1,453 research outputs found
ASSESSMENT OF PUBLIC KNOWLEDGE AND ATTITUDE REGARDING ANTIBIOTIC USE IN A TERTIARY CARE HOSPITAL
Objective: The present study was designed to investigate the public knowledge and attitude toward antibiotic use in a general population visiting thetertiary care hospital.Methods: A prospective cross-sectional survey conducted for a period of 6-month December-2013 to May-2014. Knowledge scoring was given basedon the percentage of correct responses. Data were collected using a self-prepared questionnaire and analyzed using descriptive statistics. Associationof respondent's knowledge score with sex, age group, educational level, and income was analyzed by Chi-square test.Results: The results of our study showed that the level of knowledge on antibiotics use was poor in 117 (65%) of the study population who had given<50% correct response. The current study showed that there was a significant difference in knowledge between education level groups (p≤0.0001).The other responses regarding knowledge are 27.2% accepted that antibiotics are indicated for relieving pain and inflammation, 45% of participantsthought that antibiotics are the drugs indicated to reduce fever. About 76.6% of respondents had administered antibiotics without a doctor'sprescription, 44% of respondents used antibiotics with their friends and family member's suggestions. 48% of respondents keep antibiotics stockat home for future use and 79.4% of respondents keep leftover antibiotics for personal future use, 31% share their antibiotics with family memberswhen they are sick and 34% of respondents use leftover antibiotics for a respiratory illness.Conclusion: Patients, as well as healthcare professionals, have a major role to play in attaining rational antibiotic use. Antibiotic awareness campaignsand patient counseling should promote specific messages to public members from the high risk†groups, to fill up the knowledge and attitude gaps.Keywords: Antibiotic use, Self-medication, Attitude, Miss-use, Awareness, Microbial resistance
Predicting and Recovering Link Failure Localization Using Competitive Swarm Optimization for DSR Protocol in MANET
Portable impromptu organization is a self-putting together, major construction-less, independent remote versatile hub that exists without even a trace of a determined base station or government association. MANET requires no extraordinary foundation as the organization is unique. Multicasting is an urgent issue in correspondence organizations. Multicast is one of the effective methods in MANET. In multicasting, information parcels from one hub are communicated to a bunch of recipient hubs all at once, at a similar time. In this research work, Failure Node Detection and Efficient Node Localization in a MANET situation are proposed. Localization in MANET is a main area that attracts significant research interest. Localization is a method to determine the nodes’ location in the communication network. A novel routing algorithm, which is used for Predicting and Recovering Link Failure Localization using a Genetic Algorithm with Competitive Swarm Optimization (PRLFL-GACSO) Algorithm is proposed in this study to calculate and recover link failure in MANET. The process of link failure detection is accomplished using mathematical modelling of the genetic algorithm and the routing is attained using the Competitive Swarm optimization technique. The result proposed MANET method makes use of the CSO algorithm, which facilitates a well-organized packet transfer from the source node to the destination node and enhances DSR routing performance. Based on node movement, link value, and endwise delay, the optimal route is found. The main benefit of the PRLFL-GACSO Algorithm is it achieves multiple optimal solutions over global information. Further, premature convergence is avoided using Competitive Swarm Optimization (CSO). The suggested work is measured based on the Ns simulator. The presentation metrix are PDR, endwise delay, power consumption, hit ratio, etc. The presentation of the proposed method is almost 4% and 5% greater than the present TEA-MDRP, RSTA-AOMDV, and RMQS-ua methods. After, the suggested method attains greater performance for detecting and recovering link failure. In future work, the hybrid multiway routing protocols are presented to provide link failure and route breakages and liability tolerance at the time of node failure, and it also increases the worth of service aspects, respectively
SCREENING OF DRUG RELATED PROBLEMS IN HIV PATIENTS RECEIVING ANTI RETROVIRAL THERAPY
Aim: The main aim of the study is prospective screening of drug related problems in ART receiving patients at RIMS Kadapa. Objectives: The key objectives of the study include To identify various drug related problems using various domains as per PCNE (Pharmaceutical care network Europe). To identify the most common ART regimen causing DRP. Methodology: A prospective observational study conducted for a period of six months november2015-april 2016. The data was collected by using Patient Data Collection Form, PCNE classification V5.01, Drug interaction form, ADR form. The collected data was analysed for age and gender distribution, distribution of patients based on co morbidities, patients with and without DRPs based on type of ART regimen used, distribution of problems, causes for different problems, interventions suggested for different problems then outcome of interventions were calculated. Results: A total of 125 patients 104 members experienced DRPs with ART regimens, which accounts 63(60.57%) males and 41(39.42%) females. Out of 104 patients 59 members experienced DRPs with ZLN regimen. In those patients the main DRPs were adverse drug reactions, drug use problems and drug interactions. The main causes for those problems were Pharmacokinetic problems incl. Ageing/ deterioration in organ function and interactions (C1.4), manifest side effect no other cause (C1.8) as per PCNE scheme V5.01. The various interventions suggested for those problems were Patient (medication) counselling (I2.1), Instructions for use changed to......(I3.4), new drug started(I3.6). the outcomes for suggested interventions were problems( Rashes, muscle pain, vomiting, nausea, headache, cough, abdominal pain.....etc.) totally solved(O1.0) and problems (Neutropenia, anaemia, hyper pigmentation of skin & nails, ear impairment, severe anaemia, finger paralysis, blurred vision.....etc.) were partially solved(O2.0). Conclusion: Our study concludes adverse drug reactions with ART are high in problems domain as per PCNE, which can be decreased by identifying DRPs in early stages of drug therapy, prescribing other drugs cautiously in HIV patients. Majority of DRPs can be decreased by improving patient-physician relationships and patient-pharmacist relationships. For better outcomes patient counselling can be considered as a better interventional tool which will improve adherence and decrease DRPs in HIV patients. Keywords: Pharmaceutical Care Network Europe, Drug related problems, Anti retro viral therapyÂ
Human protein reference database—2006 update
Human Protein Reference Database (HPRD) () was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data
Observation of Cabibbo-suppressed two-body hadronic decays and precision mass measurement of the baryon
The first observation of the singly Cabibbo-suppressed
and decays
is reported, using proton-proton collision data at a centre-of-mass energy of
, corresponding to an integrated luminosity of , collected with the LHCb detector between 2016 and 2018. The
branching fraction ratios are measured to be
,
. In addition, using the
decay channel, the baryon
mass is measured to be , improving the
precision of the previous world average by a factor of four.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-011.html (LHCb
public pages
Study of charmonium decays to in the channels
A study of the and decays
is performed using proton-proton collisions at center-of-mass energies of 7, 8
and 13 TeV at the LHCb experiment. The invariant mass spectra from
both decay modes reveal a rich content of charmonium resonances. New precise
measurements of the and resonance parameters are
performed and branching fraction measurements are obtained for decays to
, , and resonances. In particular, the
first observation and branching fraction measurement of is reported as well as first measurements of the
and branching fractions. Dalitz plot analyses of
and decays are performed. A
new measurement of the amplitude and phase of the -wave as functions
of the mass is performed, together with measurements of the
, and parameters. Finally, the branching
fractions of decays to resonances are also measured.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-051.html (LHCb
public pages
Measurement of boson production cross-section in collisions at TeV
The first measurement of the boson production cross-section at
centre-of-mass energy TeV in the forward region is reported,
using collision data collected by the LHCb experiment in year 2017,
corresponding to an integrated luminosity of . The
production cross-section is measured for final-state muons in the
pseudorapidity range . The integrated cross-section is determined to be for the di-muon invariant
mass in the range . This result and the
differential cross-section results are in good agreement with theoretical
predictions at next-to-next-to-leading order in the strong coupling.
Based on a previous LHCb measurement of the boson production
cross-section in Pb collisions at TeV, the nuclear
modification factor is measured for the first time at this
energy. The measured values are in the forward region () and
in the backward region
(), where represents the muon rapidity in
the centre-of-mass frame.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-010.html (LHCb
public pages
Studies of and production in and Pb collisions
The production of and mesons is studied in proton-proton and
proton-lead collisions collected with the LHCb detector. Proton-proton
collisions are studied at center-of-mass energies of and ,
and proton-lead collisions are studied at a center-of-mass energy per nucleon
of . The studies are performed in center-of-mass rapidity
regions (forward rapidity) and
(backward rapidity) defined relative to the proton beam direction. The
and production cross sections are measured differentially as a function
of transverse momentum for and , respectively. The differential cross sections are used to
calculate nuclear modification factors. The nuclear modification factors for
and mesons agree at both forward and backward rapidity, showing
no significant evidence of mass dependence. The differential cross sections of
mesons are also used to calculate cross section ratios,
which show evidence of a deviation from the world average. These studies offer
new constraints on mass-dependent nuclear effects in heavy-ion collisions, as
well as and meson fragmentation.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://lhcbproject.web.cern.ch/Publications/p/LHCb-PAPER-2023-030.html (LHCb
public pages
Amplitude analysis of the Λb0→pK−γ decay
The resonant structure of the radiative decay Λb0→pK−γ in the region of proton-kaon invariant-mass up to 2.5 GeV/c2 is studied using proton-proton collision data recorded at centre-of-mass energies of 7, 8, and 13 TeV collected with the LHCb detector, corresponding to a total integrated luminosity of 9 fb−1. Results are given in terms of fit and interference fractions between the different components contributing to this final state. Only Λ resonances decaying to pK− are found to be relevant, where the largest contributions stem from the Λ(1520), Λ(1600), Λ(1800), and Λ(1890) states
- …