independent quantum devices

Quantum computers are on the brink of surpassing the capabilities of even the most powerful classical computers. This naturally raises the question of how one can trust the results of a quantum computer when they cannot be compared to classical simulation. Here we present a verification technique that exploits the principles of measurement-based quantum computation to link quantum circuits of different input size, depth, and structure. Our approach enables consistency checks of quantum computations within a device, as well as between independent devices. We showcase our protocol by applying it to five state-of-the-art quantum processors, based on four distinct physical architectures: nuclear magnetic resonance, superconducting circuits, trapped ions, and photonics, with up to 6 qubits and 200 distinct circuits

'Pedometers cost buttons': the feasibility of implementing a pedometer based walking programme within the community

Background: Recent studies have suggested that walking interventions may be effective (at least in the short term) at increasing physical activity amongst those people who are the most inactive. This is a leading objective of contemporary public health policy in the UK and worldwide. However, before committing money from limited budgets to implement walking interventions more widely in the community, policymakers will want to know whether similar impacts can be expected and whether any changes will be required to the process to ensure uptake and success. This paper utilises the findings from a recent community-based pedometer study (Walking for Wellbeing in the West - WWW) undertaken in Glasgow, Scotland to address issues of feasibility. Methods: An economic analysis of the WWW study assessed the costs of the interventions (minimal and maximal) and combined these with the effects to present incremental cost-effectiveness ratios (cost/person achieving the target of an additional 15,000 steps/week). A qualitative evaluation, involving focus group discussions with WWW participants and short interviews with members of the WWW research team, explored perceived benefits and barriers associated with walking, as well as the successful aspects and challenges associated with the interventions. Results: The incremental cost effectiveness associated with the interventions was estimated as (sic)92 and (sic)591 per person achieving the target for the minimal and maximal interventions respectively. The qualitative evaluation gave insight into the process by which the results were achieved, and identified several barriers and facilitators that would need to be addressed before implementing the interventions in the wider community, in order to ensure their effective transfer. These included assessing the impact of the relationship between researchers and participants on the results, and the motivational importance of monitoring and assessing performance. Conclusions: The results suggest that pedometer based walking interventions may be considered cost-effective and suitable for implementation within the wider community. However, several research gaps remain, including the importance and impact of the researcher/participant relationship, the impact of assessment on motivation and effectiveness, and the longer term impact on physical and mental health, resource utilisation and quality of life

Adult Neural Stem Cell Regulation by Small Non-coding RNAs: Physiological Significance and Pathological Implications

The adult neurogenic niches are complex multicellular systems, receiving regulatory input from a multitude of intracellular, juxtacrine, and paracrine signals and biological pathways. Within the niches, adult neural stem cells (aNSCs) generate astrocytic and neuronal progeny, with the latter predominating in physiological conditions. The new neurons generated from this neurogenic process are functionally linked to memory, cognition, and mood regulation, while much less is known about the functional contribution of aNSC-derived newborn astrocytes and adult-born oligodendrocytes. Accumulating evidence suggests that the deregulation of aNSCs and their progeny can impact, or can be impacted by, aging and several brain pathologies, including neurodevelopmental and mood disorders, neurodegenerative diseases, and also by insults, such as epileptic seizures, stroke, or traumatic brain injury. Hence, understanding the regulatory underpinnings of aNSC activation, differentiation, and fate commitment could help identify novel therapeutic avenues for a series of pathological conditions. Over the last two decades, small non-coding RNAs (sncRNAs) have emerged as key regulators of NSC fate determination in the adult neurogenic niches. In this review, we synthesize prior knowledge on how sncRNAs, such as microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs), may impact NSC fate determination in the adult brain and we critically assess the functional significance of these events. We discuss the concepts that emerge from these examples and how they could be used to provide a framework for considering aNSC (de)regulation in the pathogenesis and treatment of neurological diseases

Does physical activity counselling enhance the effects of a pedometer-based intervention over the long-term : 12-month findings from the Walking for Wellbeing in the West study

Peer reviewedPublisher PD

Identification and analysis of low-molecular-weight dissolved organic carbon in subglacial basal ice ecosystems by ion chromatography

Determining the concentration and composition of dissolved organic carbon (DOC) in glacial ecosystems is important for assessments of in situ microbial activity and contributions to wider biogeochemical cycles. Nonetheless, there is limited knowledge of the abundance and character of DOC in basal ice and the subglacial environment and a lack of quantitative data on low-molecular-weight (LMW) DOC components, which are believed to be highly bioavailable to microorganisms. We investigated the abundance and composition of DOC in basal ice via a molecular-level DOC analysis. Spectrofluorometry and a novel ion chromatographic method, which has been little utilized in glacial science for LMW-DOC determinations, were employed to identify and quantify the major LMW fractions (free amino acids, carbohydrates, and carboxylic acids) in basal ice from four glaciers, each with a different type of overridden material (i.e. the pre-entrainment sedimentary type such as lacustrine material or palaeosols). Basal ice from Joyce Glacier (Antarctica) was unique in that 98% of the LMW-DOC was derived from the extremely diverse free amino acid (FAA) pool, comprising 14 FAAs. LMW-DOC concentrations in basal ice were dependent on the bioavailability of the overridden organic carbon (OC), which in turn was influenced by the type of overridden material. Mean LMW-DOC concentrations in basal ice from Russell Glacier (Greenland), Finsterwalderbreen (Svalbard), and Engabreen (Norway) were low (0–417nMC), attributed to the relatively refractory nature of the OC in the overridden palaeosols and bedrock. In contrast, mean LMW-DOC concentrations were an order of magnitude higher (4430nMC) in basal ice from Joyce Glacier, a reflection of the high bioavailability of the overridden lacustrine material (> 17% of the sediment OC comprised extractable carbohydrates, a proxy for bioavailable OC). We find that the overridden material may act as a direct (via abiotic leaching) and indirect (via microbial cycling) source of DOC to the subglacial environment and provides a range of LMW-DOC compounds that may stimulate microbial activity in wet subglacial sediments

Compressional and extensional tectonics in low-medium pressure granulites from the Larsemann Hills, east Antarctica

AbstractMeta-sediments in the Larsemann Hills that preserve a coherent stratigraphy, form a cover sequence deposited upon basement of mafic–felsic granulite. Their outcrop pattern defines a 10 kilometre wide east–west trending synclinal trough structure in which basement–cover contacts differ in the north and the south, suggesting tectonic interleaving during a prograde, D1 thickening event. Subsequent conditions reached low-medium pressure granulite grade, and structures can be divided into two groups, D2 and D3, each defined by a unique lineation direction and shear sense. D2 structures which are associated with the dominant gneissic foliation in much of the Larsemann Hills, contain a moderately east-plunging lineation indicative of west-directed thrusting. D2 comprises a colinear fold sequence that evolved from early intrafolial folds to late upright folds. D3 structures are associated with a high-strain zone, to the south of the Larsemann Hills, where S3 is the dominant gneissic layering and folds sequences resemble D2 folding. Outside the D3 high-strain zone occurs a low-strain D3 window, preserving low-strain D3 structures (minor shear bands and upright folds) that partly re-orient D2 structures. All structures are truncated by a series of planar pegmatites and parallel D4 mylonite zones, recording extensional dextral displacements.D2 assemblages include coexisting garnet–orthopyroxene pairs recording peak conditions of ∼ 7 kbar and ∼ 780°C. Subsequent retrograde decompression textures partly evolved during both D2 and D3 when conditions of ∼ 4–5 kbar and ∼ 750°C were attained. This is followed by D4 shear zones which formed around 3 kbar and ∼ 550°C.It is tempting to combine D2–4 structures in one tectonic cycle involving prograde thrusting and thickening followed by retrograde extension and uplift. The available geochronological data, however, present a number of interpretations. For example, D2 was possibly associated with a clockwise P–T path at medium pressures around ∼ 1000 Ma, by correlation with similar structures developed in the Rauer Group, whilst D3 and D4 events occurred in response to extension and heating at low pressures at ∼ 550 Ma, associated with the emplacement of numerous granitoid bodies. Thus, decompression textures typical for the Larsemann Hills granulites maybe the combined effect of two separate events.C. J. Carson, P. G. H. M. Dirks, M. Hand, J. P. Sims & C. J. L. Wilso