Impact of supermassive black hole growth on star formation

Supermassive black holes are found at the centre of massive galaxies. During the growth of these black holes they light up to become visible as active galactic nuclei (AGN) and release extraordinary amounts of energy across the electromagnetic spectrum. This energy is widely believed to regulate the rate of star formation in the black holes' host galaxies via so-called "AGN feedback". However, the details of how and when this occurs remains uncertain from both an observational and theoretical perspective. I review some of the observational results and discuss possible observational signatures of the impact of super-massive black hole growth on star formation.Comment: Invited Review for Nature Astronomy - accepted for publication. 11 pages 6 figure

The impact of AGN on their host galaxies

In these proceedings I briefly: (1) review the impact (or "feedback") that active galactic nuclei (AGN) are predicted to have on their host galaxies and larger scale environment, (2) review the observational evidence for or against these predictions and (3) present new results on ionised outflows in AGN. The observational support for the "maintenance mode" of feedback is strong (caveat the details); AGN at the centre of massive halos appear to be regulating the cooling of hot gas, which could in turn control the levels of future star formation (SF) and black hole growth. In contrast, direct observational support for more rapid forms of feedback, which dramatically impact on SF (i.e., the "quasar mode"), remains elusive. From a systematic study of the spectra of approx. 24000 z<0.4 AGN we find that extreme ionised gas kinematics are common, and are most prevalent in radio bright AGN (L[1.4GHz] >10^23 W/Hz). Follow-up IFU observations have shown that these extreme gas kinematics are extended over kilo-parsec scales. However, the co-existence of high-levels of SF, luminous AGN activity and radio jets raises interesting questions on the primary drivers and impact of these outflows. Galaxy-wide, high-mass outflows are being observed in an increasing number of AGN and are a plausible mechanism for the depletion of gas; however, there is still much work to be done to determine the physical processes that drive these outflows and to measure the level of impact that they have on their host galaxies.Comment: Invited contribution to appear in: Proceedings of the IAU Symposium No. 304, "Multiwavelength AGN Surveys and Studies". 7 pages, 2 figure

Implications of cavity, topographic and geologic influences on tilt and strain observations

Tilt and strain observations are importantly (pathologically at the 100%, typically at the few 10s% level) affected by cavities, topography, and geological inhomogenities; gravity observation are practically unaffected. The traditional earth tide observatory and abandoned mine or tunnel is a very poor place to measure body tides because of the complicated cavities, topography and geology. Instead, the ideal site for observing the body tide is in flat terrain with horizontally layered, mechanically homogeneous geology. Strain will be measured with long surface- or trench-mounted laser strain meters and tilt with long, surface- or trench mounted liquid levels, or with borehole tiltmeters. Horizontal geological discontinuities can produce large perturbations of the tilt and strain tides, and these perturbations, using the known homogeneous tidal strains and tilts, can be used in exploring local structure in favorable cases and, through possible time variations of tidal admittances, in predicting earthquakes

Evaluation of the cardiovascular system during various circulatory stresses

Hardware and techniques for studying human circulatory performance in space environmen

Effects of simulated weightlessness on regional blood flow specifically during cardiovascular stress

Significant changes in the cardiovasular system of humans and animals have been observed following exposure to prolonged periods of weightlessness during space flight. Although adaption to weightlessness is relatively uncomplicated, marked changes in cardiovascular deconditioning become evident upon return to normal gravity, including orthostatic hypotension and tachycardia. Some evidence that myocardial degeneration occurs has been demonstrated in animals who have been immobilized for two months. Also, evidence of possible loss of myocardial mass following manned space flight has been obtained by means of echocardiographic studies. These findings have serious implications in light of the increasing frequency and duration of Space Shuttle missions and the prospect of extended space station missions in the future. A number of both military and civilian investigators, including middle-aged scientists, will probably encounter prolonged periods of weightlessness. It has been imperative, therefore, to determine the effects of prolonged weightlessness on cardiovascular deconditioning and whether such effects are cumulative or reversible. The research project conducted under NASA Cooperative Agreement NCC 2-126 was undertaken to determine the effects of prolonged simulated weightlessness on regional blood flow. Research results are reported in the three appended publications

Atmospheric hypoxia limits selection for large body size in insects

Recent geological models indicate a marked increase in atmospheric oxygen partial pressure (aPO~2~) to 32 kPa in the Permo-Carboniferous (approx. 300 million years ago), subsequently falling to 13 kPa in the Triassic^1^.These aPO~2~ changes have been hypothesized to cause multiple major evolutionary events^2^ including the appearance and subsequent extinction of giant insects and other taxa^3, 4^. Patterns of increasing tracheal investment in larger insects support this hypothesis^5^, as do observations of positive relationships between aPO~2~ and body size in single- or multi-generational experiments with _Drosophila melanogaster_ and other insects^6^. Large species likely result from many generations of selection for large body size driven by predation, competition or sexual selection^7^. Thus a crucial question is whether aPO~2~ influences the capacity of such selection to increase insect size. We tested that possibility by selecting for large body size in five _Drosophila melanogaster_ populations for 11 generations in hypoxic (10 kPa), normoxic (21 kPa) and hyperoxic (40 kPa) aPO~2~, followed by three generations of normoxia without size selection to test for evolved responses. Average body sizes increased by 15% during 11 generations of size selection in 21 and 40 kPa aPO~2~ flies and even stronger responses were observed for the flies in the largest quartile of body masses. However, flies selected for large size in 10 kPa aPO~2~ had strongly reduced sizes compared to those in higher aPO~2~. Upon return to normoxia, all flies had similar, enlarged sizes relative to the starting populations. These results demonstrated that positive size selection had equivalent genetic effects on all flies independent of aPO~2~, but that hypoxia provided a physical constraint on body size even in a relatively small insect under strong selection for larger mass. Our data support the hypothesis that Triassic hypoxia may have contributed to a reduction in insect size

Matching concepts across HOL libraries

Many proof assistant libraries contain formalizations of the same mathematical concepts. The concepts are often introduced (defined) in different ways, but the properties that they have, and are in turn formalized, are the same. For the basic concepts, like natural numbers, matching them between libraries is often straightforward, because of mathematical naming conventions. However, for more advanced concepts, finding similar formalizations in different libraries is a non-trivial task even for an expert. In this paper we investigate automatic discovery of similar concepts across libraries of proof assistants. We propose an approach for normalizing properties of concepts in formal libraries and a number of similarity measures. We evaluate the approach on HOL based proof assistants HOL4, HOL Light and Isabelle/HOL, discovering 398 pairs of isomorphic constants and types

Pharmacologic counter measures minimizing post-space flight orthostatic intolerance

The effect of bed rest on drug disposition and physiological function was investigated as part of a project to determine the cardiovascular effects of space flight. One group of subjects was given doses of lidocane, penicillin-G, and ICG during a control period and following seven days of bed rest. Cardiac function was evaluated by echo-cardiography. Renal function was evaluated in a second group before and after several days of bed rest. Inulin, para-aminohippurate, and dextran clearances were studied. In the first group, the post-bed rest parameters were not statistically different from the pre-bed rest valves. In the second study, renal function did not change significantly after seven days of bed rest. Plans for future research are reviewed

Strategy for discovering a low-mass Higgs boson at the Fermilab Tevatron

We have studied the potential of the CDF and DZero experiments to discover a low-mass Standard Model Higgs boson, during Run II, via the processes $p\bar{p}$ -> WH -> $\ell\nu b\bar{b}$, $p\bar{p}$ -> ZH -> $\ell^{+}\ell^{-}b\bar{b}$ and $p\bar{p}$ -> ZH ->$\nu \bar{\nu} b\bar{b}$. We show that a multivariate analysis using neural networks, that exploits all the information contained within a set of event variables, leads to a significant reduction, with respect to {\em any} equivalent conventional analysis, in the integrated luminosity required to find a Standard Model Higgs boson in the mass range 90 GeV/c**2 < M_H < 130 GeV/c**2. The luminosity reduction is sufficient to bring the discovery of the Higgs boson within reach of the Tevatron experiments, given the anticipated integrated luminosities of Run II, whose scope has recently been expanded.Comment: 26 pages, 8 figures, 7 tables, to appear in Physical Review D, Minor fixes and revision