1,453 research outputs found

    ASSESSMENT OF PUBLIC KNOWLEDGE AND ATTITUDE REGARDING ANTIBIOTIC USE IN A TERTIARY CARE HOSPITAL

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    Objective: The present study was designed to investigate the public knowledge and attitude toward antibiotic use in a general population visiting thetertiary care hospital.Methods: A prospective cross-sectional survey conducted for a period of 6-month December-2013 to May-2014. Knowledge scoring was given basedon the percentage of correct responses. Data were collected using a self-prepared questionnaire and analyzed using descriptive statistics. Associationof respondent's knowledge score with sex, age group, educational level, and income was analyzed by Chi-square test.Results: The results of our study showed that the level of knowledge on antibiotics use was poor in 117 (65%) of the study population who had given<50% correct response. The current study showed that there was a significant difference in knowledge between education level groups (p≤0.0001).The other responses regarding knowledge are 27.2% accepted that antibiotics are indicated for relieving pain and inflammation, 45% of participantsthought that antibiotics are the drugs indicated to reduce fever. About 76.6% of respondents had administered antibiotics without a doctor'sprescription, 44% of respondents used antibiotics with their friends and family member's suggestions. 48% of respondents keep antibiotics stockat home for future use and 79.4% of respondents keep leftover antibiotics for personal future use, 31% share their antibiotics with family memberswhen they are sick and 34% of respondents use leftover antibiotics for a respiratory illness.Conclusion: Patients, as well as healthcare professionals, have a major role to play in attaining rational antibiotic use. Antibiotic awareness campaignsand patient counseling should promote specific messages to public members from the high risk†groups, to fill up the knowledge and attitude gaps.Keywords: Antibiotic use, Self-medication, Attitude, Miss-use, Awareness, Microbial resistance

    Predicting and Recovering Link Failure Localization Using Competitive Swarm Optimization for DSR Protocol in MANET

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    Portable impromptu organization is a self-putting together, major construction-less, independent remote versatile hub that exists without even a trace of a determined base station or government association. MANET requires no extraordinary foundation as the organization is unique. Multicasting is an urgent issue in correspondence organizations. Multicast is one of the effective methods in MANET. In multicasting, information parcels from one hub are communicated to a bunch of recipient hubs all at once, at a similar time. In this research work, Failure Node Detection and Efficient Node Localization in a MANET situation are proposed. Localization in MANET is a main area that attracts significant research interest. Localization is a method to determine the nodes’ location in the communication network. A novel routing algorithm, which is used for Predicting and Recovering Link Failure Localization using a Genetic Algorithm with Competitive Swarm Optimization (PRLFL-GACSO) Algorithm is proposed in this study to calculate and recover link failure in MANET. The process of link failure detection is accomplished using mathematical modelling of the genetic algorithm and the routing is attained using the Competitive Swarm optimization technique. The result proposed MANET method makes use of the CSO algorithm, which facilitates a well-organized packet transfer from the source node to the destination node and enhances DSR routing performance. Based on node movement, link value, and endwise delay, the optimal route is found. The main benefit of the PRLFL-GACSO Algorithm is it achieves multiple optimal solutions over global information. Further, premature convergence is avoided using Competitive Swarm Optimization (CSO). The suggested work is measured based on the Ns simulator. The presentation metrix are PDR, endwise delay, power consumption, hit ratio, etc. The presentation of the proposed method is almost 4% and 5% greater than the present TEA-MDRP, RSTA-AOMDV, and RMQS-ua methods. After, the suggested method attains greater performance for detecting and recovering link failure. In future work, the hybrid multiway routing protocols are presented to provide link failure and route breakages and liability tolerance at the time of node failure, and it also increases the worth of service aspects, respectively

    SCREENING OF DRUG RELATED PROBLEMS IN HIV PATIENTS RECEIVING ANTI RETROVIRAL THERAPY

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    Aim: The main aim of the study is prospective screening of drug related problems in ART receiving patients at RIMS Kadapa. Objectives: The key objectives of the study include To identify various drug related problems using various domains as per PCNE (Pharmaceutical care network Europe). To identify the most common ART regimen causing DRP. Methodology: A prospective observational study conducted for a period of six months november2015-april 2016. The data was collected by using Patient Data Collection Form, PCNE classification V5.01, Drug interaction form, ADR form. The collected data was analysed for age and gender distribution, distribution of patients based on co morbidities, patients with and without DRPs based on type of ART regimen used, distribution of problems, causes for different problems, interventions suggested for different problems then outcome of interventions were calculated. Results: A total of 125 patients 104 members experienced DRPs with ART regimens, which accounts 63(60.57%) males and 41(39.42%) females. Out of 104 patients 59 members experienced DRPs with ZLN regimen. In those patients the main DRPs were adverse drug reactions, drug use problems and drug interactions. The main causes for those problems were Pharmacokinetic problems incl. Ageing/ deterioration in organ function and interactions (C1.4), manifest side effect no other cause (C1.8) as per PCNE scheme V5.01. The various interventions suggested for those problems were Patient (medication) counselling (I2.1), Instructions for use changed to......(I3.4), new drug started(I3.6). the outcomes for suggested interventions were problems( Rashes, muscle pain, vomiting, nausea, headache, cough, abdominal pain.....etc.) totally solved(O1.0) and problems (Neutropenia, anaemia, hyper pigmentation of skin & nails, ear impairment, severe anaemia, finger paralysis, blurred vision.....etc.) were partially solved(O2.0). Conclusion: Our study concludes adverse drug reactions with ART are high in problems domain as per PCNE, which can be decreased by identifying DRPs in early stages of drug therapy, prescribing other drugs cautiously in HIV patients. Majority of DRPs can be decreased by improving patient-physician relationships and patient-pharmacist relationships. For better outcomes patient counselling can be considered as a better interventional tool which will improve adherence and decrease DRPs in HIV patients. Keywords: Pharmaceutical Care Network Europe, Drug related problems, Anti retro viral therapyÂ

    Human protein reference database—2006 update

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    Human Protein Reference Database (HPRD) () was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data

    Observation of Cabibbo-suppressed two-body hadronic decays and precision mass measurement of the Ωc0\Omega_{c}^{0} baryon

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    The first observation of the singly Cabibbo-suppressed Ωc0ΩK+\Omega_{c}^{0}\to\Omega^{-}K^{+} and Ωc0Ξπ+\Omega_{c}^{0}\to\Xi^{-}\pi^{+} decays is reported, using proton-proton collision data at a centre-of-mass energy of 13TeV13\,{\rm TeV}, corresponding to an integrated luminosity of 5.4fb15.4\,{\rm fb}^{-1}, collected with the LHCb detector between 2016 and 2018. The branching fraction ratios are measured to be B(Ωc0ΩK+)B(Ωc0Ωπ+)=0.0608±0.0051(stat)±0.0040(syst)\frac{\mathcal{B}(\Omega_{c}^{0}\to\Omega^{-}K^{+})}{\mathcal{B}(\Omega_{c}^{0}\to\Omega^{-}\pi^{+})}=0.0608\pm0.0051({\rm stat})\pm 0.0040({\rm syst}), B(Ωc0Ξπ+)B(Ωc0Ωπ+)=0.1581±0.0087(stat)±0.0043(syst)±0.0016(ext)\frac{\mathcal{B}(\Omega_{c}^{0}\to\Xi^{-}\pi^{+})}{\mathcal{B}(\Omega_{c}^{0}\to\Omega^{-}\pi^{+})}=0.1581\pm0.0087({\rm stat})\pm0.0043({\rm syst})\pm0.0016({\rm ext}). In addition, using the Ωc0Ωπ+\Omega_{c}^{0}\to\Omega^{-}\pi^{+} decay channel, the Ωc0\Omega_{c}^{0} baryon mass is measured to be M(Ωc0)=2695.28±0.07(stat)±0.27(syst)±0.30(ext)MeV/c2M(\Omega_{c}^{0})=2695.28\pm0.07({\rm stat})\pm0.27({\rm syst})\pm0.30({\rm ext})\,{\rm MeV}/c^{2}, improving the precision of the previous world average by a factor of four.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-011.html (LHCb public pages

    Study of charmonium decays to KS0KπK^0_S K \pi in the B(KS0Kπ)KB \to (K^0_S K \pi) K channels

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    A study of the B+KS0K+Kπ+B^+\to K^0_SK^+K^-\pi^+ and B+KS0K+K+πB^+\to K^0_SK^+K^+\pi^- decays is performed using proton-proton collisions at center-of-mass energies of 7, 8 and 13 TeV at the LHCb experiment. The KS0KπK^0_SK \pi invariant mass spectra from both decay modes reveal a rich content of charmonium resonances. New precise measurements of the ηc\eta_c and ηc(2S)\eta_c(2S) resonance parameters are performed and branching fraction measurements are obtained for B+B^+ decays to ηc\eta_c, J/ψJ/\psi, ηc(2S)\eta_c(2S) and χc1\chi_{c1} resonances. In particular, the first observation and branching fraction measurement of B+χc0K0π+B^+ \to \chi_{c0} K^0 \pi^+ is reported as well as first measurements of the B+K0K+Kπ+B^+\to K^0K^+K^-\pi^+ and B+K0K+K+πB^+\to K^0K^+K^+\pi^- branching fractions. Dalitz plot analyses of ηcKS0Kπ\eta_c \to K^0_SK\pi and ηc(2S)KS0Kπ\eta_c(2S) \to K^0_SK\pi decays are performed. A new measurement of the amplitude and phase of the KπK \pi SS-wave as functions of the KπK \pi mass is performed, together with measurements of the K0(1430)K^*_0(1430), K0(1950)K^*_0(1950) and a0(1700)a_0(1700) parameters. Finally, the branching fractions of χc1\chi_{c1} decays to KK^* resonances are also measured.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-051.html (LHCb public pages

    Measurement of ZZ boson production cross-section in pppp collisions at s=5.02\sqrt{s} = 5.02 TeV

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    The first measurement of the ZZ boson production cross-section at centre-of-mass energy s=5.02\sqrt{s} = 5.02\,TeV in the forward region is reported, using pppp collision data collected by the LHCb experiment in year 2017, corresponding to an integrated luminosity of 100±2pb1100 \pm 2\,\rm{pb^{-1}}. The production cross-section is measured for final-state muons in the pseudorapidity range 2.020GeV/c2.0 20\,\rm{GeV/}\it{c}. The integrated cross-section is determined to be σZμ+μ=39.6±0.7(stat)±0.6(syst)±0.8(lumi) pb \sigma_{Z \rightarrow \mu^{+}\mu^{-}} = 39.6 \pm 0.7\,(\rm{stat}) \pm 0.6\,(\rm{syst}) \pm 0.8\,(\rm{lumi}) \ \rm{pb} for the di-muon invariant mass in the range 60<Mμμ<120GeV/c260<M_{\mu\mu}<120\,\rm{GeV/}\it{c^{2}}. This result and the differential cross-section results are in good agreement with theoretical predictions at next-to-next-to-leading order in the strong coupling. Based on a previous LHCb measurement of the ZZ boson production cross-section in ppPb collisions at sNN=5.02\sqrt{s_{NN}}=5.02 TeV, the nuclear modification factor RpPbR_{p\rm{Pb}} is measured for the first time at this energy. The measured values are 1.20.3+0.5(stat)±0.1(syst)1.2^{+0.5}_{-0.3}\,(\rm{stat}) \pm 0.1\,(\rm{syst}) in the forward region (1.53<yμ<4.031.53<y^*_{\mu}<4.03) and 3.60.9+1.6(stat)±0.2(syst)3.6^{+1.6}_{-0.9}\,(\rm{stat}) \pm 0.2\,(\rm{syst}) in the backward region (4.97<yμ<2.47-4.97<y^*_{\mu}<-2.47), where yμy^*_{\mu} represents the muon rapidity in the centre-of-mass frame.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-010.html (LHCb public pages

    Studies of η\eta and η\eta' production in pppp and ppPb collisions

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    The production of η\eta and η\eta' mesons is studied in proton-proton and proton-lead collisions collected with the LHCb detector. Proton-proton collisions are studied at center-of-mass energies of 5.025.02 and 13 TeV13~{\rm TeV}, and proton-lead collisions are studied at a center-of-mass energy per nucleon of 8.16 TeV8.16~{\rm TeV}. The studies are performed in center-of-mass rapidity regions 2.5<yc.m.<3.52.5<y_{\rm c.m.}<3.5 (forward rapidity) and 4.0<yc.m.<3.0-4.0<y_{\rm c.m.}<-3.0 (backward rapidity) defined relative to the proton beam direction. The η\eta and η\eta' production cross sections are measured differentially as a function of transverse momentum for 1.5<pT<10 GeV1.5<p_{\rm T}<10~{\rm GeV} and 3<pT<10 GeV3<p_{\rm T}<10~{\rm GeV}, respectively. The differential cross sections are used to calculate nuclear modification factors. The nuclear modification factors for η\eta and η\eta' mesons agree at both forward and backward rapidity, showing no significant evidence of mass dependence. The differential cross sections of η\eta mesons are also used to calculate η/π0\eta/\pi^0 cross section ratios, which show evidence of a deviation from the world average. These studies offer new constraints on mass-dependent nuclear effects in heavy-ion collisions, as well as η\eta and η\eta' meson fragmentation.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/Publications/p/LHCb-PAPER-2023-030.html (LHCb public pages

    Amplitude analysis of the Λb0→pK−γ decay

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    The resonant structure of the radiative decay Λb0→pK−γ in the region of proton-kaon invariant-mass up to 2.5 GeV/c2 is studied using proton-proton collision data recorded at centre-of-mass energies of 7, 8, and 13 TeV collected with the LHCb detector, corresponding to a total integrated luminosity of 9 fb−1. Results are given in terms of fit and interference fractions between the different components contributing to this final state. Only Λ resonances decaying to pK− are found to be relevant, where the largest contributions stem from the Λ(1520), Λ(1600), Λ(1800), and Λ(1890) states
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