Gamma-ray line emission from Al-26 produced by Wolf-Rayet stars

The recent satellite observations of the 1.8 MeV line from the decay of Al-26 has given a new impetus to the study of the nucleosynthesis of Al-26. The production and ejection of Al-26 by massive mass-losing stars (Of and WR stars) is discussed in the light of recent stellar models. The longitude distribution of the Al-26 gamma ray line emission produced by the galactic collection of WR stars is derived based on various estimates of their radial distribution. This longitude profile provides: (1) a specific signature of massive stars on the background of other potential Al-26 sources, as novae, supernovae, certain red giants and possibly AGB stars; and (2) a possible tool to improve the data analysis of the HEAO 3 and SMM experiments

Intermediate mass stars: updated models

A new set of stellar models in the mass range 1.2 to 9 $M_{\odot}$ is presented. The adopted chemical compositions cover the typical galactic values, namely $0.0001 \le Z \le 0.02$ and $0.23 \le Y \le 0.28$. A comparison among the most recent compilations of similar stellar models is also discussed. The main conclusion is that the differencies among the various evolutionary results are still rather large. For example, we found that the H-burning evolutionary time may differ up to 20 %. An even larger disagreement is found for the He-burning phase (up to 40-50 %). Since the connection between the various input physics and the numerical algorithms could amplify or counterbalance the effect of a single ingredient on the resulting stellar model, the origin of this discrepancies is not evident. However most of these discrepancies, which are clearly found in the evolutionary tracks, are reduced on the isochrones. By means of our updated models we show that the ages inferred by the theory of stellar evolution is in excellent agreement with those obtained by using other independent methods applied to the nearby Open Clusters. Finally, the theoretical initial/final mass relation is revised.Comment: 35 pages, 24 figures, 4 tables, accepted for publication in the Astrophisycal Journa

Mass-luminosity relation and pulsational properties of Wolf-Rayet stars

Evolution of Population I stars with initial masses from 70M_\odot to 130M_\odot is considered under various assumptions on the mass loss rate \dot M. The mass-luminosity relation of W-R stars is shown to be most sensitive to the mass loss rate during the helium burning phase \dot M_{3\alpha}. Together with the mass-luminosity relation obtained for all evolutionary sequences several more exact relations are determined for the constant ratio f_{3\alpha}=\dot M/\dot M_{3\alpha} with 0.5 \le f_{3\alpha} \le 3. Evolutionary models of W-R stars were used as initial conditions in hydrodynamic computations of radial nonlinear stellar oscillations. The oscillation amplitude is larger in W-R stars with smaller initial mass or with lower mass loss rate due to higher surface abundances of carbon and oxygen. In the evolving W-R star the oscillation amplitude decreases with decreasing stellar mass M and for M < 10M_\odot the sufficiently small nonlinear effects allow us to calculate the integral of the mechanical work W done over the pulsation cycle in each mass zone of the hydrodynamical model. The only positive maximum on the radial dependence of W is in the layers with temperature of T\sim 2e5K where oscillations are excited by the iron Z--bump kappa-mechanism. Radial oscillations of W-R stars with mass of M > 10M_\odot are shown to be also excited by the kappa-mechanism but the instability driving zone is at the bottom of the envelope and pulsation motions exist in the form of nonlinear running waves propagating outward from the inner layers of the envelope.Comment: 15 pages, 10 figures, submitted to Astronomy Letter

Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression

The telomerase reverse transcriptase (TERT) gene is responsible for telomere maintenance in germline and stem cells, and is re-expressed in 90% of human cancers. CpG methylation in the TERT promoter (TERTp) was correlated with TERT mRNA expression. Furthermore, two hotspot mutations in TERTp, dubbed C228T and C250T, have been revealed to facilitate binding of transcription factor ETS/TCF and subsequent TERT expression. This study aimed to elucidate the combined contribution of epigenetic (promoter methylation and chromatin accessibility) and genetic (promoter mutations) mechanisms in regulating TERT gene expression in healthy skin samples and in melanoma cell lines (n = 61). We unexpectedly observed that the methylation of TERTp was as high in a subset of healthy skin cells, mainly keratinocytes, as in cutaneous melanoma cell lines. In spite of the high promoter methylation fraction in wild-type (WT) samples, TERT mRNA was only expressed in the melanoma cell lines with either high methylation or intermediate methylation in combination with TERT mutations. TERTp methylation was positively correlated with chromatin accessibility and TERT mRNA expression in 8 melanoma cell lines. Cooperation between epigenetic and genetic mechanisms were best observed in heterozygous mutant cell lines as chromosome accessibility preferentially concerned the mutant allele. Combined, these results suggest a complex model in which TERT expression requires either a widely open chromatin state in TERTp-WT samples due to high methylation throughout the promoter or a combination of moderate methylation fraction/chromatin accessibility in the presence of the C228T or C250T mutations.Dermatology-oncolog

Vacuum Chamber Design of NSLS-II Storage Ring

National Synchrotron Light Source II (NSLS II) will be a 3-GeV, 792-meter circumference, 3rd generation synchrotron radiation facility, with ultra low emittance and extremely high brightness. the storage ring has 30 Double-Bend-Achromatic (DBA) cells. in each cell, there are five magnets and chamber girders, and one straight section for insertion devices or Radio Frequency (RF) cavities or injection. Most vacuum chambers are made from extruded aluminum with two different cross sections: one fitted in the dipole magnets, and the other surrounded by multipole magnets. They discuss the layout of the DBA cells, the detailed design of the cell's vacuum chambers, the mounting of the Beam-Position-Monitor (BPM) buttons, discrete absorbers, lumped pumps and the distributed Non-Evaporable Getter (NEG) strips, and describe the fabrication and testing of these prototype cell chambers. The account also details the development of the chamber bakeout process, the NEG stri's supports, and the RF shielded bellows

Family conflict, chaos, and negative life events predict cortisol activity in low‐income children

Childhood poverty is hypothesized to increase risk for mental and physical health problems at least in part through dysregulation of the hypothalamic‐pituitary‐adrenal axis. However, less is known about the specific psychosocial stressors associated with cortisol reactivity and regulation for children living in poverty. The current study investigates negative life events, household chaos, and family conflict in preschool and middle childhood as potential predictors of cortisol regulation in low‐income 7–10 year olds (N = 242; M age = 7.9 years). Participants were assessed in preschool and participated in a follow‐up assessment in middle childhood, during which diurnal free cortisol and free cortisol reactivity to the Trier Social Stress Test for Children (TSST‐C) were assessed. Household chaos during preschool predicted a more blunted diurnal cortisol slope in middle childhood. Greater negative life events during preschool and greater concurrent family conflict were associated with increased free cortisol reactivity in middle childhood.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144279/1/dev21602_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144279/2/dev21602.pd

Molecular techniques for pathogen identification and fungus detection in the environment

Many species of fungi can cause disease in plants, animals and humans. Accurate and robust detection and quantification of fungi is essential for diagnosis, modeling and surveillance. Also direct detection of fungi enables a deeper understanding of natural microbial communities, particularly as a great many fungi are difficult or impossible to cultivate. In the last decade, effective amplification platforms, probe development and various quantitative PCR technologies have revolutionized research on fungal detection and identification. Examples of the latest technology in fungal detection and differentiation are discussed here

Malignant inflammation in cutaneous T-cell lymphoma: a hostile takeover

Cutaneous T-cell lymphomas (CTCL) are characterized by the presence of chronically inflamed skin lesions containing malignant T cells. Early disease presents as limited skin patches or plaques and exhibits an indolent behavior. For many patients, the disease never progresses beyond this stage, but in approximately one third of patients, the disease becomes progressive, and the skin lesions start to expand and evolve. Eventually, overt tumors develop and the malignant T cells may disseminate to the blood, lymph nodes, bone marrow, and visceral organs, often with a fatal outcome. The transition from early indolent to progressive and advanced disease is accompanied by a significant shift in the nature of the tumor-associated inflammation. This shift does not appear to be an epiphenomenon but rather a critical step in disease progression. Emerging evidence supports that the malignant T cells take control of the inflammatory environment, suppressing cellular immunity and anti-tumor responses while promoting a chronic inflammatory milieu that fuels their own expansion. Here, we review the inflammatory changes associated with disease progression in CTCL and point to their wider relevance in other cancer contexts. We further define the term "malignant inflammation" as a pro-tumorigenic inflammatory environment orchestrated by the tumor cells and discuss some of the mechanisms driving the development of malignant inflammation in CTCL

Cytomegalovirus infection in pediatric rheumatic diseases: a review

Human cytomegalovirus (HCMV) is familiar to pediatric rheumatologists mainly as a cause of opportunistic disease in pharmacologically immune suppressed patients. However, HCMV also has a variety of immuno-modulatory effects, through which it may influence the course of rheumatic conditions. In this article we discuss the interplay between HCMV and the immune system, and review the clinical manifestations, diagnosis, and treatment of HCMV infection in children with rheumatic disease