Smart Cities : is It Just a Fad?

This editorial frames the contents of this special issue within the broad context of the smart city literature. In particular, the editorial first argues for the novelty of the smart city concept with respect to previous planning notions. The smart city literature has provided much insight into present-day urban management issues. In this sense, this special issues presents new insights into the following topics: (i) The smart city literature is characterized by remarkable heterogeneity in terms of geographical and disciplinary approaches; (ii) Relevant attention is being paid to the impact of smart city policies; (iii) New findings are presented for the relevance of benchmarking exercises and a first quantitative impact measurement is discussed; (iv) Beyond the new results presented in the Special Issue, ample space is dedicated to the discussion of future challenges for this literature, for both academics and policymaker

Public enterprises, policy adoption and planning: three welfare propositions

Public enterprises are production units of goods or services under government control. In spite of wide privatizations in the last two decades, public provision in this form can be observed in many countries and sectors, particularly in education, health, transport, energy and environment. This paper uses social Cost Benefit Analysis (CBA) theory to explore the rationale for public enterprises. Three welfare propositions arise from CBA theory in a general equilibrium setting: (1) Under symmetric information and benevolent government, public provision is socially beneficial if: (a) there is a well defined production plan for some goods; (b) optimal policy and socially desirable projects are selected in such a way as to pass a social cost-benefit test at shadow prices; (c) production can never be shut down for some socially desirable goods and optimal procurement is equivalent to public production. (2) Under not (fully) benevolent government, and asymmetric information: (a) sub-optimal policy adoption leads to inconsistency in project selection; (b) the allocation of property rights will also be distorted, as privatization or government ownership are signals fixed by the government; (c) public provision and public procurement will be no more equivalent, because fo differences in information costs. (3) If the social planner is not fully benevolent, but cannot profit from policy design: (a) shadow prices are still sufficient statistics for the evaluating changes of the public plan; (b) public enterprises will be welfare superior to privately-owned enterprises (POEs) when the rents of the planner related to public ownership are less than the rents of the private providers under procurement, and shadow prices must be used to compare the outcomes. The message of the paper points to the overall quality of institutions as a pre-condition for socially desirable public enterprises as this environment provides policy-makers with the correct incentives to design and implement meaningful policies even when public administrators adopt sub-optimal plans. Hence, the building of a sound quality of institutions should be primarily focused on those mechanisms that select policies. Institutions should constrain self-interested policy-makers from disrupting the welfare signals for policy adoption as well as for project appraisal

Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression

Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme involved in the protection of low-density lipoprotein and HDLs against lipid peroxidation. Several studies documented the capacity of polyphenols to stimulate PON1 transcription activation. The objective of the present review is to provide the main evidence about the role and the potential mechanism of action of polyphenols and polyphenol-rich foods in the modulation of PON1 gene expression and activity. A total of 76 in vitro and in vivo studies were included in the review. Overall, while evidence obtained in vitro is limited to quercetin and resveratrol, those deriving from animal models seem more convincing for a wide range of polyphenols but only at pharmacological doses. Evidence from human studies is promising but deserves more substantiation about the role of polyphenol-rich foods in the regulation of PON1 activity and expression. Research focused on the understanding of the structure\u2013activity relationship of polyphenols with PON1 and on the mechanisms at the base of PON1 modulation is warranted. Well-designed human intervention studies are encouraged to corroborate the findings of polyphenols also at physiological doses

Berries and oxidative stress markers: an overview of human intervention studies

Berries are an excellent source of bioactive compounds such as vitamins, minerals but above all polyphenols with anthocyanins as the most representative compounds. Several in vitro and in vivo studies documented the beneficial effects of berries and their bioactives in the modulation of numerous cell functions related to oxidative stress and/or antioxidant protection. The following review summarizes published results about the role of berries (either fresh, juice, freeze-dried or dehydrated) on total plasma and serum antioxidant status and on the modulation of biomarkers of oxidative stress in acute and chronic human intervention trials. The biomarkers considered include DNA, protein and lipid oxidation, and endogenous antioxidant enzymes. Though limited, there is indication that the consumption of berries may reduce oxidative stress by modulating protein and lipid oxidation, and by improving total antioxidant status. In particular, these effects are more evident following chronic dietary interventions with respect to postprandial studies. Benefits are observed in healthy subjects as well as in those with cardiovascular risk factors or other diseases. On the contrary, data regarding the effect of berries on DNA damage and endogenous antioxidant enzyme activities are still scarce and inconclusive. In conclusion, much remains to be elucidated before a comprehensive understanding of the effects of berries on the modulation of oxidative stress markers is achieved. Robust clinical evidence supporting the role of berries in counteracting oxidative stress in humans is encouraged

Anthocyanins and metabolites resolve TNF-α-mediated production of E-selectin and adhesion of monocytes to endothelial cells

This study investigated the capacity of an anthocyanin-rich fraction (ACN-RF) from blueberry, single anthocyanins (cyanidin, delphinidin and malvidin-3-glucoside; Cy, Dp and Mv-3-glc) and related metabolites (protocatechuic, gallic and syringic acid; PrA, GA and SA) to resolve an inflammation-driven adhesion of monocytes (THP-1) on endothelial cell (HUVECs) and secretion of cell adhesion molecules E-selectin and vascular cell adhesion molecule 1 (VCAM-1). The adhesion of THP-1 to HUVECs was induced by tumour necrosis factor \u3b1 (TNF-\u3b1, 100\u202fng\u202fmL-1). Subsequently, ACN-RF, single ACNs and metabolites (from 0.01 to 10\u202f\u3bcg\u202fmL-1) were incubated for 24\u202fh. The adhesion was measured in a fluorescence spectrophotometer. E-selectin and VCAM-1 were quantified by ELISA. No toxicological effects were observed for the compounds and the doses tested. ACN-RF and Mv-3-glc reducedTHP-1 adhesion at all the concentrations with the maximum effect at 10 \u3bcg/ml (-60.2% for ACNs and-33.9% for Mv-3-glc). Cy-3-glc decreased the adhesion by about 41.8% at 10\u202f\u3bcg\u202fmL-1, while PrA and GA reduced the adhesion of THP-1 to HUVECs both at 1 and at 10\u202f\u3bcg\u202fmL-1 (-29.5% and -44.3% for PrA, respectively, and -18.0%and -59.3% for GA, respectively). At the same concentrations a significant reduction of E-selectin, but notVCAM-1 levels, was documented. No effect was observed following Dp-3-glc and SA supplementation. Overall, ACNs and metabolites seem to resolve, in a dose-dependent manner, the inflammation-driven adhesion of THP-1 to HUVECs by decreasing E-selectin concentrations. Interestingly, Mv-3-glc was active at physiologically relevant concentrations

Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency : a randomized controlled trial

Background & Aims: Vegetarians and vegans are more vulnerable to vitamin B12 deficiency with severe risks of megaloblastic anemia, cognitive decline, neuropathy, and depression. An easy and simple method of supplementation consists of taking one weekly dosage of 2000 \ub5g. However, single large oral doses of vitamin B12 are poorly absorbed. The present research evaluates the ability of two different sublingual dosages of vitamin B12 (350 \ub5g/week vs. 2000 \ub5g/week) in improving cyanocobalamin (vitamin B12) nutritional status in vegans and vegetarians with a marginal deficiency. Methods: A 12-week randomized, double-blind, controlled, parallel intervention trial was performed. Forty subjects with marginal vitamin B12 deficiency were enrolled and randomly divided into two groups: test group Ld (low dose, 350 \ub5g/week) and control group Hd (high dose, 2000 \ub5g/week) vitamin B12 supplementation. Blood samples were collected at baseline and after 15, 30, 60, and 90 days from the intervention for the determination of vitamin B12, related metabolic markers, and blood cell counts. Results: Two-way analysis of variance showed a significant effect of time (P < 0.0001) and of time x treatment interaction (P = 0.012) on serum concentration of vitamin B12. In particular, 90 days of supplementation increased the levels of cyanocobalamin (+81.8% in the Ld group and +144.0% in the Hd group) compared to baseline. A significant increase was observed for the levels of holotranscobalamin (+64.5% in the Ld group and +165.2% in the Hd group), while a decrease occurred for the levels of methylmalonic acid (-72.3% in the Ld group and -69.4% in the Hd group), homocysteine (-56.8% in the Ld group and -53.6% in the Hd group), and folate (-22.8% in the Ld group and -17.7% in the Hd group) compared to baseline (time effect, P < 0.0001). No difference was observed between groups (Ld vs. Hd). No effect was detected for the other variables under study. Conclusions: In our experimental conditions, both supplements were able to restore adequate serum concentrations of vitamin B12 and to improve the levels of related metabolic blood markers in subjects with a marginal deficiency. The results support the use of a sublingual dosage of 50 \ub5g/day (350 \ub5g/week) of cobalamin, instead of 2000 \ub5g/week (provided as a single dose), to reach a state of nutritional adequacy of vitamin B12 in this target population

Intra and inter-day repeatability of peripheral arterial function: suitability and potential limitations

The present study aimed to investigate the inter- and intraday repeatability of reactive hyperemia index (RHI) measured by Endo-PAT in healthy volunteers. Interday RHI repeatability was tested in two consecutive days in a group of thirty-one male subjects. Intraday repeatability was investigated at baseline and after 2 and 4 h in a group of sixteen volunteers. Data were evaluated by analysis of variance. Bland-Altman plot, coefficient of variation (CV), coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) were measured. While interday RHI repeatability was found to be reliable (CV: 6.0%; CR: 0.51; ICC: 0.77), multiple evaluations within the same day significantly (p<0.001) affected RHI (repeatability of the measurement - CV: 18.8%; CR: 1.26; ICC: 0.48). In particular, a significant increase in RHI occurred at 4 h compared to 2 h (+16.8%; p<0.05) and to baseline (+30.1%; p<0.05). In conclusion, RHI showed good interday but poor intraday repeatability. Multiple evaluations increased RHI especially in subjects with endothelial dysfunction who improved or reversed their impairment. These results show the potential limitations of multiple Endo-PAT measurements within the same day and the importance of standardizing the protocols before RHI evaluations

Effect of fiber and protein-enriched pasta formulations on satiety-related sensations and afternoon snacking in Italian healthy female subjects

The objective of the study was to investigate the effect of consuming different fiber and protein-enriched pasta formulations on satiety response and on mid-afternoon energy intake. Twenty Italian young healthy female subjects participated to a randomized repeated measure study design developed to evaluate the effect on satiety and energy intake of five different pasta formulations, i.e. high fiber, high fiber and high protein, high protein from soy, high protein from egg white, and standard commercial pasta consumed at lunch. The formulations together with a portion of fruit were consumed on five different occasions followed by an ad libitum snack meal proposed 2 h later. Before, immediately after the lunch consumption, and every 30 min until snack time, satiety sensations were assessed by visual analogue scales. In addition, mid-afternoon energy and macronutrient intake consumed with the snacks were calculated. Compared to the control pasta, all the formulations significantly affected satiety-related sensations. Palatability-related attributes of pasta were positively correlated to snack energy intake, whereas fullness sensation was negatively correlated. Among the formulations tested only the fiber and protein-enriched pasta significantly reduced energy intake following the ad libitum snack consumption (p < 0.05). Overall, these findings suggest that pasta enriched with a combination of fiber and protein, might be effective in the modulation of appetite sensations, thus suggesting a new concept-pasta formulation for the modulation of eating behavior. These results are interesting considering that pasta is a staple food in different target groups of the population