16,676 research outputs found
Fundamental Behavior of Electric Field Enhancements in the Gaps Between Closely Spaced Nanostructures
We demonstrate that the electric field enhancement that occurs in a gap
between two closely spaced nanostructures, such as metallic nanoparticles, is
the result of a transverse electromagnetic waveguide mode. We derive an
explicit semianalytic equation for the enhancement as a function of gap size,
which we show has a universal qualitative behavior in that it applies
irrespective of the material or geometry of the nanostructures and even in the
presence of surface plasmons. Examples of perfect electrically conducting and
Ag thin-wire antennas and a dimer of Ag spheres are presented and discussed.Comment: 9 pages and 4 figure
A randomised controlled study of an audiovisual patient information intervention on informed consent and recruitment to cancer clinical trials
Recruitment to cancer clinical trials needs to be improved, as does patient knowledge and understanding about clinical trials, in order for patients to make an informed choice about whether or not to take part. Audiovisual patient information (AVPI) has been shown to improve knowledge and understanding in various areas of practice, but there is limited information about its effect in the cancer clinical trial setting, particularly in relation to consent rates. In this study, 173 patients were randomised to receive either the AVPI, in addition to the standard trial-specific written information, or the written information alone. There was no difference in clinical trial recruitment rates between the two groups with similar study entry rates: 72.1% in the AVPI group and 75.9% in the standard information group. The estimated odds ratio for refusal (intervention/no intervention) was 1.19 (95% CI 0.55–2.58, P=0.661). Knowledge scores increased more in the AVPI group compared to the standard group (P=0.0072). The change in anxiety score between the arms was also statistically significant (P=0.011) with anxiety improving in the intervention arm more than in the no intervention arm. Audiovisual patient information was shown to be a useful tool in improving patient knowledge and anxiety, but further work is necessary in relation to its effect on clinical trial recruitment rates
Composite Reflective/Absorptive IR-Blocking Filters Embedded in Metamaterial Antireflection Coated Silicon
Infrared (IR) blocking filters are crucial for controlling the radiative
loading on cryogenic systems and for optimizing the sensitivity of bolometric
detectors in the far-IR. We present a new IR filter approach based on a
combination of patterned frequency selective structures on silicon and a thin
(50 thick) absorptive composite based on powdered reststrahlen
absorbing materials. For a 300 K blackbody, this combination reflects
50\% of the incoming light and blocks \textgreater 99.8\% of the total
power with negligible thermal gradients and excellent low frequency
transmission. This allows for a reduction in the IR thermal loading to
negligible levels in a single cold filter. These composite filters are
fabricated on silicon substrates which provide excellent thermal transport
laterally through the filter and ensure that the entire area of the absorptive
filter stays near the bath temperature. A metamaterial antireflection coating
cut into these substrates reduces in-band reflections to below 1\%, and the
in-band absorption of the powder mix is below 1\% for signal bands below 750
GHz. This type of filter can be directly incorporated into silicon refractive
optical elements
Synthesis of high-oxidation Y-Ba-Cu-O phases in superoxygenated thin films
It is known that solid-state reaction in high-pressure oxygen can stabilize
high-oxidation phases of Y-Ba-Cu-O superconductors in powder form. We extend
this superoxygenation concept of synthesis to thin films which, due to their
large surface-to-volume ratio, are more reactive thermodynamically. Epitaxial
thin films of grown by pulsed laser deposition are
annealed at up to 700 atm O and 900C, in conjunction with Cu
enrichment by solid-state diffusion. The films show clear formation of
and as well as regions
of and YBaCuO phases,
according to scanning transmission electron microscopy, x-ray diffraction and
x-ray absorption spectroscopy. Similarly annealed
powders show no phase conversion. Our results demonstrate a novel route of
synthesis towards discovering more complex phases of cuprates and other
superconducting oxides.Comment: Accepted for publication in Physical Review Material
HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents
The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers and, additionally, its pharmacological activation by one compound can reduce the toxicity or efficiency of a second agent administered concomitantly. In this work, we have analysed systematically the ability of 152 research, pre-clinical or clinically used drugs to induce an NRF2 response using the MCF7-AREc32 NRF2 reporter. Ten percent of the tested drugs induced an NRF2 response. The NRF2 activators were not restricted to classical cytotoxic alkylating agents but also included a number of emerging anticancer drugs, including an IGF1-R inhibitor (NVP-AEW541), a PIM-1 kinase inhibitor (Pim1 inhibitor 2), a PLK1 inhibitor (BI 2536) and most strikingly seven of nine tested HDAC inhibitors. These findings were further confirmed by demonstrating NRF2-dependent induction of endogenous AKR genes, biomarkers of NRF2 activity. The ability of HDAC inhibitors to stimulate NRF2-signalling did not diminish their own potency as antitumour agents. However, when used to pre-treat cells, they did reduce the efficacy of acrolein. Taken together, our data suggest that the ability of drugs to stimulate NRF2 activity is common and should be investigated as part of the drug-development process
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