Tests and foreseen developments of fibered-OSLD gamma heating measurements in low-power reactors

International audienceIn this paper are presented test measurements of a fibered-OSLD system performed during a dedicated experimental phase in EOLE zero-power reactor. The measurement setup consists of an OSLD crystal connected onto the extremity of an optical fiber and a laser stimulation system, manufactured by the CEA/LIST in Saclay. The OSL sensor is remotely stimulated via an optical fiber using a diode-pumped solid-state laser. The OSL light is collected and guided back along the same fiber to a photomultiplier tube. Results obtained using this system are compared to usual gamma heating measurement protocol using OSLD pellets. The presence of induced radio-luminescence in the OSLD during the irradiation was also observed and could be used to monitor the gamma flux.The feasibility of remote measurements is achieved, whereas further developments could be conducted to improve this technique since the readout procedure still requires to withdraw the OSLD off the gamma flux (hence from the core) on account of the dose rate (around a few Gy.h-1), and the readout time remains quite long for on-line applications. Several improvements are foreseen, and will be tested in the forthcoming years

Analytical investigation and experimental application of the source modulation technique to measure ρ/βeff\rho/\beta_{eff}

In recent years great interest has been displayed, worldwide, for Accelerator Driven Sub critical reactors (ADS) to incinerate the minor actinides generated by the existing energy producing reactors. In sub critical systems, the effective neutron multiplication factor is lower than 1.0 and the neutrons otherwise required to maintain the chain reaction, can be put to other uses, in particular, the destruction of nuclear wastes such as minor actinides (MA). One of the major advantages of such ADS systems is that it can be operated with very high M.A content without jeopardizing the overall safety due to a small effective delayed neutron fraction, a small Doppler temperature coefficient and possibly also a large void coefficient depending on the chosen coolant. This enhanced safety however prerequisites at all time a sufficient subcriticality margin. Reliable reactivity monitoring techniques are hence required to achieve this goal. The MUSE-4 program is a series of low power experiments carried out at the CEA-Cadarache MASURCA facility to investigate the various methods leading to the measurement of the reactivity level and associated kinetic parameters such as the effective delayed neutron fraction. The aim of this paper is to present the results obtained with a method which directly gives the ratio, for a sub critical assembly, between the reactivity ρ and the effective delayed neutron fraction βeff. By combining these results to those obtained with the kp-method for the prompt neutron multiplication coefficient, we have access to the parameters which govern the prompt and the slow kinetics of a sub critical assembly. These parameters can be obtained without reference to any calibration measurement in critical configuration. It opens the way to the control of larger sub critical demonstrators which are operating with fuels which cannot be used in critical reactor, and, thanks to sub criticality, which are characterized by a deterministic safety

Opto-PCB: Three demonstrators for optical interconnections

We report on a research project targeting optical waveguide integrated PCBs conducted within the European FP6 Network of Excellence on Micro-Optics NEMO. For three identified feature requests we have built three specific demonstrators respectively addressing the integration of active components, the fabrication of peripheral fibre ribbons and the integration of multiple layers of waveguides on the board

Synthesis and Investigation of a Radioiodinated F3 Peptide Analog as a SPECT Tumor Imaging Radioligand

A radioiodinated derivative of the tumor-homing F3 peptide, (N-(2-{3-[125I]Iodobenzoyl}aminoethyl)maleimide-F3Cys peptide, [125I]IBMF3 was developed for investigation as a SPECT tumor imaging radioligand. For this purpose, we custom synthesized a modified F3 peptide analog (F3Cys) incorporating a C-terminal cysteine residue for site-specific attachment of a radioiodinated maleimide conjugating group. Initial proof-of-concept Fluorescence studies conducted with AlexaFluor 532 C5 maleimide-labeled F3Cys showed distinct membrane and nuclear localization of F3Cys in MDA-MB-435 cells. Additionally, F3Cys conjugated with NIR fluorochrome AlexaFluor 647 C2 maleimide demonstrated high tumor specific uptake in melanoma cancer MDA-MB-435 and lung cancer A549 xenografts in nude mice whereas a similarly labeled control peptide did not show any tumor uptake. These results were also confirmed by ex vivo tissue analysis. No-carrier-added [125I]IBMF3 was synthesized by a radioiododestannylation approach in 73% overall radiochemical yield. In vitro cell uptake studies conducted with [125I]IBMF3 displayed a 5-fold increase in its cell uptake at 4 h when compared to controls. SPECT imaging studies with [125I]IBMF3 in tumor bearing nude mice showed clear visualization of MDA-MB-435 xenografts on systemic administration. These studies demonstrate a potential utility of F3 peptide-based radioligands for tumor imaging with PET or SPECT techniques