Deixis social en la relación Odiseo/Iro en Odisea 18.1-157

El enfrentamiento entre Odiseo e Iro ha sido usualmente interpretado como una secuencia más en el itinerario de violencia que debe sufrir Odiseo hasta su restauración como basiléus. El presente artículo realiza una lectura descriptiva y analítica de los deícticos utilizados en el combate Odiseo/Iro; así como de la escena consecuente que le sigue. Ambos personajes hablan desde una posición social ajena al espacio en el que se inscriben y el campo verbal que generan resulta el recipiente de una lectura de clases sociales en Odisea. Analizaremos cómo las diversas categorías de la deixis - personal, temporal, espacial y discursiva- inciden en la deixis social que el texto de Odisea 18.1-157 expone.The fight between Odysseus and Irus has been usually interpreted as one more sequence in the itinerary of violence that Odysseus must suffer until his restoration as basileus. This article fulfils a descriptive and analytical study about the deixis used in the confrontation between Odysseus and Irus; it also studies the subsequent scene after the fight. Both characters speak from a social position not suitable to their proper space and their conversation shows an interpretation about the social classes of the Odyssey. We will analyze how several categories of deixis - personal, temporal, spatial and discoursive- influence the social deixis that the Odyssey exposes in Book 18.1-157.Fil: Zecchin de Fasano, Graciela C.. Universidad Nacional de La Plat

Playing on the dark side: Smyd3 acts as a cancer genome keeper in gastrointestinal malignancies

The SMYD3 methyltransferase has been found overexpressed in several types of cancers of the gastrointestinal (GI) tract. While high levels of SMYD3 have been positively correlated with cancer progression in cellular and advanced mice models, suggesting it as a potential risk and prognosis factor, its activity seems dispensable for autonomous in vitro cancer cell proliferation. Here, we present an in-depth analysis of SMYD3 functional role in the regulation of GI cancer progression. We first describe the oncogenic activity of SMYD3 as a transcriptional activator of genes involved in tumorigenesis, cancer development and transformation and as a co-regulator of key cancer-related pathways. Then, we dissect its role in orchestrating cell cycle regulation and DNA damage response (DDR) to genotoxic stress by promoting homologous recombination (HR) repair, thereby sustaining cancer cell genomic stability and tumor progression. Based on this evidence and on the involvement of PARP1 in other DDR mechanisms, we also outline a synthetic lethality approach consisting of the combined use of SMYD3 and PARP inhibitors, which recently showed promising therapeutic potential in HR-proficient GI tumors expressing high levels of SMYD3. Overall, these findings identify SMYD3 as a promising target for drug discovery

Intractable epilepsy in patients treated for childhood acute lymphocytic leukemia

AbstractPurposeIn the 1970s and 80s, standard treatment for childhood acute lymphocytic leukemia (ALL) included both intrathecal methotrexate and whole-brain irradiation. During acute treatment, seizures were not uncommon. The development of intractable epilepsy years after treatment, however, has not been well described in the literature. We describe five patients who were treated for acute lymphocytic leukemia as children, who later developed intractable epilepsy.ResultsAll of the patients were diagnosed with leukemia before age seven. Treatment included both whole-brain irradiation and intrathecal chemotherapy. All five received intrathecal methotrexate; in addition, two also received intrathecal cytosine arabinoside. The first seizure occurred at a mean of 7.5 years after diagnosis. Four patients have multiple seizure types, and all patients have been on multiple antiepileptic drugs. All five patients are cognitively impaired.ConclusionsSuccessful treatment for childhood leukemia may be followed by signs of late cerebral injury including intractable epilepsy. We propose that neurotoxicity resulting from exposure to intrathecal methotrexate and cranial irradiation may have contributed to the intractable epilepsy seen in our five patients

Strong-coupling analysis of scanning tunneling spectra in Bi2_2Sr2_2Ca2_2Cu3_3O10+δ_{10+\delta}

We study a series of spectra measured in the superconducting state of optimally-doped Bi-2223 by scanning tunneling spectroscopy. Each spectrum, as well as the average of spectra presenting the same gap, is fitted using a strong-coupling model taking into account the band structure, the BCS gap, and the interaction of electrons with the spin resonance. After describing our measurements and the main characteristics of the strong-coupling model, we report the whole set of parameters determined from the fits, and we discuss trends as a function of the gap magnitude. We also simulate angle-resolved photoemission spectra, and compare with recent experimental results.Comment: Published versio

Differential cross section analysis in kaon photoproduction using associated legendre polynomials

Angular distributions of differential cross sections from the latest CLAS data sets \cite{bradford}, for the reaction ${\gamma}+p {\to} K^{+} + {\Lambda}$ have been analyzed using associated Legendre polynomials. This analysis is based upon theoretical calculations in Ref. \cite{fasano} where all sixteen observables in kaon photoproduction can be classified into four Legendre classes. Each observable can be described by an expansion of associated Legendre polynomial functions. One of the questions to be addressed is how many associated Legendre polynomials are required to describe the data. In this preliminary analysis, we used data models with different numbers of associated Legendre polynomials. We then compared these models by calculating posterior probabilities of the models. We found that the CLAS data set needs no more than four associated Legendre polynomials to describe the differential cross section data. In addition, we also show the extracted coefficients of the best model.Comment: Talk given at APFB08, Depok, Indonesia, August, 19-23, 200

The WINGS Survey: a progress report

A two-band (B and V) wide-field imaging survey of a complete, all-sky X-ray selected sample of 78 clusters in the redshift range z=0.04-0.07 is presented. The aim of this survey is to provide the astronomical community with a complete set of homogeneous, CCD-based surface photometry and morphological data of nearby cluster galaxies located within 1.5 Mpc from the cluster center. The data collection has been completed in seven observing runs at the INT and ESO-2.2m telescopes. For each cluster, photometric data of about 2500 galaxies (down to V~23) and detailed morphological information of about 600 galaxies (down to V~21) are obtained by using specially designed automatic tools. As a natural follow up of the photometric survey, we also illustrate a long term spectroscopic program we are carrying out with the WHT-WYFFOS and AAT-2dF multifiber spectrographs. Star formation rates and histories, as well as metallicity estimates will be derived for about 350 galaxies per cluster from the line indices and equivalent widths measurements, allowing us to explore the link between the spectral properties and the morphological evolution in high- to low-density environments, and across a wide range in cluster X-ray luminosities and optical properties.Comment: 12 pages, 10 eps figures, Proceedings of the SAIt Conference 200

The Assembly of Diversity in the Morphologies and Stellar Populations of High-Redshift Galaxies

We have studied the evolution in the morphologies, sizes, stellar-masses, colors, and internal color dispersion (ICD) of galaxies at z=1 and 2.3, using a near-IR, flux-limited catalog for the HDF-N. At z=1 most luminous galaxies have morphologies of early-to-mid Hubble-types, and many show transformations between their rest-frame UV-optical morphologies. Galaxies at z=2.3 have compact and irregular morphologies with no clearly evident Hubble-sequence candidates. The mean galaxy size grows from z=2.3 to 1 by 40%, and the density of galaxies larger than 3 kpc increases by 7 times. At z=1, the size-luminosity distribution is broadly consistent with that of local galaxies, with passive evolution. However, galaxies at z=2.3 are smaller than the large present-day galaxies, and must continue to grow in size and stellar mass. We have measured the galaxies' UV-optical ICD, which quantifies differences in morphology and the relative amount of on-going star-formation. The mean and scatter in galaxies' total colors and ICD increase from z=2.3 to 1. At z=1 many galaxies with large ICD are spirals, with a few irregular systems. Few z=2.3 galaxies have high ICD, and those that do are actively merging. We interpret this as evidence for the presence of older and more diverse stellar populations at z=1 that are not generally present at z>2. We conclude that the star-formation histories of galaxies at z>2 are dominated by discrete, recurrent bursts, which quickly homogenize the galaxies' stellar content, and are possibly associated with mergers. The increase in the stellar-population diversification by z<1.4 implies that merger-induced starbursts occur less frequently than at higher redshifts, and more quiescent star-forming modes dominate. This transition coincides with the emergence of Hubble-sequence galaxies. [Abridged]Comment: Accepted for publication in the Astrophysical Journal. 20 pages, in emulateapj forma

Superclustering at Redshift Z=0.54

We present strong evidence for the existence of a supercluster at a redshift of z=0.54 in the direction of Selected Area 68. From the distribution of galaxies with spectroscopic redshifts we find that there is a large over-density of galaxies (a factor of four over the number expected in an unclustered universe) within the redshift range 0.530 < z < 0.555. By considering the spatial distribution of galaxies within this redshift range (using spectroscopic and photometric redshifts) we show that the galaxies in SA68 form a linear structure passing from the South-West of the survey field through to the North-East (with a position angle of approximately 35 deg East of North). This position angle is coincident with the positions of the X-ray clusters CL0016+16, RX J0018.3+1618 and a new X-ray cluster, RX J0018.8+1602, centered near the radio source 54W084. All three of these sources are at a redshift of approximately z=0.54 and have position angles, derived from their X-ray photon distributions, consistent with that measured for the supercluster. Assuming a redshift of 0.54 for the distribution of galaxies and a FWHM dispersion in redshift of 0.020 this represents a coherent structure with a radial extent of 31 Mpc, transverse dimension of 12 Mpc, and a thickness of approximately 4 Mpc. The detection of this possible supercluster demonstrates the power of using X-ray observations, combined with multicolor observations, to map the large scale distribution of galaxies at intermediate redshifts.Comment: 12 pages, 3 figures, Latex, aaspp4.sty, accepted for publication in Ap J Letters. Figure 3 and followup observations can be found at http://tarkus.pha.jhu.edu/~ajc/papers/supercluster