Kwaliteit van de arbeid in pluimveehouderijsystemen als alternatief voor de legbatterij

Doel van het project is het beoordelen van de kwaliteit van de arbeid in de belangrijkste momenteel bekende huisvestingssystemen voor leghennen (inclusief de batterijhuisvesting). Op basis van deze integrale beoordeling van de arbeidskwaliteit zullen de gezondheidskundige implicaties voor de werkende mensen in elk van die huisvestingssystemen worden aangegeve

It\u27s all in the lens: Differences in views on obesity prevention between advocates and policy makers

Background: Intervention strategies to reduce obesity include policy and environmental changes that are designed to provide opportunities, support, and cues to help people develop healthier behaviors. Policy changes at the state level are one way to influence access, social norms, and opportunities for better nutrition and increased physical activity among the population. Methods: Ten states were selected for a broad variance in obesity rates and number of enacted obesity prevention policies during the years of 2006–2009. Within the selected states, a purely qualitative study of attitudes of childhood obesity policy using semistructured telephone interviews was conducted. Interviews were conducted with state policy makers who serve on public health committees. A set of six states that had more than eight childhood obesity policies enacted were selected for subsequent qualitative interviews with a convenience sample of well-established advocates. Results: Policy makers in states where there was more childhood obesity policy action believed in the evidence behind obesity policy proposals. Policy makers also varied in the perception of obesity as a constituent priority. The major differences between advocates and policy makers included a disconnect in information dissemination, opposition, and effectiveness of these policies. Conclusions: The findings from this study show differences in perceptions among policy makers in states with a greater number of obesity prevention bills enacted. There are differences among policy makers and advocates regarding the role and effectiveness of state policy on obesity prevention. This presents an opportunity for researchers and practitioners to improve communication and translation of evidence to policy makers, particularly in states with low legislation

The development of thirty self-administering and self-scoring elaborative thinking exercises

Thesis (Ed.M.)--Boston Universit

Educational Effects of a Vocabulary Intervention on Preschoolers' Word Knowledge and Conceptual Development: A Cluster‐Randomized Trial

The purpose of this study was to examine the hypothesis that helping preschoolers learn words through categorization may enhance their ability to retain words and their conceptual properties, acting as a bootstrap for self‐learning. We examined this hypothesis by investigating the effects of the World of Words instructional program, a supplemental intervention for children in preschool designed to teach word knowledge and conceptual development through taxonomic categorization and embedded multimedia. Participants in the study included 3‐ and 4‐year‐old children from 28 Head Start classrooms in 12 schools, randomly assigned to treatment and control groups. Children were assessed on word knowledge, expressive language, conceptual knowledge, and categories and properties of concepts in a yearlong intervention. Results indicated that children receiving the WOW treatment consistently outperformed their control counterparts; further, treatment children were able to use categories to identify the meaning of novel words. Gains in word and categorical knowledge were sustained six months later for those children who remained in Head Start. These results suggest that a program targeted to learning words within taxonomic categories may act as a bootstrap for self‐learning and inference generation. كان الغرض من هذه الدراسة هو فحص فرضية أن مساعدة الأطفال في الروضة تعلم كلمات عن طريق التصنيف بإمكانه أن يعزز من قدراتهم على تذكر الكلمات وخصائصها المفاهيمية، بوصفها محفزا للتعلم. قمنا بفحص هذه الفرضية وذلك بالتحقيق في أثر البرنامج التعليمي "عالم المفردات" (WOW) الذي يعتبر تدخلا تكميليا لأطفال الروضة ومصمما من أجل تعليم معرفة الكلمات والتطور المفاهيمي، من خلال النظام التصنيفي ووسائل الإعلام. تضمنت الدراسة مشاركين تتراوح أعمارهم بين 3 و4 سنوات ينتمون إلى 28 روضة أطفال، التي تنتمي إلى 12 مدرسة, خضعت عشوائيا للبحث ومراقبة المجموعات. جرى تقييم الأطفال على معرفة الكلمات واللغة التعبيرية والمعرفة المفاهيمية وأصناف وخصائص المفاهيم في تدخل لمدة سنة كاملة. أظهرت النتائج أن الأطفال الذين خضعوا للبرنامج التعليمي "عالم المفردات" (WOW) قد تفوقوا بصورة مستمرة على نظرائهم الذين خضعوا للمراقبة. علاوة على ذلك, فإن أطفال البحث قد تمكنوا من استخدام الأصناف والتعرف على معنى الكلمات الجديدة. استمر اكتساب الكلمات والمعرفة التصنيفية بعد 6 أشهر بالنسبة للأطفال الذين بقوا في روضة الأطفال. توحي هذه النتائج إلى أنه يمكن لبرنامج يهدف إلى تعلم الكلمات أن يعمل كمحفز للتعلم الذاتي، وتوليد الاستنتاجات. 本研究旨在考查一个假设：帮助学龄前儿童通过分类来学习单词，可提高他们记忆单词及其概念属性的能力，从而发展他们的自主学习能力。作者通过调查「单词世界」(WOW)教学计划的影响来考查这个假设。该教学计划是一个学龄前儿童补充干预计划，旨在透过使用分类学的分类方法及嵌入式多媒体，教授单词知识和发展单词概念。研究参与者是来自12所学校中的28个「启蒙计划」学前儿童班里的3‐4岁儿童，他们被随机分配到干预组和对照组。在一年的干预中，儿童接受单词知识、表达语言、概念知识、类别和概念属性的评估。结果显示，「单词世界」(WOW)干预组的表现一致地优于对照组；此外，干预组儿童可以使用类别来确定新词的词义。仍然留在「启蒙计划」班里的儿童，其单词和类别知识的改进保持稳定至干预后6个月。这些研究结果显示，针对透过分类学的分类方法来学习单词的教学计划，可引导儿童凭自己的力量学习自学和产生推断。 Cette étude avait pour but d'examiner l'hypothíse qu'aider des enfants d'âge préscolaire à apprendre des mots en les catégorisant pourrait favoriser leur capacité à retenir les mots et leurs propriétés, agissant alors comme une amorce d'auto‐apprentissage. Nous avons examiné cette hypothíse en analysant les effets du matériel d'enseignement le Monde des Mots (MDM), un supplément pédagogique destiné aux enfants d'âge préscolaire conçu pour la connaissance des mots et le développement des concepts à l'aide d'une catégorisation taxinomique avec multimédia impliqué. Ont participé à l'étude des enfants de 3 et 4 ans provenant de 28 classes Head Start issus de 12 écoles assignées au hasard au groupe de traitement et au groupe contrôle. Les enfants ont été évalués sur leur connaissance des mots, l'expression orale, les connaissances conceptuelles, les catégories et les propriétés des concepts tout au long de l'année de l'intervention. Les résultats ont montré que les enfants du groupe de traitement MDM ont de maniíre systématique dépassé leur contrepartie du groupe contrôle; en outre, les enfants soumis au traitement ont été en mesure de se servir des catégories pour trouver le sens des mots nouveaux. Les bénéfices dans la connaissance des mots et les connaissances catégorielles sont demeurés six mois plus tard chez les enfants restés dans Head Start. Ces résultats suggírent qu'un programme visant l'apprentissage de mots au sein de catégories taxonomiques peut agir comme une amorce pour l'auto‐apprentissage et la production d'inférences. Проверялась гипотеза о том, что категоризация лексики при обучении дошкольников новым словам может существенно увеличить способность к запоминанию слов и их концептуальных свойств и стимулировать малышей к самообучению. Для расширения их словарного запаса и умения работать с концептами авторы исследовали учебный модуль “Мир слов” (WOW), разработанный в качестве дополнительного вмешательства для дошкольников, которые обучаются по программе Head Start. WOW знакомит детей с таксономической классификацией посредством мультимедийных средств. Трех‐ и четырехлетние дети из 28‐и дошкольных групп в 12‐и школах были случайным образом включены либо в экспериментальную, либо в контрольную группу. На протяжении годичного обучения оценивалось знание слов, выразительность речи, знание концептов, их свойств и категорий, к которым они могут быть причислены. Дети, обучавшиеся по программе WOW, стабильно показывали более высокие результаты, чем их ровесники из контрольных групп. Помимо прочего, эти дети способны использовать категоризацию для определения значений новых слов. Через полгода после окончания обучения эти дети продолжали опережать сверстников по знанию слов и умению категоризировать. Это свидетельствует о том, что программа, предлагающая изучение слов в рамках таксономических категорий, может помочь вырастить поколение, которое будет способно к самообучению и к самостоятельным выводам. La meta de este estudio fue el de investigar la hipótesis que ayudar a los preescolares a aprender palabras por medio de la categorización mejoraría su capacidad de retener palabras y sus propiedades conceptuales, sirviendo de arranque para el auto aprendizaje. Investigamos esta hipótesis estudiando los efectos del programa de enseñanza World of Words (Mundo de palabras; WOW por sus siglas en inglés), una intervención adicional para niños preescolares diseñada para el aprendizaje de palabras y el desarrollo conceptual por medio de la categorización taxonómica y el uso de diversos medios. En este estudio participaron niños de 3 y 4 años de 20 aulas de Head Start en 12 escuelas escogidas al azar en cuanto a grupos de tratamiento y de control. En un año completo de intervención, se evaluaron los estudiantes en cuanto a su conocimiento de palabras, su lenguaje expresivo, su conocimiento conceptual, y las categorías y propiedades de los conceptos. Los resultados mostraron que los niños del grupo de WOW sistemáticamente superaban a los niños del grupo de control; además, los niños del grupo de tratamiento podían usar categorías para encontrar el significado de palabras nuevas. Los adelantos en el conocimiento de palabras y categorías todavía existían 6 meses más tarde para los niños que seguían con Head Start. Estos resultados sugieren que un programa dedicado al aprendizaje de palabras dentro de categorías taxonómicas puede ayudar al autoaprendizaje y la producción de inferencias.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/88072/1/RRQ.46.3.3.pd

Distinguishing step relaxation mechanisms via pair correlation functions

Theoretical predictions of coupled step motion are tested by direct STM measurement of the fluctuations of near-neighbor pairs of steps on Si(111)-root3 x root3 R30 - Al at 970K. The average magnitude of the pair-correlation function is within one standard deviation of zero, consistent with uncorrelated near-neighbor step fluctuations. The time dependence of the pair-correlation function shows no statistically significant agreement with the predicted t^1/2 growth of pair correlations via rate-limiting atomic diffusion between adjacent steps. The physical considerations governing uncorrelated step fluctuations occurring via random attachment/detachment events at the step edge are discussed.Comment: 17 pages, 4 figure

Obesity and the food environment: income and ethnicity differences among people with diabetes: the Diabetes Study of Northern California (DISTANCE).

ObjectiveIt is unknown whether any association between neighborhood food environment and obesity varies according to individual income and/or race/ethnicity. The objectives of this study were to test whether there was an association between food environments and obesity among adults with diabetes and whether this relationship differed according to individual income or race/ethnicity.Research design and methodsSubjects (n = 16,057) were participants in the Diabetes Study of Northern California survey. Kernel density estimation was used to create a food environment score for each individual's residence address that reflected the mix of healthful and unhealthful food vendors nearby. Logistic regression models estimated the association between the modeled food environment and obesity, controlling for confounders, and testing for interactions between food environment and race/ethnicity and income.ResultsThe authors found that more healthful food environments were associated with lower obesity in the highest income groups (incomes 301-600% and >600% of U.S. poverty line) among whites, Latinos, and Asians. The association was negative, but smaller and not statistically significant, among high-income blacks. On the contrary, a more healthful food environment was associated with higher obesity among participants in the lowest-income group (<100% poverty threshold), which was statistically significant for black participants in this income category.ConclusionsThese findings suggest that the availability of healthful food environments may have different health implications when financial resources are severely constrained

AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury.

Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms. Peripheral nociceptive stimuli induce maladaptive synaptic plasticity in dorsal horn sensory systems through AMPA receptor (AMPAR) phosphorylation and trafficking to synapses. Here we test whether ventral horn motor neurons in rats demonstrate similar experience-dependent maladaptive plasticity below a complete SCI in vivo. Quantitative biochemistry demonstrated that intermittent nociceptive stimulation (INS) rapidly and selectively increases AMPAR subunit GluA1 serine 831 phosphorylation and localization to synapses in the injured spinal cord, while reducing synaptic GluA2. These changes predict motor dysfunction in the absence of cell death signaling, suggesting an opportunity for therapeutic reversal. Automated confocal time-course analysis of lumbar ventral horn motor neurons confirmed a time-dependent increase in synaptic GluA1 with concurrent decrease in synaptic GluA2. Optical fractionation of neuronal plasma membranes revealed GluA2 removal from extrasynaptic sites on motor neurons early after INS followed by removal from synapses 2 h later. As GluA2-lacking AMPARs are canonical calcium-permeable AMPARs (CP-AMPARs), their stimulus- and time-dependent insertion provides a therapeutic target for limiting calcium-dependent dynamic maladaptive plasticity after SCI. Confirming this, a selective CP-AMPAR antagonist protected against INS-induced maladaptive spinal plasticity, restoring adaptive motor responses on a sensorimotor spinal training task. These findings highlight the critical involvement of AMPARs in experience-dependent spinal cord plasticity after injury and provide a pharmacologically targetable synaptic mechanism by which early postinjury experience shapes motor plasticity

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.

Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood. Interestingly, recent human genetic studies have implicated the endosomal Na+/H+ exchanger NHE9 in both autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). Plasma membrane NHEs regulate cytosolic pH, but the role of intracellular isoforms has remained unclear. We now find that inactivation of NHE9 in mice reproduces behavioral features of ASD including impaired social interaction, repetitive behaviors, and altered sensory processing. Physiological characterization reveals hyperacidic endosomes, a cell-autonomous defect in glutamate receptor expression and impaired neurotransmitter release due to a defect in presynaptic Ca2+ entry. Acute inhibition of synaptic vesicle acidification rescues release but without affecting the primary defect due to loss of NHE9

Improving dietary intake during lunch through the provision of a healthy school lunch at Dutch primary schools : Design of a pretest-posttest effectiveness study

Background: Since there is a shift from eating lunch at home to eating lunch at primary schools in the Netherlands, providing a school lunch may be an important opportunity to improve the diet quality of Dutch children. Therefore, the aim of this Healthy School Lunch project is to encourage healthy eating behavior of children at primary schools by offering a healthy school lunch, based on the guidelines for a healthy diet. In this study, two research questions will be addressed. The first research question is: What and how much do children consume from a self-served school lunch and how do they evaluate the lunch? The second research question is: Do children compensate healthier school lunches by eating less healthy outside school hours? The purpose of this paper is to report the rationale and study design of this study. Methods: In the Healthy School Lunch project children in grades 5-8 (aged 8-12 years) of three primary schools in the Netherlands will receive a healthy school lunch for a 6-month period. To answer research question 1, lunch consumption data will be collected at baseline and again at 3- A nd 6-months. This will be measured with lunch photos and questionnaires among children. To answer the second research question, a quasi-experimental, pre-test post-test intervention-comparison group design (3 intervention schools and 3 comparison schools) will be carried out. Potential compensation effects will be measured with a single brief questionnaire among parents at the three intervention and three comparison schools at month 6 of the lunch period. The school lunch will also be evaluated by parents (discussion groups) and teachers and support staff (brief questionnaires). Discussion: Results of this study will provide valuable information to influence future school lunch interventions and policies. Trial registration: This study is registered at the Netherlands trial register (NTR): Trialregister.nl, Trial NL7402 (NTR7618), registered retrospectively at 2018-11-13.</p