1,879 research outputs found
Evidence for a Weak Galactic Center Magnetic Field from Diffuse Low Frequency Nonthermal Radio Emission
New low-frequency 74 and 330 MHz observations of the Galactic center (GC)
region reveal the presence of a large-scale (6\arcdeg\times 2\arcdeg) diffuse
source of nonthermal synchrotron emission. A minimum energy analysis of this
emission yields a total energy of ergs
and a magnetic field strength of \muG (where is
the proton to electron energy ratio and is the filling factor of the
synchrotron emitting gas). The equipartition particle energy density is
\evcm, a value consistent with cosmic-ray data. However,
the derived magnetic field is several orders of magnitude below the 1 mG field
commonly invoked for the GC. With this field the source can be maintained with
the SN rate inferred from the GC star formation. Furthermore, a strong magnetic
field implies an abnormally low GC cosmic-ray energy density. We conclude that
the mean magnetic field in the GC region must be weak, of order 10 \muG (at
least on size scales \ga 125\arcsec).Comment: 12 pages, 1 JPEG figure, uses aastex.sty; Accepted for publication,
ApJL (2005, published
The equivalence of numbers: The social value of avoiding health decline: An experimental web-based study
BACKGROUND: Health economic analysis aimed at informing policy makers and supporting resource allocation decisions has to evaluate not only improvements in health but also avoided decline. Little is known however, whether the "direction" in which changes in health are experienced is important for the public in prioritizing among patients. This experimental study investigates the social value people place on avoiding (further) health decline when directly compared to curative treatments in resource allocation decisions. METHODS: 127 individuals completed an interactive survey that was published in the World Wide Web. They were confronted with a standard gamble (SG) and three person trade-off tasks, either comparing improvements in health (PTO-Up), avoided decline (PTO-Down), or both, contrasting health changes of equal magnitude differing in the direction in which they are experienced (PTO-WAD). Finally, a direct priority ranking of various interventions was obtained. RESULTS: Participants strongly prioritized improving patients' health rather than avoiding decline. The mean substitution rate between health improvements and avoided decline (WAD) ranged between 0.47 and 0.64 dependent on the intervention. Weighting PTO values according to the direction in which changes in health are experienced improved their accuracy in predicting a direct prioritization ranking. Health state utilities obtained by the standard gamble method seem not to reflect social values in resource allocation contexts. CONCLUSION: Results suggest that the utility of being cured of a given health state might not be a good approximation for the societal value of avoiding this health state, especially in cases of competition between preventive and curative interventions
The social value of a QALY : raising the bar or barring the raise?
Background: Since the inception of the National Institute for Health and Clinical Excellence (NICE) in England,
there have been questions about the empirical basis for the cost-per-QALY threshold used by NICE and whether
QALYs gained by different beneficiaries of health care should be weighted equally. The Social Value of a QALY
(SVQ) project, reported in this paper, was commissioned to address these two questions. The results of SVQ were
released during a time of considerable debate about the NICE threshold, and authors with differing perspectives
have drawn on the SVQ results to support their cases. As these discussions continue, and given the selective use of
results by those involved, it is important, therefore, not only to present a summary overview of SVQ, but also for
those who conducted the research to contribute to the debate as to its implications for NICE.
Discussion: The issue of the threshold was addressed in two ways: first, by combining, via a set of models, the
current UK Value of a Prevented Fatality (used in transport policy) with data on fatality age, life expectancy and
age-related quality of life; and, second, via a survey designed to test the feasibility of combining respondentsâ
answers to willingness to pay and health state utility questions to arrive at values of a QALY. Modelling resulted in
values of ÂŁ10,000-ÂŁ70,000 per QALY. Via survey research, most methods of aggregating the data resulted in values
of a QALY of ÂŁ18,000-ÂŁ40,000, although others resulted in implausibly high values. An additional survey, addressing
the issue of weighting QALYs, used two methods, one indicating that QALYs should not be weighted and the
other that greater weight could be given to QALYs gained by some groups.
Summary: Although we conducted only a feasibility study and a modelling exercise, neither present compelling
evidence for moving the NICE threshold up or down. Some preliminary evidence would indicate it could be
moved up for some types of QALY and down for others. While many members of the public appear to be open to
the possibility of using somewhat different QALY weights for different groups of beneficiaries, we do not yet have
any secure evidence base for introducing such a system
Towards More Accurate Molecular Dynamics Calculation of Thermal Conductivity. Case Study: GaN Bulk Crystals
Significant differences exist among literature for thermal conductivity of
various systems computed using molecular dynamics simulation. In some cases,
unphysical results, for example, negative thermal conductivity, have been
found. Using GaN as an example case and the direct non-equilibrium method,
extensive molecular dynamics simulations and Monte Carlo analysis of the
results have been carried out to quantify the uncertainty level of the
molecular dynamics methods and to identify the conditions that can yield
sufficiently accurate calculations of thermal conductivity. We found that the
errors of the calculations are mainly due to the statistical thermal
fluctuations. Extrapolating results to the limit of an infinite-size system
tend to magnify the errors and occasionally lead to unphysical results. The
error in bulk estimates can be reduced by performing longer time averages using
properly selected systems over a range of sample lengths. If the errors in the
conductivity estimates associated with each of the sample lengths are kept
below a certain threshold, the likelihood of obtaining unphysical bulk values
becomes insignificant. Using a Monte-Carlo approach developed here, we have
determined the probability distributions for the bulk thermal conductivities
obtained using the direct method. We also have observed a nonlinear effect that
can become a source of significant errors. For the extremely accurate results
presented here, we predict a [0001] GaN thermal conductivity of 185 at 300 K, 102 at 500 K, and 74
at 800 K. Using the insights obtained in the work, we have achieved a
corresponding error level (standard deviation) for the bulk (infinite sample
length) GaN thermal conductivity of less than 10 , 5 , and 15 at 300 K, 500 K, and 800 K respectively
Measuring the mean and scatter of the X-ray luminosity -- optical richness relation for maxBCG galaxy clusters
Determining the scaling relations between galaxy cluster observables requires
large samples of uniformly observed clusters. We measure the mean X-ray
luminosity--optical richness (L_X--N_200) relation for an approximately
volume-limited sample of more than 17,000 optically-selected clusters from the
maxBCG catalog spanning the redshift range 0.1<z<0.3. By stacking the X-ray
emission from many clusters using ROSAT All-Sky Survey data, we are able to
measure mean X-ray luminosities to ~10% (including systematic errors) for
clusters in nine independent optical richness bins. In addition, we are able to
crudely measure individual X-ray emission from ~800 of the richest clusters.
Assuming a log-normal form for the scatter in the L_X--N_200 relation, we
measure \sigma_\ln{L}=0.86+/-0.03 at fixed N_200. This scatter is large enough
to significantly bias the mean stacked relation. The corrected median relation
can be parameterized by L_X = (e^\alpha)(N_200/40)^\beta 10^42 h^-2 ergs/s,
where \alpha = 3.57+/-0.08 and \beta = 1.82+/-0.05. We find that X-ray selected
clusters are significantly brighter than optically-selected clusters at a given
optical richness. This selection bias explains the apparently X-ray
underluminous nature of optically-selected cluster catalogs.Comment: 21 pages, 12 figures, revised after referee's comments. ApJ accepte
The magnetic environment in the central region of nearby galaxies
The central regions of galaxies harbor some of the most extreme physical
phenomena, including dense stellar clusters, non-circular motions of molecular
clouds and strong and pervasive magnetic field structures. In particular, radio
observations have shown that the central few hundred parsecs of our Galaxy has
a striking magnetic field configuration. It is not yet clear whether these
magnetic structures are unique to our Milky Way or a common feature of all
similar galaxies. Therefore, we report on (a) a new radio polarimetric survey
of the central 200 pc of the Galaxy to better characterize the magnetic field
structure and (b) a search for large-scale and organized magnetized structure
in the nuclear regions of nearby galaxies using data from the Very Large Array
(VLA) archive. The high angular resolution of the VLA allows us to study the
central 1 kpc of the nearest galaxies to search for magnetized nuclear features
similar to what is detected in our own Galactic center. Such magnetic features
play a important role in the nuclear regions of galaxies in terms of gas
transport and the physical conditions of the interstellar medium in this
unusual region of galaxies.Comment: 8 pages; Proceedings for "The Universe under the Microscope" (AHAR
2008), held in Bad Honnef (Germany) in April 2008, to be published in Journal
of Physics: Conference Series by Institute of Physics Publishing, R.
Schoedel, A. Eckart, S. Pfalzner, and E. Ros (eds.
Trading people versus trading time: What is the difference?
BACKGROUND: Person trade-off (PTO) elicitations yield different values than standard utility measures, such as time trade-off (TTO) elicitations. Some people believe this difference arises because the PTO captures the importance of distributive principles other than maximizing treatment benefits. We conducted a qualitative study to determine whether people mention considerations related to distributive principles other than QALY-maximization more often in PTO elicitations than in TTO elicitations and whether this could account for the empirical differences. METHODS: 64 members of the general public were randomized to one of three different face-to-face interviews, thinking aloud as they responded to TTO and PTO elicitations. Participants responded to a TTO followed by a PTO elicitation within contexts that compared either: 1) two life-saving treatments; 2) two cure treatments; or 3) a life-saving treatment versus a cure treatment. RESULTS: When people were asked to choose between life-saving treatments, non-maximizing principles were more common with the PTO than the TTO task. Only 5% of participants considered non-maximizing principles as they responded to the TTO elicitation compared to 68% of participants who did so when responding to the PTO elicitation. Non-maximizing principles that emerged included importance of equality of life and a desire to avoid discrimination. However, these principles were less common in the other two contexts. Regardless of context, though, participants were significantly more likely to respond from a societal perspective with the PTO compared to the TTO elicitation. CONCLUSION: When lives are at stake, within the context of a PTO elicitation, people are more likely to consider non-maximizing principles, including the importance of equal access to a life-saving treatment, avoiding prejudice or discrimination, and in rare cases giving treatment priority based purely on the position of being worse-off
Salmonella Isolated from Animals and Feed Production in Sweden Between 1993 and 1997
This paper presents Salmonella data from animals, feedstuffs and feed mills in Sweden between 1993 and 1997. During that period, 555 isolates were recorded from animals, representing 87 serotypes. Of those, 30 serotypes were found in animals in Sweden for the first time. The majority of all isolates from animals were S. Typhimurium (n = 91), followed by S. Dublin (n = 82). There were 115 isolates from cattle, 21 from broilers, 56 from layers and 18 from swine. The majority of these isolates were from outbreaks, although some were isolated at the surveillance at slaughterhouses. The number of isolates from the feed industry was similar to that of the previous 5-year period. Most of those findings were from dust and scrapings from feed mills, in accordance with the HACCP programme in the feed control programme. It can be concluded that the occurrence of Salmonella in animals and in the feed production in Sweden remained favourable during 1993â97
The Distribution Of Chlorine And Iodine In Soil In The Vicinity Of Lead Mining And Smelting Operations, Bixby Area, S.E. Missouri, U.S.A.
Iodine and Cl are enriched in soils in the vicinity of the Magmont and Buick lead mines near Bixby, southeastern Missouri. The enrichments, up to 5.6 ppm I and 305 ppm Cl, are against regional background of 1.26 ppm I and 41 ppm Cl. The area of highest I and Cl is thought to reflect a zone of base metal sulphide mineralization occurring about 400 m below the surface. Iodine and Cl are also enriched in soils immediately adjacent to a tailings pond, hence these elements would appear to be leached from this source. A zone of enhanced I values (up to 2.65 ppm I) to the north of a lead smelter is superimposed on a much larger zone of lead enrichment (up to 12,000 ppm Pb) and is thought to represent I released from sulphide ores on smelting. © 1988
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