Structural load challenges during space shuttle development

The challenges that resulted from the unique configuration of the space shuttle and capabilities developed to meet these challenges are described. The methods and the organization that were developed to perform dynamic loads analyses on the space shuttle configuration and to assess dynamic data developed after design are discussed. Examples are presented from the dynamic loads analysis of the lift-off and maximum dynamic pressure portion of ascent. Also shown are orbital flight test results, for which selected predicted responses are compared to measured data for the lift-off and high-dynamic-pressure times of ascent. These results have generally verified the design analysis. However, subscale testing was found to be deficient in predicting full-scale results in two areas: the ignition overpressure at lift-off and the aerodynamics/plume interactions at high-q boost. In these areas, the results of the flight test program were accommodated with no impact to the vehicle design

Hot Quark Matter with an Axial Chemical Potential

We analyze the phase diagram of hot quark matter in presence of an axial chemical potential, $\mu_5$. The latter is introduced to mimic the chirality transitions induced, in hot Quantum Chromodynamics, by the strong sphaleron configurations. In particular, we study the curvature of the critical line at small $\mu_5$, the effects of a finite quark mass and of a vector interaction. Moreover, we build the mixed phase at the first order phase transition line, and draw the phase diagram in the chiral density and temperature plane. We finally compute the full topological susceptibility in presence of a background of topological charge.Comment: 12 pages, 7 figures. Few references added, short discussion included. Final version appearing on Phys. Rev.

Peptide self‐assembled nanostructures: from models to therapeutic peptides

: Self-assembly is the most suitable approach to obtaining peptide-based materials on the nano- and mesoscopic scales. Applications span from peptide drugs for personalized therapy to light harvesting and electron conductive media for solar energy production and bioelectronics, respectively. In this study, we will discuss the self-assembly of selected model and bioactive peptides, in particular reviewing our recent work on the formation of peptide architectures of nano- and mesoscopic size in solution and on solid substrates. The hierarchical and cooperative characters of peptide self-assembly will be highlighted, focusing on the structural and dynamical properties of the peptide building blocks and on the nature of the intermolecular interactions driving the aggregation phenomena in a given environment. These results will pave the way for the understanding of the still-debated mechanism of action of an antimicrobial peptide (trichogin GA IV) and the pharmacokinetic properties of a peptide drug (semaglutide) currently in use for the therapy of type-II diabetes

Casting Ballots When Knowing Results

Access to information about candidates' performance has long stood as a key factor shaping voter behaviour, but establishing how it impacts behaviour in real-world settings has remained challenging. In the 2018 Brazilian presidential elections, unpredictable technical glitches caused by the implementation of biometrics as a form of identification led some voters to cast ballots after official tallies started being announced. In addition to providing a source of exogenous variation of information exposure, run-off elections also enable us to distinguish between different mechanisms underlying the impact of information exposure. We find strong support for a vote-switching bandwagon effect: information exposure motivates voters to abandon losing candidates and switch support for the frontrunner – a finding that stands in the second round, when only two candidates compete against each other. These findings provide theoretical nuance and stronger empirical support for the mechanisms underpinning the impact of information exposure on voter behaviour

Assessing the Applicability of the GTR Nucleotide Substitution Model Through Simulations

The General Time Reversible (GTR) model of nucleotide substitution is at the core of many distance-based and character-based phylogeny inference methods. The procedure described by Waddell and Steel (1997), for estimating distances and instantaneous substitution rate matrices, R, under the GTR model, is known to be inapplicable under some conditions, ie, it leads to the inapplicability of the GTR model. Here, we simulate the evolution of DNA sequences along 12 trees characterized by different combinations of tree length, (non-)homogeneity of the substitution rate matrix R, and sequence length. We then evaluate both the frequency of the GTR model inapplicability for estimating distances and the accuracy of inferred alignments. Our results indicate that, inapplicability of the Waddel and Steel’s procedure can be considered a real practical issue, and illustrate that the probability of this inapplicability is a function of substitution rates and sequence length

Land use/vegetation mapping in reservoir management. Merrimack River basin

This report consists of an analysis of: ERTS-1 Multispectral Scanner imagery obtained 10 August 1973; Skylab 3 S190A and S190B photography, track 29, taken 21 September 1973; and RB-57 high-altitude aircraft photography acquired 26 September 1973. These data products were acquired on three cloud-free days within a 47-day period. The objectives of this study were: (1) to make quantitative comparisons between high-altitude aircraft photography and satellite imagery, and (2) to demonstrate the extent to which high resolution (S190A and B) space-acquired data can be used for land use/vegetation mapping and management of drainage basins

The SILCC (SImulating the LifeCycle of molecular Clouds) project: I. Chemical evolution of the supernova-driven ISM

The SILCC project (SImulating the Life-Cycle of molecular Clouds) aims at a more self-consistent understanding of the interstellar medium (ISM) on small scales and its link to galaxy evolution. We simulate the evolution of the multi-phase ISM in a 500 pc x 500 pc x 10 kpc region of a galactic disc, with a gas surface density of $\Sigma_{_{\rm GAS}} = 10 \;{\rm M}_\odot/{\rm pc}^2$. The Flash 4.1 simulations include an external potential, self-gravity, magnetic fields, heating and radiative cooling, time-dependent chemistry of H$_2$ and CO considering (self-) shielding, and supernova (SN) feedback. We explore SN explosions at different (fixed) rates in high-density regions (peak), in random locations (random), in a combination of both (mixed), or clustered in space and time (clustered). Only random or clustered models with self-gravity (which evolve similarly) are in agreement with observations. Molecular hydrogen forms in dense filaments and clumps and contributes 20% - 40% to the total mass, whereas most of the mass (55% - 75%) is in atomic hydrogen. The ionised gas contributes <10%. For high SN rates (0.5 dex above Kennicutt-Schmidt) as well as for peak and mixed driving the formation of H$_2$ is strongly suppressed. Also without self-gravity the H$_2$ fraction is significantly lower ($\sim$ 5%). Most of the volume is filled with hot gas ($\sim$90% within $\pm$2 kpc). Only for random or clustered driving, a vertically expanding warm component of atomic hydrogen indicates a fountain flow. Magnetic fields have little impact on the final disc structure. However, they affect dense gas ($n\gtrsim 10\;{\rm cm}^{-3}$) and delay H$_2$ formation. We highlight that individual chemical species, in particular atomic hydrogen, populate different ISM phases and cannot be accurately accounted for by simple temperature-/density-based phase cut-offs.Comment: 30 pages, 23 figures, submitted to MNRAS. Comments welcome! For movies of the simulations and download of selected Flash data see the SILCC website: http://www.astro.uni-koeln.de/silc

Skylab imagery: Application to reservoir management in New England

The author has identified the following significant results. S190B imagery is superior to the LANDSAT imagery for land use mapping and is as useful for level 1 and 2 land use mapping as the RB-57/RC8 high altitude imagery. Detailed land use mapping at levels 3 and finer from satellite imagery requires better resolution. For evaluating factors that are required to determine volume runoff potentials in a watershed, the S190B imagery was found to be as useful as the RB-57/RC8 high altitude aircraft imagery

On the neutrality issue in the Polyakov-loop NJL model

We elucidate how the color neutrality is harmed in the Polyakov Nambu-Jona Lasinio (PNJL) model at finite density within the adopted mean field approximation. Also we point out how usual assumption about the diagonal form of the Wilson loop may fail in the presence of the diquark condensate on several grounds.Comment: 8 pages, 1 figure. Introduction enlarged, several comments about the adopted mean field approximation and the relation with Elitzur's theorem added. Version to appear on Phys. Rev.