New Constraints on the Timing and Pattern of Deglaciation in the Húnaflói Bay Region of Northwest Iceland Using Cosmogenic 36CA Dating and Geomorphic Mapping

Understanding the evolution and timing of changes in ice sheet geometry and extent in Iceland during the Last Glacial Maximum (LGM) and subsequent deglaciation continues to stimulate much active research. Though many previous studies have advanced our knowledge of Icelandic ice sheet history preserved in marine and terrestrial settings (e.g., Andrews et al., 2000; Norðdahl et al., 2008), the timing of ice margin retreat remains largely unknown in several key regions. Recently published 36Cl surface exposure ages of bedrock surfaces and moraines in the West Fjords (Brynjólfsson et al., 2015) contribute important progress in establishing more precise age control of ice recession in northwest Iceland. In another recent study, the spatial pattern and style of deglaciation in northern Iceland have been revealed through geomorphic mapping and GIS analyses of glacial landforms (Principato et al., 2016). Additional insight comes from updated numerical modeling reconstructions, which now provide a series of glaciologically plausible Icelandic ice sheet configurations from the LGM through the last deglaciation (Patton et al., 2017). However, the optimization of ice sheet model simulations relies on critical comparisons with the available empirical record of glacial-geologic evidence and chronological control, which remains relatively limited and sparsely distributed throughout Iceland. Our investigation is motivated by the need for more accurate constraints on the deglacial history in northern Iceland, where dated terrestrial records of ice margin retreat are particularly scarce. (excerpt

Las representaciones pictóricas como recursos semióticos. Caso equilibrio químico

De acuerdo con Orlandi (1996) tres variables intervienen en el proceso de producción de sentidos: la intencionalidad del autor, la materialidad del texto y las posibilidades de resignificación del lector. Las dos primeras no pueden ser modificadas por el lector. Las posibilidades del lector para atribuir significados pueden ser modificadas conociendo los diferentes tipos de Representaciones Externas Pictóricas (REP) y los recursos semióticos que se utilizan en su construcción. Se diseña una intervención dirigida a dar a conocer este contenido para dos tipos REP y así facilitar operar con éstas. Los resultados indican que las REP ejercen una doble influencia: a) cuando la tarea se realiza a partir de una REP o b) cuando la tarea es construir la REP. En ambos casos se encuentra que cada tipo de representación permite la recuperación de una información específica y diferente

Epigenome targeting by probiotic metabolites

BACKGROUND: The intestinal microbiota plays an important role in immune development and homeostasis. A disturbed microbiota during early infancy is associated with an increased risk of developing inflammatory and allergic diseases later in life. The mechanisms underlying these effects are poorly understood but are likely to involve alterations in microbial production of fermentation-derived metabolites, which have potent immune modulating properties and are required for maintenance of healthy mucosal immune responses. Probiotics are beneficial bacteria that have the capacity to alter the composition of bacterial species in the intestine that can in turn influence the production of fermentation-derived metabolites. Principal among these metabolites are the short-chain fatty acids butyrate and acetate that have potent anti-inflammatory activities important in regulating immune function at the intestinal mucosal surface. Therefore strategies aimed at restoring the microbiota profile may be effective in the prevention or treatment of allergic and inflammatory diseases. PRESENTATION OF THE HYPOTHESIS: Probiotic bacteria have diverse effects including altering microbiota composition, regulating epithelial cell barrier function and modulating of immune responses. The precise molecular mechanisms mediating these probiotic effects are not well understood. Short-chain fatty acids such as butyrate are a class of histone deacetylase inhibitors important in the epigenetic control of host cell responses. It is hypothesized that the biological function of probiotics may be a result of epigenetic modifications that may explain the wide range of effects observed. Studies delineating the effects of probiotics on short-chain fatty acid production and the epigenetic actions of short-chain fatty acids will assist in understanding the association between microbiota and allergic or autoimmune disorders. TESTING THE HYPOTHESIS: We propose that treatment with specific probiotic bacteria under in vivo conditions would offer the ideal conditions to examine the microbiological, immunological and epigenetic mechanisms of action. Advances in epigenetic technology now allow investigators to better understand the complex biological properties of probiotics and their metabolites. IMPLICATIONS OF THE HYPOTHESIS: Determining the precise mechanisms of probiotic action will lead to more specific and efficacious therapeutic strategies in the prevention or treatment of chronic inflammatory conditions

Characterization of 19A-like 19F pneumococcal isolates from Papua New Guinea and Fiji.

Molecular identification of Streptococcus pneumoniae serotype 19F is routinely performed by PCR targeting the wzy gene of the capsular biosynthetic locus. However, 19F isolates with genetic similarity to 19A have been reported in the United States and Brazil. We screened 78 pneumococcal carriage isolates and found six 19F wzy variants that originated from children in Papua New Guinea and Fiji. Isolates were characterized using multilocus sequence typing and opsonophagocytic assays. The 19F wzy variants displayed similar susceptibility to anti-19F IgG antibodies compared to standard 19F isolates. Our findings indicate that these 19F variants may be more common than previously believed

Electrospun PHEA-PLA/PCL Scaffold for Vascular Regeneration: A Preliminary in\ua0Vivo Evaluation

Background. There is increasing interest in the development of vessel substitutes, and many studies are currently focusing on the development of biodegradable scaffolds capable of fostering vascular regeneration. We tested a new biocompatible and biodegradable material with mechanical properties similar to those of blood vessels. Methods. The material used comprises a mixture of a,b-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and polylactic acid (PLA), combined with polycaprolactone (PCL) by means of electrospinning technique. Low-molecular-weight heparin was also linked to the copolymer. A tubular PHEA-PLA/PCL sample was used to create an arteriovenous fistula in a pig model with the use of the external iliac vessels. The flow was assessed by means of Doppler ultrasound examination weekly, and 1 month after the implantation we removed the scaffold for histopathologic evaluation. Results. The implants showed a perfect leak-proof seal and adequate elastic tension to blood pressure. About w3 weeks after the implantation, Doppler examination revealed thrombosis of the graft, so we proceeded to its removal. Histologic examination showed chronic inflammation, with the presence of foreign body cells and marked neovascularization. The material had been largely absorbed, leaving some isolated spot residues. Conclusions. The biocompatibility of PHEA-PLA/PCL and its physical properties make it suitable for the replacement of vessels. In the future, the possibility of functionalizing the material with a variety of molecules, to modulate the inflammatory and coagulative responses, will allow obtaining devices suitable for the replacement of native vessels

Improved Bone Regeneration Using Biodegradable Polybutylene Succinate Artificial Scaffold in a Rabbit Model

The treatment of extensive bone loss represents a great challenge for orthopaedic and reconstructive surgery. Most of the time, those treatments consist of multiple-stage surgeries over a prolonged period, pose significant infectious risks and carry the possibility of rejection. In this study, we investigated if the use of a polybutylene succinate (PBS) micro-fibrillar scaffold may improve bone regeneration in these procedures. In an in vivo rabbit model, the healing of two calvarial bone defects was studied. One defect was left to heal spontaneously while the other was treated with a PBS scaffold. Computed tomography (CT) scans, histological and immunohistochemical analyses were performed at 4, 12 and 24 weeks. CT examination showed a significantly larger area of mineralised tissue in the treated defect. Histological examination confirmed a greater presence of active osteoblasts and mineralised tissue in the scaffold-treated defect, with no evidence of inflammatory infiltrates around it. Immunohistochemical analysis was positive for CD56 at the transition point between healthy bone and the fracture zone. This study demonstrates that the use of a PBS microfibrillar scaffold in critical bone defects on a rabbit model is a potentially effective technique to improve bone regeneration