Quantum disordered phase in a doped antiferromagnet

A quantitative description of the transition to a quantum disordered phase in a doped antiferromagnet is obtained with a U(1) gauge-theory, where the gap in the spin-wave spectrum determines the strength of the gauge-fields. They mediate an attractive long-range interaction whose possible bound-states correspond to charge-spin separation and pairing.Comment: 11 pages, LaTex, chris-preprint-1994-

Finite size effects and scaling in lattice CP(N-1)

We present model predictions for the spectrum of $CP^{N-1}$ in a periodic box and use them to interpret the strong finite size effects observed in lattice simulations at medium values of $N$. The asymptotic scaling behaviour of alternative lattice actions is discussed along with some aspects of multigrid algorithm efficiency.Comment: 6 pages of text plus 2 pages of figures, Liverpool Preprint LTH28

On the Low-Energy Effective Action of N=2 Supersymmetric Yang-Mills Theory

We investigate the perturbative part of Seiberg's low-energy effective action of N=2 supersymmetric Yang-Mills theory in Wess-Zumino gauge in the conventional effective field theory technique. Using the method of constant field approximation and restricting the effective action with at most two derivatives and not more than four-fermion couplings, we show some features of the low-energy effective action given by Seiberg based on $U(1)_R$ anomaly and non-perturbative $\beta$-function arguments.Comment: 27 pages, RevTex, no figure

Comments on Supersymmetric Vector and Matrix Models

Some results in random matrices are generalized to supermatrices, in particular supermatrix integration is reduced to an integration over the eigenvalues and the resulting volume element is shown to be equivalent to a one dimensional Coulomb gas of both positive and negative charges.It is shown that,for polynomial potentials, after removing the instability due to the annihilation of opposite charges, supermatrix models are indistinguishable from ordinary matrix models, in agreement with a recent result by Alvarez-Gaume and Manes. It is pointed out however that this may not be true for more general potentials such as for instance the supersymmetric generalization of the Penner model.Comment: 6 page

CP^{N-1} models and the Quantized 2D Black Holes

We have examined the coupled system of the dilaton gravity and the $CP^{N-1}$ theory known as a model of the confinement of massive scalar quarks. After the quantization of the system, we could see the quantum effect of the gravitation on the coupling constant of $CP^{N-1}$ model and how the coupling constant of dynamically induced gauge field changes near the black hole configuration.Comment: 12 pages, Late

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, telomere dysfunction and premature entry into cellular senescence. Recently, we reported that telomere dysfunction induces the transcription of telomeric non-coding RNAs (tncRNAs) which control the DNA damage response (DDR) at dysfunctional telomeres. Here we show that progerin-induced telomere dysfunction induces the transcription of tncRNAs. Their functional inhibition by sequence-specific telomeric antisense oligonucleotides (tASOs) prevents full DDR activation and premature cellular senescence in various HGPS cell systems, including HGPS patient fibroblasts. We also show in vivo that tASO treatment significantly enhances skin homeostasis and lifespan in a transgenic HGPS mouse model. In summary, our results demonstrate an important role for telomeric DDR activation in HGPS progeroid detrimental phenotypes in vitro and in vivo

Implications of the Partial Ring Design for a Clinical SPECT Insert

The INSERT system is a stationary SPECT insert designed for clinical SPECT/MRI. The system has been evaluated as a standalone SPECT scanner and here the image reconstruction is evaluated to determine the implications of its design. A two-step image acquisition can be implemented to overcome the limitations of the partial ring design. The image quality and activity linearity are evaluated through a set of point sources and vials of varying activity concentration. The evaluation highlighted areas where image reconstruction and data processing needed to improve before proceeding to simultaneous SPECT/MRI acquisitions. We have shown that the proposed dual acquisition method can produce improved image quality through the use of modified data acquisition and reconstruction protocols