Integrating Information Literacy into the Virtual University: A Course Model

published or submitted for publicatio

Quantitative Analysis of Electrotonic Structure and Membrane Properties of NMDA-Activated Lamprey Spinal Neurons

Parameter optimization methods were used to quantitatively analyze frequency-domain-voltage-clamp data of NMDA-activated lamprey spinal neurons simultaneously over a wide range of membrane potentials. A neuronal cable model was used to explicitly take into account receptors located on the dendritic trees. The driving point membrane admittance was measured from the cell soma in response to a Fourier synthesized point voltage clamp stimulus. The data were fitted to an equivalent cable model consisting of a single lumped soma compartment coupled resistively to a series of equal dendritic compartments. The model contains voltage-dependent NMDA sensitive (INMDA), slow potassium (IK), and leakage (IL) currents. Both the passive cable properties and the voltage dependence of ion channel kinetics were estimated, including the electrotonic structure of the cell, the steady-state gating characteristics, and the time constants for particular voltage- and time-dependent ionic conductances. An alternate kinetic formulation was developed that consisted of steady-state values for the gating parameters and their time constants at half-activation values as well as slopes of these parameters at half-activation. This procedure allowed independent restrictions on the magnitude and slope of both the steady-state gating variable and its associated time constant. Quantitative estimates of the voltage-dependent membrane ion conductances and their kinetic parameters were used to solve the nonlinear equations describing dynamic responses. The model accurately predicts current clamp responses and is consistent with experimentally measured TTX-resistant NMDA-induced patterned activity. In summary, an analysis method is developed that provides a pragmatic approach to quantitatively describe a nonlinear neuronal system

A Profile of Smoking and Health in Wales

No abstract available

Hypersonic test facility Patent

Hypersonic test facility for studying ablation in models under high pressure and high temperatur

The continuous strength method for the design of circular hollow sections

Circular hollow sections (CHS) are widely used in a range of structural engineering applications. Their design is covered by all major design codes, which currently use elastic, perfectly-plastic material models and cross-section classification to determine cross-secti\on compressive and flexural resistances. Experimental data for stocky sections show that this can result in overly conservative estimates of cross-section capacity. The continuous strength method (CSM) has been developed to reflect better the observed behaviour of structural sections of different metallic materials. The method is deformation based and allows for the rational exploitation of strain hardening. In this paper, the CSM is extended to cover the design of non-slender and slender structural steel, stainless steel and aluminium CHS, underpinned by and validated against 342 stub column and bending test results. Comparisons with the test results show that, overall, the CSM on average offers more accurate and less scattered predictions of axial and flexural capacities than existing design methods

WFPC2 LRF Imaging of Emission Line Nebulae in 3CR Radio Galaxies

We present HST/WFPC2 Linear Ramp Filter images of high surface brightness emission lines (either [OII], [OIII], or H-alpha+[NII]) in 80 3CR radio sources. We overlay the emission line images on high resolution VLA radio images (eight of which are new reductions of archival data) in order to examine the spatial relationship between the optical and radio emission. We confirm that the radio and optical emission line structures are consistent with weak alignment at low redshift (z < 0.6) except in the Compact Steep Spectrum (CSS) radio galaxies where both the radio source and the emission line nebulae are on galactic scales and strong alignment is seen at all redshifts. There are weak trends for the aligned emission line nebulae to be more luminous, and for the emission line nebula size to increase with redshift and/or radio power. The combination of these results suggests that there is a limited but real capacity for the radio source to influence the properties of the emission line nebulae at these low redshifts (z < 0.6). Our results are consistent with previous suggestions that both mechanical and radiant energy are responsible for generating alignment between the radio source and emission line gas.Comment: 80 pages, 54 figures. Accepted for publication in ApJ

Cold-formed stainless steel CHS beam-columns – testing, simulation and design

The present work was prompted by shortcomings identi ed in existing design provisions for stainless steel circular hollow section (CHS) beam-columns. First, addressing a lack of existing experimental data, a series of ferritic stainless steel CHS beam-column tests was undertaken at the cross-section and member levels. In total, 26 beam-column tests, including two section sizes (a non-slender class 3 and slender class 4 cross-section), two member slenderness values for each cross-section type and a wide range of loading eccentricities were carried out to investigate the interaction between local and global buckling. Following validation of nite element (FE) models, a numerical study was then undertaken to explore the buckling response of stainless steel CHS beam-columns, covering austenitic, duplex and ferritic grades with a wide range of local and global slendernesses and applied loading eccentricities. Over 2000 numerical results were generated and used to assess new design proposals for stainless steel beam-columns, featuring improved compression and bending end points and new interaction factors. The new proposals are more consistent and more accurate in their resistance predictions than the current EN 1993-1-4 (2015) design approach. The reliability of the new proposals has been veri ed by means of statistical analyses according to EN 1990 (2005)

Buying Design, Where are we now? Associate Parliamentary Design Innovation Group Term Paper

‘Design ...The purposeful move from a current situation to a preferred situation.’ – Herbert Simon In 2010 the Associate Parliamentary Design and Innovation Group (APDIG) published a report critiquing government procurement practice as it related to design services. The main accusation was that government too often tried to buy design as though it were a discrete commodity, rather than a creative service, and that this seriously hampered the ultimate outcome for both buyer and supplier. This paper brings an update on the state of design procurement, including the results of an industry consultation conducted by our partners on the initial report, the Design Business Association